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Article: Frequent loss of heterozygosity on chromosome 9 in Chinese esophageal squamous cell carcinomas

TitleFrequent loss of heterozygosity on chromosome 9 in Chinese esophageal squamous cell carcinomas
Authors
Lichun, YTang, CMCWai Lau, KLung, ML
KeywordsChinese
Chromosome 9
Esophageal carcinoma
Loss of heterozygosity
Microsatellite instability
Tumor suppressor gene
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2004, v. 203 n. 1, p. 71-77 How to Cite?
DOI: http://dx.doi.org/10.1016/j.canlet.2003.09.027
AbstractMultiple and extensive alterations in chromosome 9 were detected in thirty-four esophageal squamous cell carcinoma patients, using seventeen polymorphic markers localized to chromosome 9 to detect the loss of heterozygosity (LOH) by polymerase chain reaction techniques. The LOH rates detected in this study range from 42.9 to 80.0%. Three commonly deleted regions mapping to 9p23-p22, 9q13-q22.3, and 9q34 were observed. D9S1812 LOH at 9q22.1 was significantly associated with well- and moderately-differentiated tumors; LOH at D9S768, mapping to 9q13-21.3, indicated that drinking habits are not a significant risk factor for Chinese esophagus cancer. Interestingly, no case of microsatellite instability was observed. © 2004 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150780
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
ISI Accession Number ID
WOS:000187858100008
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLichun, Yen_US
dc.contributor.authorTang, CMCen_US
dc.contributor.authorWai Lau, Ken_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:10:23Z-
dc.date.available2012-06-26T06:10:23Z-
dc.date.issued2004en_US
dc.identifier.citationCancer Letters, 2004, v. 203 n. 1, p. 71-77en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/150780-
dc.description.abstractMultiple and extensive alterations in chromosome 9 were detected in thirty-four esophageal squamous cell carcinoma patients, using seventeen polymorphic markers localized to chromosome 9 to detect the loss of heterozygosity (LOH) by polymerase chain reaction techniques. The LOH rates detected in this study range from 42.9 to 80.0%. Three commonly deleted regions mapping to 9p23-p22, 9q13-q22.3, and 9q34 were observed. D9S1812 LOH at 9q22.1 was significantly associated with well- and moderately-differentiated tumors; LOH at D9S768, mapping to 9q13-21.3, indicated that drinking habits are not a significant risk factor for Chinese esophagus cancer. Interestingly, no case of microsatellite instability was observed. © 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subjectChinese-
dc.subjectChromosome 9-
dc.subjectEsophageal carcinoma-
dc.subjectLoss of heterozygosity-
dc.subjectMicrosatellite instability-
dc.subjectTumor suppressor gene-
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 9en_US
dc.subject.meshEsophageal Neoplasms - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLoss Of Heterozygosityen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosatellite Repeatsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.titleFrequent loss of heterozygosity on chromosome 9 in Chinese esophageal squamous cell carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.canlet.2003.09.027en_US
dc.identifier.pmid14670619-
dc.identifier.scopuseid_2-s2.0-0344304770en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344304770&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume203en_US
dc.identifier.issue1en_US
dc.identifier.spage71en_US
dc.identifier.epage77en_US
dc.identifier.isiWOS:000187858100008-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridLichun, Y=6505477708en_US
dc.identifier.scopusauthoridTang, CMC=8274797200en_US
dc.identifier.scopusauthoridWai Lau, K=6504789324en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.issnl0304-3835-

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