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Article: Comparative genomic hybridization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high-incidence region of esophageal carcinoma, Linzhou Henan

TitleComparative genomic hybridization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high-incidence region of esophageal carcinoma, Linzhou Henan
Authors
Issue Date2004
Citation
Chinese Journal Of Medical Genetics, 2004, v. 21 n. 6, p. 625-628 How to Cite?
AbstractObjective: To characterize the profiles of chromosome imbalance in esophagaeal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA) from the high incidence area in Henan. Methods: Chromosomal aberrations of 37 samples of SCC and 30 GCA were analyzed by comparative genomic hybridization comparative genomic hybridization (CGH). Results: It was found that the most frequently detected gains were on chromosome arm 8q (78%), and followed by 3q, 5p, 6q and 7p. The most frequent loss was found on 3p (57%), and followed by 8p, 9q and 11q in SCC. For GCA, the most frequent gain was found on chromosome arm 20q (43%), and followed by 6q, 8q and 6p. The most frequent loss was on the chromosome 17p (57%), and followed by 19p, lp and 4p. Conclusion: The present findings demonstrate that gains of 8q, 3q and 5p, and losses of 3p, 8p, and 9q are characteristic profile of chromosome imbalance in SCC, and the gains of 20q, 6q and losses of 17p, 19p and 1p are characteristic profile of chromosome imbalance in GCA, which provide important theoretic information for identifying and cloning novel SCC/GCA-related genes.
Persistent Identifierhttp://hdl.handle.net/10722/150787
ISSN
2015 SCImago Journal Rankings: 0.187
References

 

DC FieldValueLanguage
dc.contributor.authorQin, YRen_US
dc.contributor.authorWang, LDen_US
dc.contributor.authorKwong, Den_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorZhuang, ZHen_US
dc.contributor.authorFan, ZMen_US
dc.contributor.authorAn, JYen_US
dc.contributor.authorTsao, Gen_US
dc.date.accessioned2012-06-26T06:10:30Z-
dc.date.available2012-06-26T06:10:30Z-
dc.date.issued2004en_US
dc.identifier.citationChinese Journal Of Medical Genetics, 2004, v. 21 n. 6, p. 625-628en_US
dc.identifier.issn1003-9406en_US
dc.identifier.urihttp://hdl.handle.net/10722/150787-
dc.description.abstractObjective: To characterize the profiles of chromosome imbalance in esophagaeal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA) from the high incidence area in Henan. Methods: Chromosomal aberrations of 37 samples of SCC and 30 GCA were analyzed by comparative genomic hybridization comparative genomic hybridization (CGH). Results: It was found that the most frequently detected gains were on chromosome arm 8q (78%), and followed by 3q, 5p, 6q and 7p. The most frequent loss was found on 3p (57%), and followed by 8p, 9q and 11q in SCC. For GCA, the most frequent gain was found on chromosome arm 20q (43%), and followed by 6q, 8q and 6p. The most frequent loss was on the chromosome 17p (57%), and followed by 19p, lp and 4p. Conclusion: The present findings demonstrate that gains of 8q, 3q and 5p, and losses of 3p, 8p, and 9q are characteristic profile of chromosome imbalance in SCC, and the gains of 20q, 6q and losses of 17p, 19p and 1p are characteristic profile of chromosome imbalance in GCA, which provide important theoretic information for identifying and cloning novel SCC/GCA-related genes.en_US
dc.languageengen_US
dc.relation.ispartofChinese Journal of Medical Geneticsen_US
dc.subject.meshAdenocarcinoma - Geneticsen_US
dc.subject.meshCarcinoma, Squamous Cell - Epidemiology - Geneticsen_US
dc.subject.meshCardiaen_US
dc.subject.meshChromosomes, Human, Pair 17en_US
dc.subject.meshChromosomes, Human, Pair 20en_US
dc.subject.meshChromosomes, Human, Pair 3en_US
dc.subject.meshChromosomes, Human, Pair 8en_US
dc.subject.meshDna, Neoplasm - Geneticsen_US
dc.subject.meshEsophageal Neoplasms - Epidemiology - Geneticsen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHumansen_US
dc.subject.meshNucleic Acid Hybridization - Methodsen_US
dc.subject.meshStomach Neoplasms - Epidemiology - Geneticsen_US
dc.titleComparative genomic hybridization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high-incidence region of esophageal carcinoma, Linzhou Henanen_US
dc.typeArticleen_US
dc.identifier.emailKwong, D:dlwkwong@hku.hken_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.emailTsao, G:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityKwong, D=rp00414en_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.identifier.authorityTsao, G=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15583998-
dc.identifier.scopuseid_2-s2.0-10644278963en_US
dc.identifier.hkuros101396-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10644278963&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issue6en_US
dc.identifier.spage625en_US
dc.identifier.epage628en_US
dc.identifier.scopusauthoridQin, YR=7403100680en_US
dc.identifier.scopusauthoridWang, LD=12242861000en_US
dc.identifier.scopusauthoridKwong, D=15744231600en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridZhuang, ZH=7203003327en_US
dc.identifier.scopusauthoridFan, ZM=7402099547en_US
dc.identifier.scopusauthoridAn, JY=22953119200en_US
dc.identifier.scopusauthoridTsao, G=7102813116en_US

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