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Article: Diffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: A pilot study

TitleDiffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: A pilot study
Authors
Issue Date2003
PublisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org
Citation
American Journal Of Neuroradiology, 2003, v. 24 n. 4, p. 734-740 How to Cite?
AbstractBACKGROUND AND PURPOSE: Treatment-induced white matter (WM) injury in medulloblastoma survivors, as manifested by deterioration of cognitive function, is prevalent. However, no reliable imaging method exists for early detection and quantification. Our goal was to determine whether anisotropy of WM is reduced in medulloblastoma survivors and whether fractional anisotropy (FA) can be used as an index for evaluation of treatment-induced WM injury. METHODS: We evaluated nine medulloblastoma survivors treated with surgery, cranial irradiation, and chemotherapy by use of diffusion-tensor (DT) imaging and compared FA findings in selected WM sites (cerebellar hemispheres, pons, medulla oblongata, frontal periventricular WM, parietal periventricular WM, and corona radiata) with those of healthy age-matched control subjects. FA maps were compared with conventional T2-weighted images. FA was also compared with age at treatment, time interval since treatment, and deterioration of school performance. The two-tailed paired t test was used to determine statistical significance (P < .05). RESULTS: Significant reduction of FA (P < .05) was seen in all anatomic sites in the patient group compared with FA in control subjects, except in the frontal periventricular WM, even in areas with normal appearance on T2-weighted images. FA reduction ranged from 12.4-19% (mean, 16.5%). Compared with control subjects, posterior fossa and supratentorial WM FA in patients were reduced by 14.6% (SD 1.9%) and 18.4% (SD 0.55%), respectively (P = .029). Reduction of supratentorial WM FA correlated with younger age at treatment (< 5 years), longer interval since treatment (> 5 years), and deterioration of school performance. CONCLUSION: DT imaging and use of the index FA is potentially useful for early detection and monitoring of treatment-induced WM injury in children with medulloblastoma.
Persistent Identifierhttp://hdl.handle.net/10722/150782
ISSN
2015 Impact Factor: 3.124
2015 SCImago Journal Rankings: 1.602
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKhong, PLen_US
dc.contributor.authorKwong, DLWen_US
dc.contributor.authorChan, GCFen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorChan, FLen_US
dc.contributor.authorOoi, GCen_US
dc.date.accessioned2012-06-26T06:10:25Z-
dc.date.available2012-06-26T06:10:25Z-
dc.date.issued2003en_US
dc.identifier.citationAmerican Journal Of Neuroradiology, 2003, v. 24 n. 4, p. 734-740en_US
dc.identifier.issn0195-6108en_US
dc.identifier.urihttp://hdl.handle.net/10722/150782-
dc.description.abstractBACKGROUND AND PURPOSE: Treatment-induced white matter (WM) injury in medulloblastoma survivors, as manifested by deterioration of cognitive function, is prevalent. However, no reliable imaging method exists for early detection and quantification. Our goal was to determine whether anisotropy of WM is reduced in medulloblastoma survivors and whether fractional anisotropy (FA) can be used as an index for evaluation of treatment-induced WM injury. METHODS: We evaluated nine medulloblastoma survivors treated with surgery, cranial irradiation, and chemotherapy by use of diffusion-tensor (DT) imaging and compared FA findings in selected WM sites (cerebellar hemispheres, pons, medulla oblongata, frontal periventricular WM, parietal periventricular WM, and corona radiata) with those of healthy age-matched control subjects. FA maps were compared with conventional T2-weighted images. FA was also compared with age at treatment, time interval since treatment, and deterioration of school performance. The two-tailed paired t test was used to determine statistical significance (P < .05). RESULTS: Significant reduction of FA (P < .05) was seen in all anatomic sites in the patient group compared with FA in control subjects, except in the frontal periventricular WM, even in areas with normal appearance on T2-weighted images. FA reduction ranged from 12.4-19% (mean, 16.5%). Compared with control subjects, posterior fossa and supratentorial WM FA in patients were reduced by 14.6% (SD 1.9%) and 18.4% (SD 0.55%), respectively (P = .029). Reduction of supratentorial WM FA correlated with younger age at treatment (< 5 years), longer interval since treatment (> 5 years), and deterioration of school performance. CONCLUSION: DT imaging and use of the index FA is potentially useful for early detection and monitoring of treatment-induced WM injury in children with medulloblastoma.en_US
dc.languageengen_US
dc.publisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.orgen_US
dc.relation.ispartofAmerican Journal of Neuroradiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAnisotropyen_US
dc.subject.meshBrain - Pathologyen_US
dc.subject.meshBrain Damage, Chronic - Diagnosis - Etiologyen_US
dc.subject.meshCerebellar Neoplasms - Therapyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCognition Disorders - Diagnosis - Etiologyen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshDiffusion Magnetic Resonance Imagingen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Enhancementen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshLearning Disorders - Diagnosis - Etiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMedulloblastoma - Therapyen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSurvivorsen_US
dc.titleDiffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: A pilot studyen_US
dc.typeArticleen_US
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_US
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_US
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_US
dc.identifier.authorityKhong, PL=rp00467en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid12695214-
dc.identifier.scopuseid_2-s2.0-0347078302en_US
dc.identifier.hkuros81003-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347078302&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue4en_US
dc.identifier.spage734en_US
dc.identifier.epage740en_US
dc.identifier.isiWOS:000182422900037-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKhong, PL=7006693233en_US
dc.identifier.scopusauthoridKwong, DLW=15744231600en_US
dc.identifier.scopusauthoridChan, GCF=16160154400en_US
dc.identifier.scopusauthoridSham, JST=24472255400en_US
dc.identifier.scopusauthoridChan, FL=7202586444en_US
dc.identifier.scopusauthoridOoi, GC=16239781100en_US

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