File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trial

TitleXerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trial
Authors
KeywordsNasopharyngeal carcinoma
Parotid sparing
Quality of life
Radiotherapy
Randomized controlled clinical trial
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal of Radiation Oncology - Biology - Physics, 2006, v. 66 n. 4, p. 981-991 How to Cite?
AbstractPurpose: To compare directly the effect of intensity-modulated radiotherapy (IMRT) vs. conventional radiotherapy (CRT) on salivary flow and quality of life (QoL) in patients with early-stage nasopharyngeal carcinoma (NPC). Methods and Materials: Fifty-one patients with T2, N0/N1, M0 NPC took part in a randomized controlled clinical study and received IMRT or CRT. Stimulated whole (SWS) and parotid (SPS) saliva flow were measured and Medical Outcomes Short Form 36 (SF-36), European Organization for Research and Treatment of Cancer (EORTC) core quetionnaire, and EORTC head-and-neck module (QLQ-H&N35) were completed at baseline and 2, 6, and 12 months after radiotherapy. Results: Forty-six patients (88%) were in disease remission 12 months after radiotherapy. At 12 months postradiotherapy, 12 (50.0%) and 20 patients (83.3%) in the IMRT group had recovered at least 25% of preradiotherapy SWS and SPS flow respectively, compared with 1 (4.8%) and 2 patients (9.5%), respectively, in the CRT group. Global health scores showed continuous improvement in QoL after both treatments (p < 0.001). However, after 12 months subscale scores for role-physical, bodily pain, and physical function were significantly higher in the IMRT group, indicating a better condition (p < 0.05). Dry mouth and sticky saliva were problems in both groups 2 months after treatment. In the IMRT group, there was consistent improvement over time with xerostomia-related symptoms significantly less common than in the CRT group at 12 months postradiotherapy. Conclusions: IMRT was significantly better than CRT in terms of parotid sparing and improved QoL for early-stage disease. The findings support the case for assessment of health-related QoL in relation to head-and-neck cancer using a site-specific approach. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150804
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPow, EHNen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorMcMillan, ASen_HK
dc.contributor.authorWong, MCMen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorLeung, WKen_HK
dc.date.accessioned2012-06-26T06:10:46Z-
dc.date.available2012-06-26T06:10:46Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 2006, v. 66 n. 4, p. 981-991en_HK
dc.identifier.issn0360-3016en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150804-
dc.description.abstractPurpose: To compare directly the effect of intensity-modulated radiotherapy (IMRT) vs. conventional radiotherapy (CRT) on salivary flow and quality of life (QoL) in patients with early-stage nasopharyngeal carcinoma (NPC). Methods and Materials: Fifty-one patients with T2, N0/N1, M0 NPC took part in a randomized controlled clinical study and received IMRT or CRT. Stimulated whole (SWS) and parotid (SPS) saliva flow were measured and Medical Outcomes Short Form 36 (SF-36), European Organization for Research and Treatment of Cancer (EORTC) core quetionnaire, and EORTC head-and-neck module (QLQ-H&N35) were completed at baseline and 2, 6, and 12 months after radiotherapy. Results: Forty-six patients (88%) were in disease remission 12 months after radiotherapy. At 12 months postradiotherapy, 12 (50.0%) and 20 patients (83.3%) in the IMRT group had recovered at least 25% of preradiotherapy SWS and SPS flow respectively, compared with 1 (4.8%) and 2 patients (9.5%), respectively, in the CRT group. Global health scores showed continuous improvement in QoL after both treatments (p < 0.001). However, after 12 months subscale scores for role-physical, bodily pain, and physical function were significantly higher in the IMRT group, indicating a better condition (p < 0.05). Dry mouth and sticky saliva were problems in both groups 2 months after treatment. In the IMRT group, there was consistent improvement over time with xerostomia-related symptoms significantly less common than in the CRT group at 12 months postradiotherapy. Conclusions: IMRT was significantly better than CRT in terms of parotid sparing and improved QoL for early-stage disease. The findings support the case for assessment of health-related QoL in relation to head-and-neck cancer using a site-specific approach. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobpen_HK
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_HK
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.-
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectParotid sparingen_HK
dc.subjectQuality of lifeen_HK
dc.subjectRadiotherapyen_HK
dc.subjectRandomized controlled clinical trialen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Complications - Radiotherapyen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshQuality Of Lifeen_US
dc.subject.meshRadiation Injuries - Etiology - Prevention & Controlen_US
dc.subject.meshRadiotherapy, Conformal - Adverse Effectsen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshXerostomia - Etiology - Prevention & Controlen_US
dc.titleXerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trialen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0360-3016&volume=66&spage=981&epage=991&date=2006&atitle=Xerostomia+and+quality+of+life+after+intensity-modulated+radiotherapy+vs.+conventional+radiotherapy+for+early-stage+nasopharyngeal+carcinoma:+Initial+report+on+a+randomized+control+clinical+trial.-
dc.identifier.emailPow, EHN: ehnpow@hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.emailMcMillan, AS: annemcmillan@hku.hken_HK
dc.identifier.emailWong, MCM: mcmwong@hkucc.hku.hken_HK
dc.identifier.emailSham, JST: jstsham@hku.hken_HK
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hk-
dc.identifier.authorityPow, EHN=rp00030en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityMcMillan, AS=rp00014en_HK
dc.identifier.authorityWong, MCM=rp00024en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijrobp.2006.06.013en_HK
dc.identifier.pmid17145528-
dc.identifier.scopuseid_2-s2.0-33750357039en_HK
dc.identifier.hkuros124843-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750357039&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume66en_HK
dc.identifier.issue4en_HK
dc.identifier.spage981en_HK
dc.identifier.epage991en_HK
dc.identifier.isiWOS:000241598600004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPow, EHN=6603825799en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridMcMillan, AS=7102843317en_HK
dc.identifier.scopusauthoridWong, MCM=26029250900en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridLeung, LHT=7202048113en_HK
dc.identifier.scopusauthoridLeung, WK=25224691800en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats