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Article: Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage

TitleOverexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage
Authors
KeywordsAIB1
Amplification
Immunohistochemistry
Nasopharyngeal Carcinoma
Tissue Microarray
Issue Date2008
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 2008, v. 129 n. 5, p. 728-734 How to Cite?
AbstractAIB1, a candidate oncogene in breast cancer, is commonly amplified and overexpressed in several types of human cancers. In this study, expression and amplification of AIB1 in nasopharyngeal carcinoma (NPC) were studied by immunohistochemical analysis and fluorescence in situ hybridization using tissue microarrays, including 80 specimens of NPC and 20 specimens of nonneoplastic nasopharyngeal mucosa. In this NPC cohort, overexpression and amplification of AIB1 was detected in 36 (51%) of 71 and 3 (7%) of 46 NPCs, respectively. Overexpression of AIB1 was observed more frequently in NPCs in late T stages (T3/T4, 24/35 [69%]) than in earlier stages (T1/T2, 12/36 [33%]; P < .05). In addition, 18 (72%) of 25 NPCs with lymph node metastasis (N1-3) showed overexpression of AIB1; the frequency was significantly higher than that in NPCs without node metastasis (N0, 18/49 [39%]; P < .05). These findings suggest that overexpression of AIB1 in NPCs may be important in the acquisition of an invasive and/or metastatic phenotype. © American Society for Clinical Pathology.
Persistent Identifierhttp://hdl.handle.net/10722/150820
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, MZen_US
dc.contributor.authorXie, Den_US
dc.contributor.authorMai, SJen_US
dc.contributor.authorTong, ZTen_US
dc.contributor.authorShao, JYen_US
dc.contributor.authorFu, YSen_US
dc.contributor.authorXia, WJen_US
dc.contributor.authorKung, HFen_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorZeng, YXen_US
dc.date.accessioned2012-06-26T06:11:17Z-
dc.date.available2012-06-26T06:11:17Z-
dc.date.issued2008en_US
dc.identifier.citationAmerican Journal Of Clinical Pathology, 2008, v. 129 n. 5, p. 728-734en_US
dc.identifier.issn0002-9173en_US
dc.identifier.urihttp://hdl.handle.net/10722/150820-
dc.description.abstractAIB1, a candidate oncogene in breast cancer, is commonly amplified and overexpressed in several types of human cancers. In this study, expression and amplification of AIB1 in nasopharyngeal carcinoma (NPC) were studied by immunohistochemical analysis and fluorescence in situ hybridization using tissue microarrays, including 80 specimens of NPC and 20 specimens of nonneoplastic nasopharyngeal mucosa. In this NPC cohort, overexpression and amplification of AIB1 was detected in 36 (51%) of 71 and 3 (7%) of 46 NPCs, respectively. Overexpression of AIB1 was observed more frequently in NPCs in late T stages (T3/T4, 24/35 [69%]) than in earlier stages (T1/T2, 12/36 [33%]; P < .05). In addition, 18 (72%) of 25 NPCs with lymph node metastasis (N1-3) showed overexpression of AIB1; the frequency was significantly higher than that in NPCs without node metastasis (N0, 18/49 [39%]; P < .05). These findings suggest that overexpression of AIB1 in NPCs may be important in the acquisition of an invasive and/or metastatic phenotype. © American Society for Clinical Pathology.en_US
dc.languageengen_US
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_US
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_US
dc.subjectAIB1en_US
dc.subjectAmplificationen_US
dc.subjectImmunohistochemistryen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.subjectTissue Microarrayen_US
dc.titleOverexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stageen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1309/QMDTL82JKEX6E7H2en_US
dc.identifier.scopuseid_2-s2.0-44849122637en_US
dc.identifier.hkuros156534-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44849122637&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume129en_US
dc.identifier.issue5en_US
dc.identifier.spage728en_US
dc.identifier.epage734en_US
dc.identifier.isiWOS:000255133100006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiu, MZ=35285929300en_US
dc.identifier.scopusauthoridXie, D=35070710200en_US
dc.identifier.scopusauthoridMai, SJ=36780688900en_US
dc.identifier.scopusauthoridTong, ZT=36747652800en_US
dc.identifier.scopusauthoridShao, JY=7201362166en_US
dc.identifier.scopusauthoridFu, YS=51963656200en_US
dc.identifier.scopusauthoridXia, WJ=16508173000en_US
dc.identifier.scopusauthoridKung, HF=24341243600en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridZeng, YX=7402981579en_US

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