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Article: A prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients

TitleA prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients
Authors
KeywordsDosimetric Changes
Head-And-Neck Cancer
Intensity-Modulated Radiotherapy
Nasopharyngeal Carcinoma
Volumetric Changes
Issue Date2012
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/radonc
Citation
Radiotherapy And Oncology, 2012, v. 104 n. 3, p. 317-323 How to Cite?
AbstractBackground and purpose: Significant tumor shrinkage and weight loss may occur during Intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). This study aims to evaluate the dosimetric effect of volumetric changes on target volumes and organs at risk (OARs) during IMRT, using reassessment of computed tomography (CT) and magnetic resonance imaging (MRI). Material and methods: Nineteen loco-regionally advanced NPC patients treated with IMRT were recruited prospectively. Repeat planning CT and MRI were acquired at 30 and 50 Gy intervals. Recontouring of target volumes and OARs was based on the fused CT-MRI images. Hybrid plans with recontouring were generated. The assessment of volumetric and dosimetric changes was performed by comparing the hybrid plans with the original plan. Results: There was volume reduction of target volumes and parotid glands over the course of IMRT. Relative to the original plan, the hybrid plans demonstrated significantly higher dose to most of target volumes with greater dose inhomogeneity, higher maximum doses to the spinal cord and brainstem, and higher median doses to the parotid glands. Conclusions: Replanning with repeat CT and MRI scans at 30 Gy is essential to keep a satisfactory dose to the target volumes and avoid overdosing the OARs. © 2012 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150856
ISSN
2015 Impact Factor: 4.817
2015 SCImago Journal Rankings: 2.654
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, HCYen_US
dc.contributor.authorWu, VWCen_US
dc.contributor.authorNgan, RKCen_US
dc.contributor.authorTang, KWen_US
dc.contributor.authorChan, CCLen_US
dc.contributor.authorWong, KHen_US
dc.contributor.authorAu, SKen_US
dc.contributor.authorKwong, DLWen_US
dc.date.accessioned2012-06-26T06:12:42Z-
dc.date.available2012-06-26T06:12:42Z-
dc.date.issued2012en_US
dc.identifier.citationRadiotherapy And Oncology, 2012, v. 104 n. 3, p. 317-323en_US
dc.identifier.issn0167-8140en_US
dc.identifier.urihttp://hdl.handle.net/10722/150856-
dc.description.abstractBackground and purpose: Significant tumor shrinkage and weight loss may occur during Intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). This study aims to evaluate the dosimetric effect of volumetric changes on target volumes and organs at risk (OARs) during IMRT, using reassessment of computed tomography (CT) and magnetic resonance imaging (MRI). Material and methods: Nineteen loco-regionally advanced NPC patients treated with IMRT were recruited prospectively. Repeat planning CT and MRI were acquired at 30 and 50 Gy intervals. Recontouring of target volumes and OARs was based on the fused CT-MRI images. Hybrid plans with recontouring were generated. The assessment of volumetric and dosimetric changes was performed by comparing the hybrid plans with the original plan. Results: There was volume reduction of target volumes and parotid glands over the course of IMRT. Relative to the original plan, the hybrid plans demonstrated significantly higher dose to most of target volumes with greater dose inhomogeneity, higher maximum doses to the spinal cord and brainstem, and higher median doses to the parotid glands. Conclusions: Replanning with repeat CT and MRI scans at 30 Gy is essential to keep a satisfactory dose to the target volumes and avoid overdosing the OARs. © 2012 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/radoncen_US
dc.relation.ispartofRadiotherapy and Oncologyen_US
dc.subjectDosimetric Changesen_US
dc.subjectHead-And-Neck Canceren_US
dc.subjectIntensity-Modulated Radiotherapyen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.subjectVolumetric Changesen_US
dc.titleA prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patientsen_US
dc.typeArticleen_US
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_US
dc.identifier.emailNgan, KC: rkcngan@hkucc.hku.hk-
dc.identifier.emailAu, SK: ausk@hkucc.hku.hk-
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.radonc.2012.03.013en_US
dc.identifier.pmid22551564-
dc.identifier.scopuseid_2-s2.0-84867092309en_US
dc.identifier.hkuros210075-
dc.identifier.eissn1879-0887-
dc.identifier.isiWOS:000310405000009-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridCheng, HCY=36518476700en_US
dc.identifier.scopusauthoridWu, VWC=7006045803en_US
dc.identifier.scopusauthoridNgan, RKC=6701397734en_US
dc.identifier.scopusauthoridTang, KW=55207153200en_US
dc.identifier.scopusauthoridChan, CCL=55206077700en_US
dc.identifier.scopusauthoridWong, KH=35097874900en_US
dc.identifier.scopusauthoridAu, SK=7005457822en_US
dc.identifier.scopusauthoridKwong, DLW=15744231600en_US
dc.identifier.citeulike10646709-

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