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Article: Comparative genomic hybridization for the profile of chromosomal imbalances in cardia adenocarcinoma and metastatic lymph node lesions

TitleComparative genomic hybridization for the profile of chromosomal imbalances in cardia adenocarcinoma and metastatic lymph node lesions
Authors
KeywordsCgh
Gca
Lymph Node Metastasis
Issue Date2005
Publisher中國中西醫結合學會. The Journal's web site is located at http://xxhb.chinajournal.net.cn/
Citation
World Chinese Journal Of Digestology, 2005, v. 13 n. 1, p. 15-19 How to Cite?
AbstractAIM: To profile the chromosomal imbalances in gastric cardia adenocarcinoma (GCA) and the metastatic lymph node (LN) lesions from the high incidence area of esophageal squamous cell carcinoma/GCA in Henan province, and to provide the molecular basis for identifying the related genes for GCA and GCA lymph nodes metastasis. METHODS: Chromosomal imbalances were studied in 30 GCA resection specimens and 7 metastatic LN lesions by comparative genomic hybridization (CGH). RESULTS: In 30 GCA specimens, a total of 126 gains and 117 losses were found, and the average gain and loss was 4.2 and 3.9, respectively. The chromosomal gain most frequently identified in GCA was on 20q (43%), and others were on 6q (40%), 8q (37%), 6p (33%), 7q (33%), 1q (30%), 7p (27%), 13q (23%), 11q (20%) and 5p (20%) respectively. Losses were observed predominantly on 17p (57%), 19q (50%), 1p (47%), 3p (30%) and 4p (20%). In 7 LN lesions, a total of 75 gains and 58 losses were found, and the average gain and loss were 10.7 and 8.3, respectively. Gains were detected on chromosome 8q (5/ 7), 20 (4/7) and 1q, 2p, 3q, 6, 7, 11p11-q13, 11q14-q23, 13 (3/7 each), and deletions on chromosome 9p13-qter (4/7), 4 (3/7) and 1pter-1q33, 7p12-qter, 16p, 17p, 18 (2/7 each). CONCLUSION: The gains of 20q, 6q, 8q, 7p, 6p, 7q, 1q, 13q, 11q, 5p and losses of 17p, 19q, 1p, 3p, 4p are specifically implicated in GCA, and gains of 8q, 20q and losses of 9p, 4pq may be associated with lymph node metastasis.
Persistent Identifierhttp://hdl.handle.net/10722/150789
ISSN
2015 SCImago Journal Rankings: 0.104
References

 

DC FieldValueLanguage
dc.contributor.authorQin, YRen_US
dc.contributor.authorWang, LDen_US
dc.contributor.authorKwong, Den_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorZhuang, ZHen_US
dc.date.accessioned2012-06-26T06:10:31Z-
dc.date.available2012-06-26T06:10:31Z-
dc.date.issued2005en_US
dc.identifier.citationWorld Chinese Journal Of Digestology, 2005, v. 13 n. 1, p. 15-19en_US
dc.identifier.issn1009-3079en_US
dc.identifier.urihttp://hdl.handle.net/10722/150789-
dc.description.abstractAIM: To profile the chromosomal imbalances in gastric cardia adenocarcinoma (GCA) and the metastatic lymph node (LN) lesions from the high incidence area of esophageal squamous cell carcinoma/GCA in Henan province, and to provide the molecular basis for identifying the related genes for GCA and GCA lymph nodes metastasis. METHODS: Chromosomal imbalances were studied in 30 GCA resection specimens and 7 metastatic LN lesions by comparative genomic hybridization (CGH). RESULTS: In 30 GCA specimens, a total of 126 gains and 117 losses were found, and the average gain and loss was 4.2 and 3.9, respectively. The chromosomal gain most frequently identified in GCA was on 20q (43%), and others were on 6q (40%), 8q (37%), 6p (33%), 7q (33%), 1q (30%), 7p (27%), 13q (23%), 11q (20%) and 5p (20%) respectively. Losses were observed predominantly on 17p (57%), 19q (50%), 1p (47%), 3p (30%) and 4p (20%). In 7 LN lesions, a total of 75 gains and 58 losses were found, and the average gain and loss were 10.7 and 8.3, respectively. Gains were detected on chromosome 8q (5/ 7), 20 (4/7) and 1q, 2p, 3q, 6, 7, 11p11-q13, 11q14-q23, 13 (3/7 each), and deletions on chromosome 9p13-qter (4/7), 4 (3/7) and 1pter-1q33, 7p12-qter, 16p, 17p, 18 (2/7 each). CONCLUSION: The gains of 20q, 6q, 8q, 7p, 6p, 7q, 1q, 13q, 11q, 5p and losses of 17p, 19q, 1p, 3p, 4p are specifically implicated in GCA, and gains of 8q, 20q and losses of 9p, 4pq may be associated with lymph node metastasis.en_US
dc.languageengen_US
dc.publisher中國中西醫結合學會. The Journal's web site is located at http://xxhb.chinajournal.net.cn/zh_HK
dc.relation.ispartofWorld Chinese Journal of Digestologyen_US
dc.subjectCghen_US
dc.subjectGcaen_US
dc.subjectLymph Node Metastasisen_US
dc.titleComparative genomic hybridization for the profile of chromosomal imbalances in cardia adenocarcinoma and metastatic lymph node lesionsen_US
dc.typeArticleen_US
dc.identifier.emailKwong, D:dlwkwong@hku.hken_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityKwong, D=rp00414en_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-15944425399en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-15944425399&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.spage15en_US
dc.identifier.epage19en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridQin, YR=7403100680en_US
dc.identifier.scopusauthoridWang, LD=12242861000en_US
dc.identifier.scopusauthoridKwong, D=15744231600en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridZhuang, ZH=7203003327en_US

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