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Article: CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations

TitleCYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
Authors
Issue Date2008
Citation
Cancer Epidemiology Biomarkers And Prevention, 2008, v. 17 n. 5, p. 1120-1126 How to Cite?
AbstractTo evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This pooled analysis included 1,971 cases and 2,130 controls. Lung cancer riskwas estimated as odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 6235C variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; P trend = 0.003). In haplotype analysis, 462Val- 6235T and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk(OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer riskas pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with TT genotype (P interaction = 0.001) and with the GSTM1-null genotype compared with the present type (P interaction = 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer riskin Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking. Copyright © 2008 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/150824
ISSN
2015 Impact Factor: 3.622
2015 SCImago Journal Rankings: 2.579
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, KMen_US
dc.contributor.authorKang, Den_US
dc.contributor.authorClapper, MLen_US
dc.contributor.authorIngelmanSundberg, Men_US
dc.contributor.authorOnoKihara, Men_US
dc.contributor.authorKiyohara, Cen_US
dc.contributor.authorMin, Sen_US
dc.contributor.authorLan, Qen_US
dc.contributor.authorLe Marchand, Len_US
dc.contributor.authorLin, Pen_US
dc.contributor.authorLi Lung, Men_US
dc.contributor.authorPinarbasi, Hen_US
dc.contributor.authorPisani, Pen_US
dc.contributor.authorSrivatanakul, Pen_US
dc.contributor.authorSeow, Aen_US
dc.contributor.authorSugimura, Hen_US
dc.contributor.authorTokudome, Sen_US
dc.contributor.authorYokota, Jen_US
dc.contributor.authorTaioli, Een_US
dc.date.accessioned2012-06-26T06:11:32Z-
dc.date.available2012-06-26T06:11:32Z-
dc.date.issued2008en_US
dc.identifier.citationCancer Epidemiology Biomarkers And Prevention, 2008, v. 17 n. 5, p. 1120-1126en_US
dc.identifier.issn1055-9965en_US
dc.identifier.urihttp://hdl.handle.net/10722/150824-
dc.description.abstractTo evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This pooled analysis included 1,971 cases and 2,130 controls. Lung cancer riskwas estimated as odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 6235C variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; P trend = 0.003). In haplotype analysis, 462Val- 6235T and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk(OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer riskas pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with TT genotype (P interaction = 0.001) and with the GSTM1-null genotype compared with the present type (P interaction = 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer riskin Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking. Copyright © 2008 American Association for Cancer Research.en_US
dc.languageengen_US
dc.relation.ispartofCancer Epidemiology Biomarkers and Preventionen_US
dc.titleCYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populationsen_US
dc.typeArticleen_US
dc.identifier.emailLi Lung, M:mlilung@hku.hken_US
dc.identifier.authorityLi Lung, M=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1158/1055-9965.EPI-07-2786en_US
dc.identifier.pmid18463401-
dc.identifier.scopuseid_2-s2.0-52649148138en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-52649148138&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue5en_US
dc.identifier.spage1120en_US
dc.identifier.epage1126en_US
dc.identifier.isiWOS:000256012800016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, KM=26642943400en_US
dc.identifier.scopusauthoridKang, D=7402889335en_US
dc.identifier.scopusauthoridClapper, ML=7005163671en_US
dc.identifier.scopusauthoridIngelmanSundberg, M=7101739504en_US
dc.identifier.scopusauthoridOnoKihara, M=25223715500en_US
dc.identifier.scopusauthoridKiyohara, C=7005966447en_US
dc.identifier.scopusauthoridMin, S=25223796000en_US
dc.identifier.scopusauthoridLan, Q=23970641100en_US
dc.identifier.scopusauthoridLe Marchand, L=7006229986en_US
dc.identifier.scopusauthoridLin, P=8960773100en_US
dc.identifier.scopusauthoridLi Lung, M=7006411788en_US
dc.identifier.scopusauthoridPinarbasi, H=6602428486en_US
dc.identifier.scopusauthoridPisani, P=7006949543en_US
dc.identifier.scopusauthoridSrivatanakul, P=6701499809en_US
dc.identifier.scopusauthoridSeow, A=7004099964en_US
dc.identifier.scopusauthoridSugimura, H=7103031997en_US
dc.identifier.scopusauthoridTokudome, S=7006179933en_US
dc.identifier.scopusauthoridYokota, J=7102553031en_US
dc.identifier.scopusauthoridTaioli, E=7005607233en_US
dc.identifier.citeulike5143414-

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