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Article: Genetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas
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TitleGenetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas
 
AuthorsKwong, FM1
Wong, PS1
Lung, ML1
 
Issue Date2003
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
CitationCancer Letters, 2003, v. 192 n. 2, p. 189-198 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0304-3835(02)00698-5
 
AbstractGenetic alterations in 28 non-small cell lung carcinoma patients were detected on chromosomes 13q and 14q with microsatellite markers by polymerase chain reaction techniques. Loss of heterozygosity of up to 50% was detected with chromosome 13 markers and of up to 37% for chromosome 14. Microsatellite instability was as high as 30% on chromosome 13 and up to 19% on chromosome 14. Accumulated mutation frequencies of up to 94 and 93% were observed for chromosomes 13 and 14, respectively. Of eight tumors displaying high mutation frequencies, 1 also carried a K-ras mutation and 4 had p53 mutations. A significant association was observed between p53 mutations and genetic instability. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
 
ISSN0304-3835
2013 Impact Factor: 5.016
 
DOIhttp://dx.doi.org/10.1016/S0304-3835(02)00698-5
 
ISI Accession Number IDWOS:000182219700008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKwong, FM
 
dc.contributor.authorWong, PS
 
dc.contributor.authorLung, ML
 
dc.date.accessioned2012-06-26T06:10:11Z
 
dc.date.available2012-06-26T06:10:11Z
 
dc.date.issued2003
 
dc.description.abstractGenetic alterations in 28 non-small cell lung carcinoma patients were detected on chromosomes 13q and 14q with microsatellite markers by polymerase chain reaction techniques. Loss of heterozygosity of up to 50% was detected with chromosome 13 markers and of up to 37% for chromosome 14. Microsatellite instability was as high as 30% on chromosome 13 and up to 19% on chromosome 14. Accumulated mutation frequencies of up to 94 and 93% were observed for chromosomes 13 and 14, respectively. Of eight tumors displaying high mutation frequencies, 1 also carried a K-ras mutation and 4 had p53 mutations. A significant association was observed between p53 mutations and genetic instability. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCancer Letters, 2003, v. 192 n. 2, p. 189-198 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0304-3835(02)00698-5
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0304-3835(02)00698-5
 
dc.identifier.epage198
 
dc.identifier.isiWOS:000182219700008
 
dc.identifier.issn0304-3835
2013 Impact Factor: 5.016
 
dc.identifier.issue2
 
dc.identifier.pmid12668283
 
dc.identifier.scopuseid_2-s2.0-0037474747
 
dc.identifier.spage189
 
dc.identifier.urihttp://hdl.handle.net/10722/150775
 
dc.identifier.volume192
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
dc.publisher.placeIreland
 
dc.relation.ispartofCancer Letters
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Genetics - Pathology
 
dc.subject.meshChina
 
dc.subject.meshChromosomes, Human, Pair 13 - Genetics
 
dc.subject.meshChromosomes, Human, Pair 14 - Genetics
 
dc.subject.meshDna Mutational Analysis
 
dc.subject.meshFemale
 
dc.subject.meshGenes, P53 - Genetics
 
dc.subject.meshGenes, Ras - Genetics
 
dc.subject.meshGenetic Predisposition To Disease
 
dc.subject.meshHumans
 
dc.subject.meshLoss Of Heterozygosity - Genetics
 
dc.subject.meshLung Neoplasms - Genetics - Pathology
 
dc.subject.meshMale
 
dc.subject.meshMicrosatellite Repeats - Genetics
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMutation - Genetics
 
dc.subject.meshNeoplasm Staging
 
dc.titleGenetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas
 
dc.typeArticle
 
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Author Affiliations
  1. Hong Kong University of Science and Technology