Article: Deciphering the molecular genetic basis of NPC through functional approaches

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TitleDeciphering the molecular genetic basis of NPC through functional approaches
AuthorsLung, HL1
Cheung, AKL1
Ko, JMY1
Cheng, Y1
Stanbridge, EJ2
Lung, ML1
KeywordsMicrocell Hybrid
Microcell-Mediated Chromosome Transfer
Nasopharyngeal Carcinoma
Tumor Segregant
Tumor Suppressor Gene
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
CitationSeminars in Cancer Biology, 2012, v. 22 n. 2, p. 87-95 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.semcancer.2011.11.002
AbstractThe identification of cancer genes in sporadic cancers has been recognized as a major challenge in the field. It is clear that deletion mapping, genomic sequencing, comparative genomic hybridization, or global gene expression profiling alone would not have easily identified candidate tumor suppressor genes (TSGs) from the huge array of lost regions or genes observed in nasopharyngeal carcinoma (NPC). In addition, the epigenetically silenced genes would not have been recognized by the mapping of deleted regions. In this review, we describe how functional approaches using monochromosome transfer may be used to circumvent the above problems and identify TSGs in NPC. A few examples of selected NPC TSGs and their functional roles are reviewed. They regulate a variety of gene functions including cell growth and proliferation, adhesion, migration, invasion, epithelial-mesenchymal transition, metastasis, and angiogenesis. These studies show the advantages of using functional approaches for identification of TSGs. © 2011 Elsevier Ltd.
ISSN1044-579X
2011 Impact Factor: 6.475
2011 SCImago Journal Rankings: 1.288
DOIhttp://dx.doi.org/10.1016/j.semcancer.2011.11.002
ISI Accession Number IDWOS:000302450100003
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 661708M
HKU 661507M
HKUST 6611204M
Central Allocation GrantCA03/04.SC01
University Grants CouncilAoE/M-06/08
Funding Information:

Hong Kong Research Grants Council General Research Grants HKU 661708M, HKU 661507M, HKUST 6611204M and Central Allocation Grant CA03/04.SC01 and University Grants Council Area of Excellence Grant AoE/M-06/08 to M.L.L.

ReferencesReferences in Scopus
GrantsCentre for Nasopharyngeal Carcinoma Research
Molecular and functional studies of the role of chromosome 14q candidate genes, CRIP2 and MIPOL1, in nasopharyngeal and esophageal carcinomas
Molecular and Functional Investigation of the Role of Two Metalloproteinases in Nasopharyngeal Carcinoma Tumorigenesis
DC Field
Value
dc.contributor.authorLung, HL
dc.contributor.authorCheung, AKL
dc.contributor.authorKo, JMY
dc.contributor.authorCheng, Y
dc.contributor.authorStanbridge, EJ
dc.contributor.authorLung, ML
dc.date.accessioned2012-06-26T06:12:33Z
dc.date.available2012-06-26T06:12:33Z
dc.date.issued2012
dc.description.abstractThe identification of cancer genes in sporadic cancers has been recognized as a major challenge in the field. It is clear that deletion mapping, genomic sequencing, comparative genomic hybridization, or global gene expression profiling alone would not have easily identified candidate tumor suppressor genes (TSGs) from the huge array of lost regions or genes observed in nasopharyngeal carcinoma (NPC). In addition, the epigenetically silenced genes would not have been recognized by the mapping of deleted regions. In this review, we describe how functional approaches using monochromosome transfer may be used to circumvent the above problems and identify TSGs in NPC. A few examples of selected NPC TSGs and their functional roles are reviewed. They regulate a variety of gene functions including cell growth and proliferation, adhesion, migration, invasion, epithelial-mesenchymal transition, metastasis, and angiogenesis. These studies show the advantages of using functional approaches for identification of TSGs. © 2011 Elsevier Ltd.
dc.description.grantCentre for Nasopharyngeal Carcinoma Research
dc.description.grantMolecular and functional studies of the role of chromosome 14q candidate genes, CRIP2 and MIPOL1, in nasopharyngeal and esophageal carcinomas
dc.description.grantMolecular and Functional Investigation of the Role of Two Metalloproteinases in Nasopharyngeal Carcinoma Tumorigenesis
dc.description.grantcode101179
dc.description.grantcode100056
dc.description.grantcode99575
dc.description.natureLink_to_OA_fulltext
dc.identifier.citationSeminars in Cancer Biology, 2012, v. 22 n. 2, p. 87-95 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.semcancer.2011.11.002
dc.identifier.citeulike10259371
dc.identifier.doihttp://dx.doi.org/10.1016/j.semcancer.2011.11.002
dc.identifier.epage95
dc.identifier.hkuros199895
dc.identifier.isiWOS:000302450100003
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 661708M
HKU 661507M
HKUST 6611204M
Central Allocation GrantCA03/04.SC01
University Grants CouncilAoE/M-06/08
Funding Information:

Hong Kong Research Grants Council General Research Grants HKU 661708M, HKU 661507M, HKUST 6611204M and Central Allocation Grant CA03/04.SC01 and University Grants Council Area of Excellence Grant AoE/M-06/08 to M.L.L.

dc.identifier.issn1044-579X
2011 Impact Factor: 6.475
2011 SCImago Journal Rankings: 1.288
dc.identifier.issue2
dc.identifier.pmid22154888
dc.identifier.scopuseid_2-s2.0-84857786329
dc.identifier.spage87
dc.identifier.urihttp://hdl.handle.net/10722/150852
dc.identifier.volume22
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
dc.publisher.placeUnited Kingdom
dc.relation.ispartofSeminars in Cancer Biology
dc.relation.referencesReferences in Scopus
dc.subjectMicrocell Hybrid
dc.subjectMicrocell-Mediated Chromosome Transfer
dc.subjectNasopharyngeal Carcinoma
dc.subjectTumor Segregant
dc.subjectTumor Suppressor Gene
dc.titleDeciphering the molecular genetic basis of NPC through functional approaches
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. UC Irvine