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Article: The association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chinese

TitleThe association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chinese
Authors
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cca
Citation
Clinica Chimica Acta, 2007, v. 380 n. 1-2, p. 191-196 How to Cite?
AbstractBackground: Cytochrome P450 (CYP) 2C9 is an important enzyme involved in xenobiotics metabolism. This study investigated the association of CYP2C9 gene coding region polymorphisms with colorectal cancer (CRC) in Chinese Han population. Methods: Four hundred and eighty-three healthy controls and 286 sporadic CRC patients participated in this study. Direct sequencing was used to identify the sequence polymorphisms. Results: We detected the significant association of 2 coding region SNPs, rs1057910 and rs1057911, of CYP2C9 with the risk of developing sporadic CRC for Han Chinese. These 2 SNPs showed a strong linkage disequilibrium (LD) (r 2 = 0.97, D′ = 0.985). Significantly different minor allele frequencies were found for SNPs rs1057910 and rs1057911 between the cases (7% and 7.2%, respectively) and controls (3% and 2.9%, respectively) with adjusted P = 0.0004 and 0.0002, respectively. Individuals heterozygous for rs1057910A/C or rs1057911A/T showed 2.589-fold (95% CI: 1.549-4.330) or 2.770-fold (95% CI 1.653-4.643) increased risk of developing sporadic CRC. We did not detect any homozygote minor allele carrier for either rs1057910 or rs1057911 in our study population. The CRC association appeared to be more evident for individuals over age 50 y, for men, and for rectum cancer site. Conclusion: There is an association of CYP2C9 coding region polymorphisms with the risk of developing CRC in Han Chinese after genotyping cases and controls recruited from different locations in China. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150808
ISSN
2015 Impact Factor: 2.799
2015 SCImago Journal Rankings: 1.040
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiao, LHen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorLai, MPen_US
dc.contributor.authorLau, KWen_US
dc.contributor.authorLai, AKCen_US
dc.contributor.authorZhang, JHen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorWei, Wen_US
dc.contributor.authorChai, JHen_US
dc.contributor.authorLung, MLen_US
dc.contributor.authorTai, SSWen_US
dc.contributor.authorWu, Men_US
dc.date.accessioned2012-06-26T06:10:54Z-
dc.date.available2012-06-26T06:10:54Z-
dc.date.issued2007en_US
dc.identifier.citationClinica Chimica Acta, 2007, v. 380 n. 1-2, p. 191-196en_US
dc.identifier.issn0009-8981en_US
dc.identifier.urihttp://hdl.handle.net/10722/150808-
dc.description.abstractBackground: Cytochrome P450 (CYP) 2C9 is an important enzyme involved in xenobiotics metabolism. This study investigated the association of CYP2C9 gene coding region polymorphisms with colorectal cancer (CRC) in Chinese Han population. Methods: Four hundred and eighty-three healthy controls and 286 sporadic CRC patients participated in this study. Direct sequencing was used to identify the sequence polymorphisms. Results: We detected the significant association of 2 coding region SNPs, rs1057910 and rs1057911, of CYP2C9 with the risk of developing sporadic CRC for Han Chinese. These 2 SNPs showed a strong linkage disequilibrium (LD) (r 2 = 0.97, D′ = 0.985). Significantly different minor allele frequencies were found for SNPs rs1057910 and rs1057911 between the cases (7% and 7.2%, respectively) and controls (3% and 2.9%, respectively) with adjusted P = 0.0004 and 0.0002, respectively. Individuals heterozygous for rs1057910A/C or rs1057911A/T showed 2.589-fold (95% CI: 1.549-4.330) or 2.770-fold (95% CI 1.653-4.643) increased risk of developing sporadic CRC. We did not detect any homozygote minor allele carrier for either rs1057910 or rs1057911 in our study population. The CRC association appeared to be more evident for individuals over age 50 y, for men, and for rectum cancer site. Conclusion: There is an association of CYP2C9 coding region polymorphisms with the risk of developing CRC in Han Chinese after genotyping cases and controls recruited from different locations in China. © 2007 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccaen_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.subject.meshAllelesen_US
dc.subject.meshAryl Hydrocarbon Hydroxylases - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshColorectal Neoplasms - Epidemiology - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHealth Surveysen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMedical Recordsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking - Adverse Effectsen_US
dc.titleThe association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cca.2007.02.033en_US
dc.identifier.pmid17368604-
dc.identifier.scopuseid_2-s2.0-34047117007en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34047117007&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume380en_US
dc.identifier.issue1-2en_US
dc.identifier.spage191en_US
dc.identifier.epage196en_US
dc.identifier.isiWOS:000246645500029-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLiao, LH=16175550800en_US
dc.identifier.scopusauthoridZhang, H=7409195750en_US
dc.identifier.scopusauthoridLai, MP=16175647300en_US
dc.identifier.scopusauthoridLau, KW=35080643000en_US
dc.identifier.scopusauthoridLai, AKC=16175547000en_US
dc.identifier.scopusauthoridZhang, JH=15051213900en_US
dc.identifier.scopusauthoridWang, Q=35304190700en_US
dc.identifier.scopusauthoridWei, W=35475294600en_US
dc.identifier.scopusauthoridChai, JH=7202678299en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.scopusauthoridTai, SSW=55197034800en_US
dc.identifier.scopusauthoridWu, M=8646305800en_US

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