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Article: Deciphering the molecular genetic basis of NPC through functional approaches
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TitleDeciphering the molecular genetic basis of NPC through functional approaches
 
AuthorsLung, HL1
Cheung, AKL1
Ko, JMY1
Cheng, Y1
Stanbridge, EJ2
Lung, ML1
 
KeywordsMicrocell hybrid
Microcell-mediated chromosome transfer
Nasopharyngeal carcinoma
Tumor segregant
Tumor suppressor gene
 
Issue Date2012
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
 
CitationSeminars In Cancer Biology, 2012, v. 22 n. 2, p. 87-95 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.semcancer.2011.11.002
 
AbstractThe identification of cancer genes in sporadic cancers has been recognized as a major challenge in the field. It is clear that deletion mapping, genomic sequencing, comparative genomic hybridization, or global gene expression profiling alone would not have easily identified candidate tumor suppressor genes (TSGs) from the huge array of lost regions or genes observed in nasopharyngeal carcinoma (NPC). In addition, the epigenetically silenced genes would not have been recognized by the mapping of deleted regions. In this review, we describe how functional approaches using monochromosome transfer may be used to circumvent the above problems and identify TSGs in NPC. A few examples of selected NPC TSGs and their functional roles are reviewed. They regulate a variety of gene functions including cell growth and proliferation, adhesion, migration, invasion, epithelial-mesenchymal transition, metastasis, and angiogenesis. These studies show the advantages of using functional approaches for identification of TSGs. © 2011 Elsevier Ltd.
 
ISSN1044-579X
2013 Impact Factor: 9.143
 
DOIhttp://dx.doi.org/10.1016/j.semcancer.2011.11.002
 
ISI Accession Number IDWOS:000302450100003
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 661708M
HKU 661507M
HKUST 6611204M
Central Allocation GrantCA03/04.SC01
University Grants CouncilAoE/M-06/08
Funding Information:

Hong Kong Research Grants Council General Research Grants HKU 661708M, HKU 661507M, HKUST 6611204M and Central Allocation Grant CA03/04.SC01 and University Grants Council Area of Excellence Grant AoE/M-06/08 to M.L.L.

 
ReferencesReferences in Scopus
 
GrantsCentre for Nasopharyngeal Carcinoma Research
Molecular and functional studies of the role of chromosome 14q candidate genes, CRIP2 and MIPOL1, in nasopharyngeal and esophageal carcinomas
Molecular and Functional Investigation of the Role of Two Metalloproteinases in Nasopharyngeal Carcinoma Tumorigenesis
 
DC FieldValue
dc.contributor.authorLung, HL
 
dc.contributor.authorCheung, AKL
 
dc.contributor.authorKo, JMY
 
dc.contributor.authorCheng, Y
 
dc.contributor.authorStanbridge, EJ
 
dc.contributor.authorLung, ML
 
dc.date.accessioned2012-06-26T06:12:33Z
 
dc.date.available2012-06-26T06:12:33Z
 
dc.date.issued2012
 
dc.description.abstractThe identification of cancer genes in sporadic cancers has been recognized as a major challenge in the field. It is clear that deletion mapping, genomic sequencing, comparative genomic hybridization, or global gene expression profiling alone would not have easily identified candidate tumor suppressor genes (TSGs) from the huge array of lost regions or genes observed in nasopharyngeal carcinoma (NPC). In addition, the epigenetically silenced genes would not have been recognized by the mapping of deleted regions. In this review, we describe how functional approaches using monochromosome transfer may be used to circumvent the above problems and identify TSGs in NPC. A few examples of selected NPC TSGs and their functional roles are reviewed. They regulate a variety of gene functions including cell growth and proliferation, adhesion, migration, invasion, epithelial-mesenchymal transition, metastasis, and angiogenesis. These studies show the advantages of using functional approaches for identification of TSGs. © 2011 Elsevier Ltd.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationSeminars In Cancer Biology, 2012, v. 22 n. 2, p. 87-95 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.semcancer.2011.11.002
 
dc.identifier.citeulike10259371
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.semcancer.2011.11.002
 
dc.identifier.epage95
 
dc.identifier.hkuros199895
 
dc.identifier.isiWOS:000302450100003
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 661708M
HKU 661507M
HKUST 6611204M
Central Allocation GrantCA03/04.SC01
University Grants CouncilAoE/M-06/08
Funding Information:

Hong Kong Research Grants Council General Research Grants HKU 661708M, HKU 661507M, HKUST 6611204M and Central Allocation Grant CA03/04.SC01 and University Grants Council Area of Excellence Grant AoE/M-06/08 to M.L.L.

 
dc.identifier.issn1044-579X
2013 Impact Factor: 9.143
 
dc.identifier.issue2
 
dc.identifier.pmid22154888
 
dc.identifier.scopuseid_2-s2.0-84857786329
 
dc.identifier.spage87
 
dc.identifier.urihttp://hdl.handle.net/10722/150852
 
dc.identifier.volume22
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofSeminars in Cancer Biology
 
dc.relation.projectCentre for Nasopharyngeal Carcinoma Research
 
dc.relation.projectMolecular and functional studies of the role of chromosome 14q candidate genes, CRIP2 and MIPOL1, in nasopharyngeal and esophageal carcinomas
 
dc.relation.projectMolecular and Functional Investigation of the Role of Two Metalloproteinases in Nasopharyngeal Carcinoma Tumorigenesis
 
dc.relation.referencesReferences in Scopus
 
dc.subjectMicrocell hybrid
 
dc.subjectMicrocell-mediated chromosome transfer
 
dc.subjectNasopharyngeal carcinoma
 
dc.subjectTumor segregant
 
dc.subjectTumor suppressor gene
 
dc.titleDeciphering the molecular genetic basis of NPC through functional approaches
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. UC Irvine