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Article: Establishment and characterization of a human non-small cell lung cancer cell line.

TitleEstablishment and characterization of a human non-small cell lung cancer cell line.
Authors
Issue Date2005
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 2005, v. 13 n. 6, p. 1029-1032 How to Cite?
AbstractLung cancer is one of the most common causes of cancer death worldwide. Although many efforts have been made to explore the mechanisms involved in the development of lung cancer, the genetic events involved in the pathogenesis of lung cancer are still unclear. For a better mechanistic scope of study, a well-established cellular model is essential. We report the establishment of a squamous cell carcinoma (SCC) cell line of human lung, SCC-37. Chromosomal abnormalities and global genomic alterations of SCC-37 were studied by spectral karyotyping (SKY) and comparative genomic hybridization (CGH), respectively. Results showed that SCC-37 was a hypodiploid with complex chromosomal rearrangements. Some of the alterations, such as the gain of 1q25-qter in SCC-37, have been correlated to the tumor recurrence of non-small cell lung cancer (NSCLC). Other interesting findings include the amplification of 3q25-qter and 12q13, suggesting the existence of important oncogenes in the amplicons. This cell line may thus provide a useful cellular resource for studying the pathogenesis of SCC of the lung in the future.
Persistent Identifierhttp://hdl.handle.net/10722/150796
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTai, ALen_HK
dc.contributor.authorFang, Yen_HK
dc.contributor.authorSham, JSen_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorHu, Len_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorTsao, GSen_HK
dc.contributor.authorCheung, ALen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2012-06-26T06:10:38Z-
dc.date.available2012-06-26T06:10:38Z-
dc.date.issued2005en_HK
dc.identifier.citationOncology Reports, 2005, v. 13 n. 6, p. 1029-1032en_HK
dc.identifier.issn1021-335Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/150796-
dc.description.abstractLung cancer is one of the most common causes of cancer death worldwide. Although many efforts have been made to explore the mechanisms involved in the development of lung cancer, the genetic events involved in the pathogenesis of lung cancer are still unclear. For a better mechanistic scope of study, a well-established cellular model is essential. We report the establishment of a squamous cell carcinoma (SCC) cell line of human lung, SCC-37. Chromosomal abnormalities and global genomic alterations of SCC-37 were studied by spectral karyotyping (SKY) and comparative genomic hybridization (CGH), respectively. Results showed that SCC-37 was a hypodiploid with complex chromosomal rearrangements. Some of the alterations, such as the gain of 1q25-qter in SCC-37, have been correlated to the tumor recurrence of non-small cell lung cancer (NSCLC). Other interesting findings include the amplification of 3q25-qter and 12q13, suggesting the existence of important oncogenes in the amplicons. This cell line may thus provide a useful cellular resource for studying the pathogenesis of SCC of the lung in the future.en_HK
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_HK
dc.relation.ispartofOncology reportsen_HK
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Enzymology - Genetics - Pathologyen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosomes, Human, Pair 12 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 3 - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshLung Neoplasms - Enzymology - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshSpectral Karyotypingen_US
dc.subject.meshTelomerase - Metabolismen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleEstablishment and characterization of a human non-small cell lung cancer cell line.en_HK
dc.typeArticleen_HK
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_HK
dc.identifier.emailTsao, GS: gswtsao@hku.hken_HK
dc.identifier.emailCheung, AL: lmcheung@hku.hken_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.authorityDeng, W=rp01640en_HK
dc.identifier.authorityTsao, GS=rp00399en_HK
dc.identifier.authorityCheung, AL=rp00332en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15870917-
dc.identifier.scopuseid_2-s2.0-24744438297en_HK
dc.identifier.hkuros115337-
dc.identifier.volume13en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1029en_HK
dc.identifier.epage1032en_HK
dc.identifier.isiWOS:000229057300004-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridTai, AL=8234187900en_HK
dc.identifier.scopusauthoridFang, Y=7403457405en_HK
dc.identifier.scopusauthoridSham, JS=24472255400en_HK
dc.identifier.scopusauthoridDeng, W=7202223673en_HK
dc.identifier.scopusauthoridHu, L=25958137600en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridTsao, GS=7102813116en_HK
dc.identifier.scopusauthoridCheung, AL=7401806497en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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