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Article: Deciphering the molecular genetic basis of NPC through functional approaches

TitleDeciphering the molecular genetic basis of NPC through functional approaches
Authors
KeywordsMicrocell hybrid
Microcell-mediated chromosome transfer
Nasopharyngeal carcinoma
Tumor segregant
Tumor suppressor gene
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
Citation
Seminars In Cancer Biology, 2012, v. 22 n. 2, p. 87-95 How to Cite?
AbstractThe identification of cancer genes in sporadic cancers has been recognized as a major challenge in the field. It is clear that deletion mapping, genomic sequencing, comparative genomic hybridization, or global gene expression profiling alone would not have easily identified candidate tumor suppressor genes (TSGs) from the huge array of lost regions or genes observed in nasopharyngeal carcinoma (NPC). In addition, the epigenetically silenced genes would not have been recognized by the mapping of deleted regions. In this review, we describe how functional approaches using monochromosome transfer may be used to circumvent the above problems and identify TSGs in NPC. A few examples of selected NPC TSGs and their functional roles are reviewed. They regulate a variety of gene functions including cell growth and proliferation, adhesion, migration, invasion, epithelial-mesenchymal transition, metastasis, and angiogenesis. These studies show the advantages of using functional approaches for identification of TSGs. © 2011 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/150852
ISSN
2015 Impact Factor: 9.955
2015 SCImago Journal Rankings: 6.320
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 661708M
HKU 661507M
HKUST 6611204M
Central Allocation GrantCA03/04.SC01
University Grants CouncilAoE/M-06/08
Funding Information:

Hong Kong Research Grants Council General Research Grants HKU 661708M, HKU 661507M, HKUST 6611204M and Central Allocation Grant CA03/04.SC01 and University Grants Council Area of Excellence Grant AoE/M-06/08 to M.L.L.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLung, HLen_HK
dc.contributor.authorCheung, AKLen_HK
dc.contributor.authorKo, JMYen_HK
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorStanbridge, EJen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2012-06-26T06:12:33Z-
dc.date.available2012-06-26T06:12:33Z-
dc.date.issued2012en_HK
dc.identifier.citationSeminars In Cancer Biology, 2012, v. 22 n. 2, p. 87-95en_HK
dc.identifier.issn1044-579Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/150852-
dc.description.abstractThe identification of cancer genes in sporadic cancers has been recognized as a major challenge in the field. It is clear that deletion mapping, genomic sequencing, comparative genomic hybridization, or global gene expression profiling alone would not have easily identified candidate tumor suppressor genes (TSGs) from the huge array of lost regions or genes observed in nasopharyngeal carcinoma (NPC). In addition, the epigenetically silenced genes would not have been recognized by the mapping of deleted regions. In this review, we describe how functional approaches using monochromosome transfer may be used to circumvent the above problems and identify TSGs in NPC. A few examples of selected NPC TSGs and their functional roles are reviewed. They regulate a variety of gene functions including cell growth and proliferation, adhesion, migration, invasion, epithelial-mesenchymal transition, metastasis, and angiogenesis. These studies show the advantages of using functional approaches for identification of TSGs. © 2011 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcanceren_HK
dc.relation.ispartofSeminars in Cancer Biologyen_HK
dc.subjectMicrocell hybriden_HK
dc.subjectMicrocell-mediated chromosome transferen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectTumor segreganten_HK
dc.subjectTumor suppressor geneen_HK
dc.titleDeciphering the molecular genetic basis of NPC through functional approachesen_HK
dc.typeArticleen_HK
dc.identifier.emailLung, HL: hllung2@hku.hken_HK
dc.identifier.emailCheung, AKL: arthurhk@hku.hken_HK
dc.identifier.emailCheng, Y: yuecheng@hku.hken_HK
dc.identifier.emailLung, ML: mlilung@hku.hken_HK
dc.identifier.authorityLung, HL=rp00299en_HK
dc.identifier.authorityCheung, AKL=rp01769en_HK
dc.identifier.authorityCheng, Y=rp01320en_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/j.semcancer.2011.11.002en_HK
dc.identifier.pmid22154888-
dc.identifier.scopuseid_2-s2.0-84857786329en_HK
dc.identifier.hkuros199895-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857786329&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue2en_HK
dc.identifier.spage87en_HK
dc.identifier.epage95en_HK
dc.identifier.isiWOS:000302450100003-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectCentre for Nasopharyngeal Carcinoma Research-
dc.relation.projectMolecular and functional studies of the role of chromosome 14q candidate genes, CRIP2 and MIPOL1, in nasopharyngeal and esophageal carcinomas-
dc.relation.projectMolecular and Functional Investigation of the Role of Two Metalloproteinases in Nasopharyngeal Carcinoma Tumorigenesis-
dc.identifier.scopusauthoridLung, HL=6603819904en_HK
dc.identifier.scopusauthoridCheung, AKL=8967932600en_HK
dc.identifier.scopusauthoridKo, JMY=35725559400en_HK
dc.identifier.scopusauthoridCheng, Y=36131038300en_HK
dc.identifier.scopusauthoridStanbridge, EJ=7103249410en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.identifier.citeulike10259371-

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