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Article: Chemically-induced cancers do not originate from bone marrow-derived cells

TitleChemically-induced cancers do not originate from bone marrow-derived cells
Authors
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 1, article no. e30493 How to Cite?
Abstract
BACKGROUND: The identification and characterization of cancer stem cells (CSCs) is imperative to understanding the mechanism of cancer pathogenesis. Growing evidence suggests that CSCs play critical roles in the development and progression of cancer. However, controversy exists as to whether CSCs arise from bone marrow-derived cells (BMDCs). METHODOLOGY AND PRINCIPAL FINDINGS: In the present study, n-nitrosodiethylamine (DEN) was used to induce tumor formation in female mice that received bone marrow from male mice. Tumor formation was induced in 20/26 mice, including 12 liver tumors, 6 lung tumors, 1 bladder tumor and 1 nasopharyngeal tumor. Through comparison of fluorescence in situ hybridization (FISH) results in corresponding areas from serial tumor sections stained with HandE, we determined that BMDCs were recruited to both tumor tissue and normal surrounding tissue at a very low frequency (0.2-1% in tumors and 0-0.3% in normal tissues). However, approximately 3-70% of cells in the tissues surrounding the tumor were BMDCs, and the percentage of BMDCs was highly associated with the inflammatory status of the tissue. In the present study, no evidence was found to support the existence of fusion cells formed form BMDCs and tissue-specific stem cells. CONCLUSIONS: In summary, our data suggest that although BMDCs may contribute to tumor progression, they are unlike to contribute to tumor initiation.
Persistent Identifierhttp://hdl.handle.net/10722/150847
ISSN
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Zhejiang Provincial Natural Science Foundation of ChinaY2100464
National Key Sci-Tech Special Project of Infectious Diseases2012ZX10002-013
Funding Information:

This work was supported by Zhejiang Provincial Natural Science Foundation of China (Y2100464) and the National Key Sci-Tech Special Project of Infectious Diseases (2012ZX10002-013). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorLin, Hen_US
dc.contributor.authorHu, Len_US
dc.contributor.authorChen, Len_US
dc.contributor.authorYu, Hen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorChen, Pen_US
dc.contributor.authorHu, XTen_US
dc.contributor.authorCai, XJen_US
dc.contributor.authorGuan, XYen_US
dc.date.accessioned2012-06-26T06:12:10Z-
dc.date.available2012-06-26T06:12:10Z-
dc.date.issued2012en_US
dc.identifier.citationPLoS One, 2012, v. 7 n. 1, article no. e30493en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/150847-
dc.description.abstractBACKGROUND: The identification and characterization of cancer stem cells (CSCs) is imperative to understanding the mechanism of cancer pathogenesis. Growing evidence suggests that CSCs play critical roles in the development and progression of cancer. However, controversy exists as to whether CSCs arise from bone marrow-derived cells (BMDCs). METHODOLOGY AND PRINCIPAL FINDINGS: In the present study, n-nitrosodiethylamine (DEN) was used to induce tumor formation in female mice that received bone marrow from male mice. Tumor formation was induced in 20/26 mice, including 12 liver tumors, 6 lung tumors, 1 bladder tumor and 1 nasopharyngeal tumor. Through comparison of fluorescence in situ hybridization (FISH) results in corresponding areas from serial tumor sections stained with HandE, we determined that BMDCs were recruited to both tumor tissue and normal surrounding tissue at a very low frequency (0.2-1% in tumors and 0-0.3% in normal tissues). However, approximately 3-70% of cells in the tissues surrounding the tumor were BMDCs, and the percentage of BMDCs was highly associated with the inflammatory status of the tissue. In the present study, no evidence was found to support the existence of fusion cells formed form BMDCs and tissue-specific stem cells. CONCLUSIONS: In summary, our data suggest that although BMDCs may contribute to tumor progression, they are unlike to contribute to tumor initiation.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBone Marrow Cells - pathology-
dc.subject.meshCarcinogens-
dc.subject.meshCell Transformation, Neoplastic - pathology-
dc.subject.meshNeoplasms - chemically induced - epidemiology - pathology-
dc.subject.meshNeoplastic Stem Cells - drug effects - pathology-
dc.titleChemically-induced cancers do not originate from bone marrow-derived cellsen_US
dc.typeArticleen_US
dc.identifier.emailHu, L: lhuc@hku.hken_US
dc.identifier.emailChen, L: pollyllc@hku.hk-
dc.identifier.emailCai, XJ: cxjzu@zju.edu.cn-
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hk-
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0030493en_US
dc.identifier.pmid22291966-
dc.identifier.pmcidPMC3265477-
dc.identifier.scopuseid_2-s2.0-84856202914en_US
dc.identifier.hkuros203478-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856202914&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue1, article no. e30493en_US
dc.identifier.isiWOS:000301639600026-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridCai, XJ=54918113200en_US
dc.identifier.scopusauthoridHu, XT=54918283400en_US
dc.identifier.scopusauthoridChen, P=54919576300en_US
dc.identifier.scopusauthoridWang, Q=54916036100en_US
dc.identifier.scopusauthoridYu, H=36349449900en_US
dc.identifier.scopusauthoridChen, L=54920985200en_US
dc.identifier.scopusauthoridHu, L=34770075600en_US
dc.identifier.scopusauthoridLin, H=54914930100en_US

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