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Article: Expressions of E-cadherin in non-small cell lung cancer and it correlation with prognosis

TitleExpressions of E-cadherin in non-small cell lung cancer and it correlation with prognosis
Authors
Issue Date2005
Citation
Zhonghua Wai Ke Za Zhi [Chinese Journal Of Surgery], 2005, v. 43 n. 14, p. 913-917 How to Cite?
AbstractOBJECTIVE: This study was to clarify E-cadherin expressions in non-small cell lung cancer (NSCLC) and its correlation with patients' prognosis. METHODS: Tissue microarrays (TMAs) containing specimens from 365 different NSCLC were constructed, covering all stages and almost all histological types of this disease. Slides were immunohistochemically stained with antibodies against E-cadherin. Expression pattern of the protein was analyzed with relation to the clinicopathological. Correlations of the results with patients' overall survival were also examined. RESULTS: Immunohistochemical staining revealed that E-cadherin protein was localized mainly on membranes and the cytoplasm of NSCLC tumors cells. Reduced E-cadherin expression was evident in 32.1%. Reduced E-cadherin expression significantly correlated with lymph nodes metastasis (chi(2) = 16.430, P = 0.001), histological dedifferentiation (chi(2) = 9.243, P = 0.010) and advanced clinical stage (chi(2) = 9.421, P = 0.024). There was no significant difference in E-cadherin expression between squamous cell carcinoma and adenocarcinoma. E-cadherin reduced expression correlated with a poor prognosis (P < 0.0001) in univariate analysis. Multivariate analysis showed a significantly lower survival probability for patients with reduced E-cadherin (P < 0.001), and E-cadherin was an independent prognostic factor for survival of NSCLC patients. CONCLUSIONS: It suggests that dysfunction of E-cadherin has an important impact in the progression of lung cancer. As an independent prognostic factor, expression of E-cadherin can predict outcome of different group, together with conventional prognostic factors, and subsequently make appropriate management.
Persistent Identifierhttp://hdl.handle.net/10722/150813
ISSN
2015 SCImago Journal Rankings: 0.133

 

DC FieldValueLanguage
dc.contributor.authorQiao, GBen_US
dc.contributor.authorWu, YLen_US
dc.contributor.authorOu, Wen_US
dc.contributor.authorYang, XNen_US
dc.contributor.authorZhong, WZen_US
dc.contributor.authorLin, JYen_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorXie, Den_US
dc.contributor.authorGuan, XYen_US
dc.date.accessioned2012-06-26T06:11:03Z-
dc.date.available2012-06-26T06:11:03Z-
dc.date.issued2005en_US
dc.identifier.citationZhonghua Wai Ke Za Zhi [Chinese Journal Of Surgery], 2005, v. 43 n. 14, p. 913-917en_US
dc.identifier.issn0529-5815en_US
dc.identifier.urihttp://hdl.handle.net/10722/150813-
dc.description.abstractOBJECTIVE: This study was to clarify E-cadherin expressions in non-small cell lung cancer (NSCLC) and its correlation with patients' prognosis. METHODS: Tissue microarrays (TMAs) containing specimens from 365 different NSCLC were constructed, covering all stages and almost all histological types of this disease. Slides were immunohistochemically stained with antibodies against E-cadherin. Expression pattern of the protein was analyzed with relation to the clinicopathological. Correlations of the results with patients' overall survival were also examined. RESULTS: Immunohistochemical staining revealed that E-cadherin protein was localized mainly on membranes and the cytoplasm of NSCLC tumors cells. Reduced E-cadherin expression was evident in 32.1%. Reduced E-cadherin expression significantly correlated with lymph nodes metastasis (chi(2) = 16.430, P = 0.001), histological dedifferentiation (chi(2) = 9.243, P = 0.010) and advanced clinical stage (chi(2) = 9.421, P = 0.024). There was no significant difference in E-cadherin expression between squamous cell carcinoma and adenocarcinoma. E-cadherin reduced expression correlated with a poor prognosis (P < 0.0001) in univariate analysis. Multivariate analysis showed a significantly lower survival probability for patients with reduced E-cadherin (P < 0.001), and E-cadherin was an independent prognostic factor for survival of NSCLC patients. CONCLUSIONS: It suggests that dysfunction of E-cadherin has an important impact in the progression of lung cancer. As an independent prognostic factor, expression of E-cadherin can predict outcome of different group, together with conventional prognostic factors, and subsequently make appropriate management.en_US
dc.languageengen_US
dc.relation.ispartofZhonghua wai ke za zhi [Chinese journal of surgery]en_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCadherins - Biosynthesisen_US
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Metabolism - Mortality - Secondaryen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLung Neoplasms - Metabolism - Mortality - Pathologyen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival Rateen_US
dc.titleExpressions of E-cadherin in non-small cell lung cancer and it correlation with prognosisen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16083620-
dc.identifier.scopuseid_2-s2.0-39049183042en_US
dc.identifier.volume43en_US
dc.identifier.issue14en_US
dc.identifier.spage913en_US
dc.identifier.epage917en_US
dc.identifier.scopusauthoridQiao, GB=8318743700en_US
dc.identifier.scopusauthoridWu, YL=8974511600en_US
dc.identifier.scopusauthoridOu, W=7007123676en_US
dc.identifier.scopusauthoridYang, XN=8318743600en_US
dc.identifier.scopusauthoridZhong, WZ=16065101400en_US
dc.identifier.scopusauthoridLin, JY=26028341200en_US
dc.identifier.scopusauthoridZhao, J=7410312185en_US
dc.identifier.scopusauthoridXie, D=35070710200en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US

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