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Article: Vimentin supports mitochondrial morphology and organization

TitleVimentin supports mitochondrial morphology and organization
Authors
Issue Date2008
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 2008, v. 410 n. 1, p. 141-146 How to Cite?
AbstractVimentin is one of the intermediate filaments that functions in structural support, signal transduction and organelle positioning of a cell. In the present study, we report the contribution of vimentin in mitochondrial morphology and organization. Using subcellular fractionation, immunoprecipitation and fluorescence microscopy analyses, we found that vimentin was associated with mitochondria. Knockdown of vimentin resulted in mitochondrial fragmentation, swelling and disorganization. We further demonstrated that the vimentin cytoskeleton co-localized and interacted with mitochondria to a greater extent than other cytoskeletal components known to support mitochondria. Our results also suggest that vimentin could participate in the mitochondrial association of microtubules. As mitochondrial morphologies determine mitochondrial function, our findings revealed a potentially important relationship between the vimentin-based intermediate filaments and the regulation of mitochondria. © The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/150815
ISSN
2015 Impact Factor: 3.562
2015 SCImago Journal Rankings: 2.582
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, HLen_US
dc.contributor.authorLung, HLen_US
dc.contributor.authorWu, KCen_US
dc.contributor.authorLe, AHPen_US
dc.contributor.authorTang, HMen_US
dc.contributor.authorFung, MCen_US
dc.date.accessioned2012-06-26T06:11:07Z-
dc.date.available2012-06-26T06:11:07Z-
dc.date.issued2008en_US
dc.identifier.citationBiochemical Journal, 2008, v. 410 n. 1, p. 141-146en_US
dc.identifier.issn0264-6021en_US
dc.identifier.urihttp://hdl.handle.net/10722/150815-
dc.description.abstractVimentin is one of the intermediate filaments that functions in structural support, signal transduction and organelle positioning of a cell. In the present study, we report the contribution of vimentin in mitochondrial morphology and organization. Using subcellular fractionation, immunoprecipitation and fluorescence microscopy analyses, we found that vimentin was associated with mitochondria. Knockdown of vimentin resulted in mitochondrial fragmentation, swelling and disorganization. We further demonstrated that the vimentin cytoskeleton co-localized and interacted with mitochondria to a greater extent than other cytoskeletal components known to support mitochondria. Our results also suggest that vimentin could participate in the mitochondrial association of microtubules. As mitochondrial morphologies determine mitochondrial function, our findings revealed a potentially important relationship between the vimentin-based intermediate filaments and the regulation of mitochondria. © The Authors.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_US
dc.relation.ispartofBiochemical Journalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCell Lineen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshImmunoprecipitationen_US
dc.subject.meshMicroscopy, Fluorescenceen_US
dc.subject.meshMitochondria - Physiologyen_US
dc.subject.meshRna, Small Interferingen_US
dc.subject.meshVimentin - Physiologyen_US
dc.titleVimentin supports mitochondrial morphology and organizationen_US
dc.typeArticleen_US
dc.identifier.emailLung, HL:hllung2@hku.hken_US
dc.identifier.authorityLung, HL=rp00299en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1042/BJ20071072en_US
dc.identifier.pmid17983357-
dc.identifier.scopuseid_2-s2.0-39749136069en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39749136069&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume410en_US
dc.identifier.issue1en_US
dc.identifier.spage141en_US
dc.identifier.epage146en_US
dc.identifier.isiWOS:000253406400013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTang, HL=13608168100en_US
dc.identifier.scopusauthoridLung, HL=6603819904en_US
dc.identifier.scopusauthoridWu, KC=23669617600en_US
dc.identifier.scopusauthoridLe, AHP=36725359300en_US
dc.identifier.scopusauthoridTang, HM=35520308000en_US
dc.identifier.scopusauthoridFung, MC=13310394400en_US

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