Article: High expression of p300 in human breast cancer correlates with tumor recurrence and predicts adverse prognosis
| Title | High expression of p300 in human breast cancer correlates with tumor recurrence and predicts adverse prognosis | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Xiao, XS1 Cai, MY1 Chen, JW1 Guan, XY1 Kung, HF1 2 Zeng, YX1 Xie, D1 | ||||||
| Keywords | Breast Cancer P300 Prognosis Tumor Recurrence | ||||||
| Issue Date | 2011 | ||||||
| Publisher | China Anti-Cancer Association. The Journal's web site is located at http://zgazyj.periodicals.net.cn/ | ||||||
| Citation | Chinese Journal Of Cancer Research, 2011, v. 23 n. 3, p. 201-207 [How to Cite?] DOI: http://dx.doi.org/10.1007/s11670-011-0201-5 | ||||||
| Abstract | Objective: Transcriptional coactivator p300 has been shown to play a variety of roles in the transcription process and mutation of p300 has been found in certain types of human cancers. However, the expression dynamics of p300 in breast cancer (BC) and its effect on BC patients' prognosis are poorly understood. Methods: In the present study, the methods of tissue microarray and immunohistochemistry (IHC) were used to investigate the protein expression of p300 in BCs. Receiver operating characteristic (ROC) curve analysis, Spearman's rank correlation, Kaplan-Meier plots and Cox proportional hazards regression model were utilized to analyze the data. Results: Based on the ROC curve analysis, the cutoff value for p300 high expression was defined when the H score for p300 was more than 105. High expression of p300 could be observed in 105/193 (54.4%) of BCs, in 6/25 (24.0%) of non-malignant breast tissues, respectively (P=0.004). Further correlation analysis showed that high expression of p300 was positively correlated with higher histological grade, advanced clinical stage and tumor recurrence (P<0.05). In univariate survival analysis, a significant association between high expression of p300 and shortened patients' survival and poor progression-free survival was found (P<0.05). Importantly, p300 expression was evaluated as an independent prognostic factor in multivariate analysis (P<0.05). Conclusion: Our findings provide a basis for the concept that high expression of p300 in BC may be important in the acquisition of a recurrence phenotype, suggesting that p300 high expression, as examined by IHC, is an independent biomarker for poor prognosis of patients with BC. © 2011 Chinese Anti-Cancer Association and Springer-Verlag Berlin Heidelberg. | ||||||
| ISSN | 1000-9604 2011 Impact Factor: 0.182 2011 SCImago Journal Rankings: 0.033 | ||||||
| DOI | http://dx.doi.org/10.1007/s11670-011-0201-5 | ||||||
| ISI Accession Number ID | WOS:000297246600007
Funding Information: This work was supported by a grant from the National Natural Science Foundation of China (No. 30901709), the National "973" Basic Research Program of China (No. 2010CB529400 and 2010CB912802). | ||||||
| References | References in Scopus |
| dc.contributor.author | Xiao, XS | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Cai, MY | ||||||
| dc.contributor.author | Chen, JW | ||||||
| dc.contributor.author | Guan, XY | ||||||
| dc.contributor.author | Kung, HF | ||||||
| dc.contributor.author | Zeng, YX | ||||||
| dc.contributor.author | Xie, D | ||||||
| dc.date.accessioned | 2012-06-26T06:12:03Z | ||||||
| dc.date.available | 2012-06-26T06:12:03Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Objective: Transcriptional coactivator p300 has been shown to play a variety of roles in the transcription process and mutation of p300 has been found in certain types of human cancers. However, the expression dynamics of p300 in breast cancer (BC) and its effect on BC patients' prognosis are poorly understood. Methods: In the present study, the methods of tissue microarray and immunohistochemistry (IHC) were used to investigate the protein expression of p300 in BCs. Receiver operating characteristic (ROC) curve analysis, Spearman's rank correlation, Kaplan-Meier plots and Cox proportional hazards regression model were utilized to analyze the data. Results: Based on the ROC curve analysis, the cutoff value for p300 high expression was defined when the H score for p300 was more than 105. High expression of p300 could be observed in 105/193 (54.4%) of BCs, in 6/25 (24.0%) of non-malignant breast tissues, respectively (P=0.004). Further correlation analysis showed that high expression of p300 was positively correlated with higher histological grade, advanced clinical stage and tumor recurrence (P<0.05). In univariate survival analysis, a significant association between high expression of p300 and shortened patients' survival and poor progression-free survival was found (P<0.05). Importantly, p300 expression was evaluated as an independent prognostic factor in multivariate analysis (P<0.05). Conclusion: Our findings provide a basis for the concept that high expression of p300 in BC may be important in the acquisition of a recurrence phenotype, suggesting that p300 high expression, as examined by IHC, is an independent biomarker for poor prognosis of patients with BC. © 2011 Chinese Anti-Cancer Association and Springer-Verlag Berlin Heidelberg. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Chinese Journal Of Cancer Research, 2011, v. 23 n. 3, p. 201-207 [How to Cite?] DOI: http://dx.doi.org/10.1007/s11670-011-0201-5 | ||||||
| dc.identifier.citeulike | 9763566 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1007/s11670-011-0201-5 | ||||||
| dc.identifier.epage | 207 | ||||||
| dc.identifier.isi | WOS:000297246600007
Funding Information: This work was supported by a grant from the National Natural Science Foundation of China (No. 30901709), the National "973" Basic Research Program of China (No. 2010CB529400 and 2010CB912802). | ||||||
| dc.identifier.issn | 1000-9604 2011 Impact Factor: 0.182 2011 SCImago Journal Rankings: 0.033 | ||||||
| dc.identifier.issue | 3 | ||||||
| dc.identifier.scopus | eid_2-s2.0-80052865221 | ||||||
| dc.identifier.spage | 201 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/150839 | ||||||
| dc.identifier.volume | 23 | ||||||
| dc.language | eng | ||||||
| dc.publisher | China Anti-Cancer Association. The Journal's web site is located at http://zgazyj.periodicals.net.cn/ | ||||||
| dc.publisher.place | China | ||||||
| dc.relation.ispartof | Chinese Journal of Cancer Research | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject | Breast Cancer | ||||||
| dc.subject | P300 | ||||||
| dc.subject | Prognosis | ||||||
| dc.subject | Tumor Recurrence | ||||||
| dc.title | High expression of p300 in human breast cancer correlates with tumor recurrence and predicts adverse prognosis | ||||||
| dc.type | Article |
Author Affiliations
- Sun Yat-Sen University Cancer Center
- Chinese University of Hong Kong