Article: Genetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas

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TitleGenetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas
AuthorsKwong, FM1
Wong, PS1
Lung, ML1
Issue Date2003
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
CitationCancer Letters, 2003, v. 192 n. 2, p. 189-198 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0304-3835(02)00698-5
AbstractGenetic alterations in 28 non-small cell lung carcinoma patients were detected on chromosomes 13q and 14q with microsatellite markers by polymerase chain reaction techniques. Loss of heterozygosity of up to 50% was detected with chromosome 13 markers and of up to 37% for chromosome 14. Microsatellite instability was as high as 30% on chromosome 13 and up to 19% on chromosome 14. Accumulated mutation frequencies of up to 94 and 93% were observed for chromosomes 13 and 14, respectively. Of eight tumors displaying high mutation frequencies, 1 also carried a K-ras mutation and 4 had p53 mutations. A significant association was observed between p53 mutations and genetic instability. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
ISSN0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
DOIhttp://dx.doi.org/10.1016/S0304-3835(02)00698-5
ISI Accession Number IDWOS:000182219700008
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKwong, FM
dc.contributor.authorWong, PS
dc.contributor.authorLung, ML
dc.date.accessioned2012-06-26T06:10:11Z
dc.date.available2012-06-26T06:10:11Z
dc.date.issued2003
dc.description.abstractGenetic alterations in 28 non-small cell lung carcinoma patients were detected on chromosomes 13q and 14q with microsatellite markers by polymerase chain reaction techniques. Loss of heterozygosity of up to 50% was detected with chromosome 13 markers and of up to 37% for chromosome 14. Microsatellite instability was as high as 30% on chromosome 13 and up to 19% on chromosome 14. Accumulated mutation frequencies of up to 94 and 93% were observed for chromosomes 13 and 14, respectively. Of eight tumors displaying high mutation frequencies, 1 also carried a K-ras mutation and 4 had p53 mutations. A significant association was observed between p53 mutations and genetic instability. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer Letters, 2003, v. 192 n. 2, p. 189-198 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0304-3835(02)00698-5
dc.identifier.doihttp://dx.doi.org/10.1016/S0304-3835(02)00698-5
dc.identifier.epage198
dc.identifier.isiWOS:000182219700008
dc.identifier.issn0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
dc.identifier.issue2
dc.identifier.pmid12668283
dc.identifier.scopuseid_2-s2.0-0037474747
dc.identifier.spage189
dc.identifier.urihttp://hdl.handle.net/10722/150775
dc.identifier.volume192
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
dc.publisher.placeIreland
dc.relation.ispartofCancer Letters
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Genetics - Pathology
dc.subject.meshChina
dc.subject.meshChromosomes, Human, Pair 13 - Genetics
dc.subject.meshChromosomes, Human, Pair 14 - Genetics
dc.subject.meshDna Mutational Analysis
dc.subject.meshFemale
dc.subject.meshGenes, P53 - Genetics
dc.subject.meshGenes, Ras - Genetics
dc.subject.meshGenetic Predisposition To Disease
dc.subject.meshHumans
dc.subject.meshLoss Of Heterozygosity - Genetics
dc.subject.meshLung Neoplasms - Genetics - Pathology
dc.subject.meshMale
dc.subject.meshMicrosatellite Repeats - Genetics
dc.subject.meshMiddle Aged
dc.subject.meshMutation - Genetics
dc.subject.meshNeoplasm Staging
dc.titleGenetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas
dc.typeArticle
Author Affiliations
  1. Hong Kong University of Science and Technology