Article: Dynamic PET-CT studies for characterizing nasopharyngeal carcinoma metabolism: comparison of analytical methods
| Title | Dynamic PET-CT studies for characterizing nasopharyngeal carcinoma metabolism: comparison of analytical methods | ||||
|---|---|---|---|---|---|
| Authors | Huang, B2 Khong, PL2 Kwong, DLW3 Hung, B1 Wong, CS2 Wong, CYO1 | ||||
| Issue Date | 2012 | ||||
| Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmedicinecomm.com | ||||
| Citation | Nuclear Medicine Communications, 2012, v. 33 n. 2, p. 191-197 [How to Cite?] DOI: http://dx.doi.org/10.1097/MNM.0b013e32834dfa0c | ||||
| Abstract | OBJECTIVES: To investigate the optimal PET protocol and analytical method to characterize the glucose metabolism in nasopharyngeal carcinoma (NPC). METHODS: Newly diagnosed NPC patients were recruited and a dynamic PET-CT scan was performed. The optimized threshold to derive the arterial input function (AIF) was studied. Two-tissue compartmental kinetic modeling using three, four, and five parameters, Patlak graphical analysis, and time sensitivity (S-factor) analysis were performed. The best compartmental model was determined in terms of goodness of fit, and correlated with Ki from Patlak graphical analysis and the S-factor. The methods with R>0.9 and P<0.05 were considered acceptable. The protocols using two static scans with its retention index (RI=(SUV(2)/SUV(1)-1)x100%, where SUV is the standardized uptake value) were also studied and compared with S-factor analysis. RESULTS: The best threshold of 0.6 was determined and used to derive AIF. The kinetic model with five parameters yields the best statistical results, but the model with k4=0 was used as the gold standard. All Ki values and some S-factors from data between various intervals (10-30, 10-45, 15-30, 15-45, 20-30, and 20-45 min) fulfilled the criteria. The RIs calculated from the S-factor were highly correlated to RI derived from simple two-point static scans at 10 and 30 min (R=0.9, P<0.0001). CONCLUSION: The Patlak graphical analyses and even a 20-min-interval S-factor analysis or simple two-point static scans were shown to be sufficient to characterize NPC metabolism, confirming the clinical feasibility of applying a short dynamic with image-derived AIF or simple two-point static PET scans for studying NPC. | ||||
| ISSN | 0143-3636 2011 Impact Factor: 1.404 2011 SCImago Journal Rankings: 0.117 | ||||
| DOI | http://dx.doi.org/10.1097/MNM.0b013e32834dfa0c | ||||
| ISI Accession Number ID | WOS:000299649300011
Funding Information: The study was partially funded by Hong Kong University Grants Council Area of Excellence scheme (AoE/M-06/08) and Small Project Funding scheme. | ||||
| References | References in Scopus | ||||
| Grants | Centre for Nasopharyngeal Carcinoma Research |
| dc.contributor.author | Huang, B | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Khong, PL | ||||
| dc.contributor.author | Kwong, DLW | ||||
| dc.contributor.author | Hung, B | ||||
| dc.contributor.author | Wong, CS | ||||
| dc.contributor.author | Wong, CYO | ||||
| dc.date.accessioned | 2012-06-26T06:12:09Z | ||||
| dc.date.available | 2012-06-26T06:12:09Z | ||||
| dc.date.issued | 2012 | ||||
| dc.description.abstract | OBJECTIVES: To investigate the optimal PET protocol and analytical method to characterize the glucose metabolism in nasopharyngeal carcinoma (NPC). METHODS: Newly diagnosed NPC patients were recruited and a dynamic PET-CT scan was performed. The optimized threshold to derive the arterial input function (AIF) was studied. Two-tissue compartmental kinetic modeling using three, four, and five parameters, Patlak graphical analysis, and time sensitivity (S-factor) analysis were performed. The best compartmental model was determined in terms of goodness of fit, and correlated with Ki from Patlak graphical analysis and the S-factor. The methods with R>0.9 and P<0.05 were considered acceptable. The protocols using two static scans with its retention index (RI=(SUV(2)/SUV(1)-1)x100%, where SUV is the standardized uptake value) were also studied and compared with S-factor analysis. RESULTS: The best threshold of 0.6 was determined and used to derive AIF. The kinetic model with five parameters yields the best statistical results, but the model with k4=0 was used as the gold standard. All Ki values and some S-factors from data between various intervals (10-30, 10-45, 15-30, 15-45, 20-30, and 20-45 min) fulfilled the criteria. The RIs calculated from the S-factor were highly correlated to RI derived from simple two-point static scans at 10 and 30 min (R=0.9, P<0.0001). CONCLUSION: The Patlak graphical analyses and even a 20-min-interval S-factor analysis or simple two-point static scans were shown to be sufficient to characterize NPC metabolism, confirming the clinical feasibility of applying a short dynamic with image-derived AIF or simple two-point static PET scans for studying NPC. | ||||
| dc.description.grant | Centre for Nasopharyngeal Carcinoma Research | ||||
| dc.description.grantcode | 101179 | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Nuclear Medicine Communications, 2012, v. 33 n. 2, p. 191-197 [How to Cite?] DOI: http://dx.doi.org/10.1097/MNM.0b013e32834dfa0c | ||||
| dc.identifier.doi | http://dx.doi.org/10.1097/MNM.0b013e32834dfa0c | ||||
| dc.identifier.epage | 197 | ||||
| dc.identifier.hkuros | 206679 | ||||
| dc.identifier.isi | WOS:000299649300011
Funding Information: The study was partially funded by Hong Kong University Grants Council Area of Excellence scheme (AoE/M-06/08) and Small Project Funding scheme. | ||||
| dc.identifier.issn | 0143-3636 2011 Impact Factor: 1.404 2011 SCImago Journal Rankings: 0.117 | ||||
| dc.identifier.issue | 2 | ||||
| dc.identifier.pmid | 22107997 | ||||
| dc.identifier.scopus | eid_2-s2.0-84855193471 | ||||
| dc.identifier.spage | 191 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/150846 | ||||
| dc.identifier.volume | 33 | ||||
| dc.language | eng | ||||
| dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmedicinecomm.com | ||||
| dc.publisher.place | United States | ||||
| dc.relation.ispartof | Nuclear Medicine Communications | ||||
| dc.relation.references | References in Scopus | ||||
| dc.subject.mesh | Algorithms | ||||
| dc.subject.mesh | Fluorodeoxyglucose F18 - diagnostic use - pharmacokinetics | ||||
| dc.subject.mesh | Nasopharyngeal Neoplasms - metabolism - radionuclide imaging | ||||
| dc.subject.mesh | Positron-Emission Tomography and Computed Tomography - methods | ||||
| dc.subject.mesh | Radiopharmaceuticals - diagnostic use - pharmacokinetics | ||||
| dc.title | Dynamic PET-CT studies for characterizing nasopharyngeal carcinoma metabolism: comparison of analytical methods | ||||
| dc.type | Article |
Author Affiliations
- Oakland University
- The University of Hong Kong
- Queen Mary Hospital Hong Kong