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Article: Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma

TitleFunctional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma
Authors
KeywordsBLU/ZMYND10
Chromosome 3p21.3
Nasopharyngeal carcinoma
Tumor suppressor gene
Issue Date2006
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2006, v. 119 n. 12, p. 2821-2826 How to Cite?
AbstractChromosome 3p plays an important role in tumorigenesis in many cancers, including nasopharyngeal carcinoma (NPC). We have previously shown chromosome 3p can suppress tumor growth in vivo by using the monochromosome transfer approach, which indicated the chromosome 3p21.3 region was critical for tumor suppression. BLU/ZMYND10 is one of the candidate tumor suppressor genes mapping in the 3p21.3 critical region and is a candidate TSG for NPC. By quantitative RT-PCR, it is frequently downregulated in NPC cell lines (83%) and NPC biopsies (80%). However, no functional studies have yet verified the functional role of BLU/ZMYND10 as a tumor suppressor gene. In the current study, a gene inactivation test (GIT) utilizing a tetracycline regulation system was used to study the functional role of BLU/ZMYND10. When BLU/ZMYND10 is expressed in the absence of doxycycline, the stable transfectants were able to induce tumor suppression in nude mice. In contrast, downregulation of BLU/ZMYND10 in these tumor suppressive clones by doxycycline treatment restored the tumor formation ability. This study provides the first significant evidence to demonstrate BLU/ZMYND10 can functionally suppress tumor formation in vivo and is, therefore, likely to be one of the candidate tumor suppressor genes involved in NPC.
Persistent Identifierhttp://hdl.handle.net/10722/150805
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWing, LYen_US
dc.contributor.authorHong, LLen_US
dc.contributor.authorZabarovsky, ERen_US
dc.contributor.authorLerman, MIen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorChua, DTTen_US
dc.contributor.authorSai, WTen_US
dc.contributor.authorStanbridge, EJen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:10:47Z-
dc.date.available2012-06-26T06:10:47Z-
dc.date.issued2006en_US
dc.identifier.citationInternational Journal Of Cancer, 2006, v. 119 n. 12, p. 2821-2826en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://hdl.handle.net/10722/150805-
dc.description.abstractChromosome 3p plays an important role in tumorigenesis in many cancers, including nasopharyngeal carcinoma (NPC). We have previously shown chromosome 3p can suppress tumor growth in vivo by using the monochromosome transfer approach, which indicated the chromosome 3p21.3 region was critical for tumor suppression. BLU/ZMYND10 is one of the candidate tumor suppressor genes mapping in the 3p21.3 critical region and is a candidate TSG for NPC. By quantitative RT-PCR, it is frequently downregulated in NPC cell lines (83%) and NPC biopsies (80%). However, no functional studies have yet verified the functional role of BLU/ZMYND10 as a tumor suppressor gene. In the current study, a gene inactivation test (GIT) utilizing a tetracycline regulation system was used to study the functional role of BLU/ZMYND10. When BLU/ZMYND10 is expressed in the absence of doxycycline, the stable transfectants were able to induce tumor suppression in nude mice. In contrast, downregulation of BLU/ZMYND10 in these tumor suppressive clones by doxycycline treatment restored the tumor formation ability. This study provides the first significant evidence to demonstrate BLU/ZMYND10 can functionally suppress tumor formation in vivo and is, therefore, likely to be one of the candidate tumor suppressor genes involved in NPC.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_US
dc.relation.ispartofInternational Journal of Canceren_US
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectBLU/ZMYND10-
dc.subjectChromosome 3p21.3-
dc.subjectNasopharyngeal carcinoma-
dc.subjectTumor suppressor gene-
dc.subject.meshAnimalsen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshChromosomes, Human, Pair 3 - Geneticsen_US
dc.subject.meshDown-Regulation - Drug Effects - Geneticsen_US
dc.subject.meshDoxycycline - Pharmacology - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplastic - Geneticsen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshNasopharyngeal Neoplasms - Drug Therapy - Genetics - Pathologyen_US
dc.subject.meshTransfectionen_US
dc.subject.meshTumor Suppressor Proteins - Geneticsen_US
dc.subject.meshXenograft Model Antitumor Assays - Methodsen_US
dc.titleFunctional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailHong, LL:hllung2@hku.hken_US
dc.identifier.emailChua, DTT:dttchua@hkucc.hku.hken_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityHong, LL=rp00299en_US
dc.identifier.authorityChua, DTT=rp00415en_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ijc.22232en_US
dc.identifier.pmid16929489-
dc.identifier.scopuseid_2-s2.0-33751561140en_US
dc.identifier.hkuros138253-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33751561140&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume119en_US
dc.identifier.issue12en_US
dc.identifier.spage2821en_US
dc.identifier.epage2826en_US
dc.identifier.isiWOS:000242307800013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWing, LY=15119281300en_US
dc.identifier.scopusauthoridHong, LL=6603819904en_US
dc.identifier.scopusauthoridZabarovsky, ER=7007009108en_US
dc.identifier.scopusauthoridLerman, MI=24356375900en_US
dc.identifier.scopusauthoridSham, JST=24472255400en_US
dc.identifier.scopusauthoridChua, DTT=7006773480en_US
dc.identifier.scopusauthoridSai, WT=6507617572en_US
dc.identifier.scopusauthoridStanbridge, EJ=7103249410en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US

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