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Article: Quantitative analysis of plasma cell-free Epstein-Barr virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy: A prospective study

TitleQuantitative analysis of plasma cell-free Epstein-Barr virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy: A prospective study
Authors
KeywordsCell-free
Epstein-Barr virus, DNA
Surgery
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2004, v. 26 n. 10, p. 878-883 How to Cite?
AbstractBackground. The quantity of circulating cell-free Epstein-Barr virus (EBV) DNA in patients with nasopharyngeal carcinoma (NPC) managed by radiotherapy has prognostic relevance. We measured the copy number of EBV DNA in patients with early recurrent NPC before and after salvage nasopharyngectomy. Methods. Nasopharyngectomy with the maxillary swing approach was performed for 28 patients. Serum blood samples were taken prospectively before nasopharyngectomy and on postoperative day 7. Plasma cell-free EBV DNA copies were measured with a real-time quantitative polymerase chain reaction for the BamHI-W fragment of the EBV genome. Results. Cell-free EBV DNA was detected in 17 patients before nasopharyngectomy. Surgical resection reduced the copy number of EBV DNA significantly (p = .016). Negative surgical margins achieved during nasopharyngectomy is associated with a zero EBV DNA copy postoperatively (p = .022). Conclusion. Cell-free EBV DNA was detected in 61% of patients with recurrent NPC, and its quantity postoperatively reflects whether the salvage nasopharyngectomy has achieved a negative surgical margin © 2004 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/150821
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWei, WIen_HK
dc.contributor.authorYuen, APWen_HK
dc.contributor.authorNg, RWMen_HK
dc.contributor.authorHo, WKen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorSham, JSTen_HK
dc.date.accessioned2012-06-26T06:11:17Z-
dc.date.available2012-06-26T06:11:17Z-
dc.date.issued2004en_HK
dc.identifier.citationHead And Neck, 2004, v. 26 n. 10, p. 878-883en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150821-
dc.description.abstractBackground. The quantity of circulating cell-free Epstein-Barr virus (EBV) DNA in patients with nasopharyngeal carcinoma (NPC) managed by radiotherapy has prognostic relevance. We measured the copy number of EBV DNA in patients with early recurrent NPC before and after salvage nasopharyngectomy. Methods. Nasopharyngectomy with the maxillary swing approach was performed for 28 patients. Serum blood samples were taken prospectively before nasopharyngectomy and on postoperative day 7. Plasma cell-free EBV DNA copies were measured with a real-time quantitative polymerase chain reaction for the BamHI-W fragment of the EBV genome. Results. Cell-free EBV DNA was detected in 17 patients before nasopharyngectomy. Surgical resection reduced the copy number of EBV DNA significantly (p = .016). Negative surgical margins achieved during nasopharyngectomy is associated with a zero EBV DNA copy postoperatively (p = .022). Conclusion. Cell-free EBV DNA was detected in 61% of patients with recurrent NPC, and its quantity postoperatively reflects whether the salvage nasopharyngectomy has achieved a negative surgical margin © 2004 Wiley Periodicals, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectCell-freeen_HK
dc.subjectEpstein-Barr virus, DNAen_HK
dc.subjectSurgeryen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma - Radiotherapy - Surgery - Virologyen_US
dc.subject.meshDna, Viral - Blooden_US
dc.subject.meshEpstein-Barr Virus Infections - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHerpesvirus 4, Human - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Radiotherapy - Surgery - Virologyen_US
dc.subject.meshNasopharynx - Surgeryen_US
dc.subject.meshNeoplasm Recurrence, Local - Surgery - Virologyen_US
dc.subject.meshPharyngectomy - Methodsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSalvage Therapyen_US
dc.titleQuantitative analysis of plasma cell-free Epstein-Barr virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy: A prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hed.20066en_HK
dc.identifier.pmid15390201-
dc.identifier.scopuseid_2-s2.0-4644227225en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4644227225&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue10en_HK
dc.identifier.spage878en_HK
dc.identifier.epage883en_HK
dc.identifier.isiWOS:000224173400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK
dc.identifier.scopusauthoridNg, RWM=7102153861en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK

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