File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer

TitleCharacterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer
Authors
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcpr
Citation
Molecular And Cellular Probes, 2004, v. 18 n. 1, p. 39-44 How to Cite?
AbstractThe FUS2 gene, encoding a novel cytoplasmic acetyltransferase, resides in the tumor suppressor gene region on human chromosome 3p21.3 and is considered a promising candidate tumor suppressor gene. We have identified a new single nucleotide polymorphism (SNP), c767A/T, in the coding region of the gene. The polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase (GNAT) and the proline-rich domains of the protein. We have analyzed 254 subjects included in 14 sub-populations. The occurrence of the SNP varies with the ethnicity of the population, suggesting that this SNP could be a valuable biomarker for population genetics. It is most prevalent in various Asian populations (T allele frequency>0.54), followed by the Canadian polar Inuit (T allele frequency=0.3), African American (T allele frequency=0.17), and Caucasian population (T allele frequency=0.1). Since nasopharyngeal carcinoma (NPC) is frequent in Southern China, Taiwan, Borneo and polar Canada, we further tested for the possible association of the FUS2 SNP with this form of endemic cancer. Our analysis, albeit limited, suggests no likely association between NPC and the FUS2 gene polymorphism. Further large-scale case-control studies are necessary and warranted to prove the strength of this contention. © 2003 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150788
ISSN
2015 Impact Factor: 1.565
2015 SCImago Journal Rankings: 0.610
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDuh, FMen_US
dc.contributor.authorFivash, Men_US
dc.contributor.authorMoody, Men_US
dc.contributor.authorLi Lung, Men_US
dc.contributor.authorGuo, Xen_US
dc.contributor.authorStanbridge, Een_US
dc.contributor.authorDean, Men_US
dc.contributor.authorVoevoda, Men_US
dc.contributor.authorHu, LFen_US
dc.contributor.authorKashuba, Ven_US
dc.contributor.authorZabarovsky, ERen_US
dc.contributor.authorQian, CNen_US
dc.contributor.authorGodbole, Sen_US
dc.contributor.authorTean Teh, Ben_US
dc.contributor.authorLerman, MIen_US
dc.date.accessioned2012-06-26T06:10:31Z-
dc.date.available2012-06-26T06:10:31Z-
dc.date.issued2004en_US
dc.identifier.citationMolecular And Cellular Probes, 2004, v. 18 n. 1, p. 39-44en_US
dc.identifier.issn0890-8508en_US
dc.identifier.urihttp://hdl.handle.net/10722/150788-
dc.description.abstractThe FUS2 gene, encoding a novel cytoplasmic acetyltransferase, resides in the tumor suppressor gene region on human chromosome 3p21.3 and is considered a promising candidate tumor suppressor gene. We have identified a new single nucleotide polymorphism (SNP), c767A/T, in the coding region of the gene. The polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase (GNAT) and the proline-rich domains of the protein. We have analyzed 254 subjects included in 14 sub-populations. The occurrence of the SNP varies with the ethnicity of the population, suggesting that this SNP could be a valuable biomarker for population genetics. It is most prevalent in various Asian populations (T allele frequency>0.54), followed by the Canadian polar Inuit (T allele frequency=0.3), African American (T allele frequency=0.17), and Caucasian population (T allele frequency=0.1). Since nasopharyngeal carcinoma (NPC) is frequent in Southern China, Taiwan, Borneo and polar Canada, we further tested for the possible association of the FUS2 SNP with this form of endemic cancer. Our analysis, albeit limited, suggests no likely association between NPC and the FUS2 gene polymorphism. Further large-scale case-control studies are necessary and warranted to prove the strength of this contention. © 2003 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcpren_US
dc.relation.ispartofMolecular and Cellular Probesen_US
dc.subject.meshAcetyltransferases - Genetics - Physiologyen_US
dc.subject.meshAsia - Epidemiology - Ethnologyen_US
dc.subject.meshChromosomes, Human, Pair 3en_US
dc.subject.meshEndemic Diseasesen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshHumansen_US
dc.subject.meshNasopharyngeal Neoplasms - Ethnology - Geneticsen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProtein Structure, Tertiaryen_US
dc.titleCharacterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal canceren_US
dc.typeArticleen_US
dc.identifier.emailLi Lung, M:mlilung@hku.hken_US
dc.identifier.authorityLi Lung, M=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.mcp.2003.09.002en_US
dc.identifier.pmid15036368-
dc.identifier.scopuseid_2-s2.0-10744221645en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10744221645&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue1en_US
dc.identifier.spage39en_US
dc.identifier.epage44en_US
dc.identifier.isiWOS:000220161300005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridDuh, FM=7004146642en_US
dc.identifier.scopusauthoridFivash, M=6602274551en_US
dc.identifier.scopusauthoridMoody, M=7102854896en_US
dc.identifier.scopusauthoridLi Lung, M=7006411788en_US
dc.identifier.scopusauthoridGuo, X=8921135000en_US
dc.identifier.scopusauthoridStanbridge, E=7103249410en_US
dc.identifier.scopusauthoridDean, M=35374417600en_US
dc.identifier.scopusauthoridVoevoda, M=7004003785en_US
dc.identifier.scopusauthoridHu, LF=25958137600en_US
dc.identifier.scopusauthoridKashuba, V=34770221200en_US
dc.identifier.scopusauthoridZabarovsky, ER=7007009108en_US
dc.identifier.scopusauthoridQian, CN=7202311133en_US
dc.identifier.scopusauthoridGodbole, S=54889272600en_US
dc.identifier.scopusauthoridTean Teh, B=6504086517en_US
dc.identifier.scopusauthoridLerman, MI=24356375900en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats