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Article: Genomic changes in primary lesion and lymph node metastases of esophageal squamous cell carcinoma

TitleGenomic changes in primary lesion and lymph node metastases of esophageal squamous cell carcinoma
食管癌原發灶與淋巴結轉移灶細胞染色體變化特征的比較
Authors
Issue Date2005
PublisherSun Yat-sen University Cancer Center (中山醫科大學腫瘤防治中心). The Journal's web site is located at http://www.cjcsysu.cn/
Citation
Chinese Journal of Cancer, 2005, v. 24 n. 9, p. 1048-1053 How to Cite?
癌症, 2005, v. 24 n. 9, p. 1048-1053 How to Cite?
AbstractBACKGROUND & OBJECTIVE: Local lymph node and blood metastasis could occur at early stage of esophageal squamous cell carcinoma (ESCC), which may be the key factors of its recurrence and poor prognosis. However, the mechanism of ESCC metastasis is unclear. This study was to analyze the genetic changes in primary lesion and lymph node metastases of ESCC, to screen for and locate ESCC metastasis-related genes. METHODS: Genomic alterations in 15 pairs of primary lesions and matched metastatic lymph nodes of ESCC were analyzed by comparative genomic hybridization (CGH). RESULTS: In the 15 pairs of tissues, the most common chromosomal alterations were the gains of 3q, 8q, 6p, 20p, 5p, 18p, 2p, 2q and 1q, and the losses of 10p, 10q, 17p, 18q, 4p and 13q. Of these changes, the most significant finding was the gain of 6p with a frequency of 47% in metastatic lymph nodes and 13% in primary lesions, and the gain of 20p with a frequency of 73% in metastatic lymph nodes and 33% in primary lesions. The second interesting finding was the loss of 10p with a frequency of 53% in metastatic lymph nodes and 13% in primary lesions, and the loss of 10q with a frequency of 47% in metastatic lymph nodes and 13% in primary lesions. CONCLUSION: The gains of 6p and 20p and the losses of 10p and 10q are common genomic alterations in primary lesion and lymph node metastases of ESCC, which may code ESCC metastasis-related genes.
背景與目的:食管癌早期可發生局部淋巴或血行轉移,這是導致復發和預后差的主要原因。但是,食管癌轉移發生的分子機制尚不清楚。本研究旨在分析食管癌原發灶和淋巴結轉移灶腫瘤細胞染色體變化的特征,尋找或定位與食管癌轉移相關基因,加深對其轉移機制的了解。方法:應用比較基因組雜交技術(comparativegenomichybridization,CGH)分析15例食管癌患者原發灶和其對應的淋巴結轉移灶的染色體基因組改變。結果:最常見染色體DNA拷貝數增加的部位是3q,8q,6p,20p,5p,18p,2p,2q,1q;常見的染色體DNA拷貝數丟失的部位是10p,10q,17p,18q,4p,13q。其中,最有意義的發現是6p增加(原發灶:2/15,13%,轉移灶:7/15,47%),20p增加(原發灶:5/15,33.3%,轉移灶:11/15,73.3%)。第二個發現是10p丟失(原發灶:2/15,13.3%,轉移灶:8/15,53%),10q丟失(原發灶:2/15,13.3%,轉移灶:7/15,46.6%)。結論:食管癌原發灶和淋巴結轉移灶細胞染色體基因組改變最顯著的部位是6p,20p的增加和10p,10q的丟失;這些部位可能存在與食管癌細胞淋巴結轉移相關的基因。
Persistent Identifierhttp://hdl.handle.net/10722/150811
ISSN
2015 Impact Factor: 2.814
2015 SCImago Journal Rankings: 1.081

 

DC FieldValueLanguage
dc.contributor.authorQin, YRen_HK
dc.contributor.authorWang, LDen_HK
dc.contributor.authorDora, Ken_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorZhuang, ZHen_HK
dc.contributor.authorFan, ZMen_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorCao, SHen_HK
dc.date.accessioned2012-06-26T06:11:01Z-
dc.date.available2012-06-26T06:11:01Z-
dc.date.issued2005en_HK
dc.identifier.citationChinese Journal of Cancer, 2005, v. 24 n. 9, p. 1048-1053en_HK
dc.identifier.citation癌症, 2005, v. 24 n. 9, p. 1048-1053-
dc.identifier.issn1000-467Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/150811-
dc.description.abstractBACKGROUND & OBJECTIVE: Local lymph node and blood metastasis could occur at early stage of esophageal squamous cell carcinoma (ESCC), which may be the key factors of its recurrence and poor prognosis. However, the mechanism of ESCC metastasis is unclear. This study was to analyze the genetic changes in primary lesion and lymph node metastases of ESCC, to screen for and locate ESCC metastasis-related genes. METHODS: Genomic alterations in 15 pairs of primary lesions and matched metastatic lymph nodes of ESCC were analyzed by comparative genomic hybridization (CGH). RESULTS: In the 15 pairs of tissues, the most common chromosomal alterations were the gains of 3q, 8q, 6p, 20p, 5p, 18p, 2p, 2q and 1q, and the losses of 10p, 10q, 17p, 18q, 4p and 13q. Of these changes, the most significant finding was the gain of 6p with a frequency of 47% in metastatic lymph nodes and 13% in primary lesions, and the gain of 20p with a frequency of 73% in metastatic lymph nodes and 33% in primary lesions. The second interesting finding was the loss of 10p with a frequency of 53% in metastatic lymph nodes and 13% in primary lesions, and the loss of 10q with a frequency of 47% in metastatic lymph nodes and 13% in primary lesions. CONCLUSION: The gains of 6p and 20p and the losses of 10p and 10q are common genomic alterations in primary lesion and lymph node metastases of ESCC, which may code ESCC metastasis-related genes.en_HK
dc.description.abstract背景與目的:食管癌早期可發生局部淋巴或血行轉移,這是導致復發和預后差的主要原因。但是,食管癌轉移發生的分子機制尚不清楚。本研究旨在分析食管癌原發灶和淋巴結轉移灶腫瘤細胞染色體變化的特征,尋找或定位與食管癌轉移相關基因,加深對其轉移機制的了解。方法:應用比較基因組雜交技術(comparativegenomichybridization,CGH)分析15例食管癌患者原發灶和其對應的淋巴結轉移灶的染色體基因組改變。結果:最常見染色體DNA拷貝數增加的部位是3q,8q,6p,20p,5p,18p,2p,2q,1q;常見的染色體DNA拷貝數丟失的部位是10p,10q,17p,18q,4p,13q。其中,最有意義的發現是6p增加(原發灶:2/15,13%,轉移灶:7/15,47%),20p增加(原發灶:5/15,33.3%,轉移灶:11/15,73.3%)。第二個發現是10p丟失(原發灶:2/15,13.3%,轉移灶:8/15,53%),10q丟失(原發灶:2/15,13.3%,轉移灶:7/15,46.6%)。結論:食管癌原發灶和淋巴結轉移灶細胞染色體基因組改變最顯著的部位是6p,20p的增加和10p,10q的丟失;這些部位可能存在與食管癌細胞淋巴結轉移相關的基因。-
dc.languagechien_US
dc.publisherSun Yat-sen University Cancer Center (中山醫科大學腫瘤防治中心). The Journal's web site is located at http://www.cjcsysu.cn/-
dc.relation.ispartofChinese Journal of Canceren_HK
dc.relation.ispartof癌症-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Squamous Cell - Genetics - Pathologyen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human, Pair 10en_US
dc.subject.meshChromosomes, Human, Pair 20en_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshEsophageal Neoplasms - Genetics - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshHumansen_US
dc.subject.meshLymph Nodes - Pathologyen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNucleic Acid Hybridization - Methodsen_US
dc.titleGenomic changes in primary lesion and lymph node metastases of esophageal squamous cell carcinomaen_HK
dc.title食管癌原發灶與淋巴結轉移灶細胞染色體變化特征的比較-
dc.typeArticleen_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_HK
dc.identifier.emailCao, SH: gswtsao@hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityDeng, W=rp01640en_HK
dc.identifier.authorityCao, SH=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16159423-
dc.identifier.scopuseid_2-s2.0-34548689443en_HK
dc.identifier.volume24en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1048en_HK
dc.identifier.epage1053en_HK
dc.publisher.placeChina (中國)-
dc.identifier.scopusauthoridQin, YR=7403100680en_HK
dc.identifier.scopusauthoridWang, LD=12242861000en_HK
dc.identifier.scopusauthoridDora, K=23496349000en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridZhuang, ZH=7203003327en_HK
dc.identifier.scopusauthoridFan, ZM=7402099547en_HK
dc.identifier.scopusauthoridDeng, W=7202223673en_HK
dc.identifier.scopusauthoridCao, SH=7102813116en_HK
dc.customcontrol.immutablecsl 150112-

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