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Article: Genetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas

TitleGenetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas
Authors
Issue Date2003
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2003, v. 192 n. 2, p. 189-198 How to Cite?
AbstractGenetic alterations in 28 non-small cell lung carcinoma patients were detected on chromosomes 13q and 14q with microsatellite markers by polymerase chain reaction techniques. Loss of heterozygosity of up to 50% was detected with chromosome 13 markers and of up to 37% for chromosome 14. Microsatellite instability was as high as 30% on chromosome 13 and up to 19% on chromosome 14. Accumulated mutation frequencies of up to 94 and 93% were observed for chromosomes 13 and 14, respectively. Of eight tumors displaying high mutation frequencies, 1 also carried a K-ras mutation and 4 had p53 mutations. A significant association was observed between p53 mutations and genetic instability. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150775
ISSN
2014 Impact Factor: 5.621
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, FMen_US
dc.contributor.authorWong, PSen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:10:11Z-
dc.date.available2012-06-26T06:10:11Z-
dc.date.issued2003en_US
dc.identifier.citationCancer Letters, 2003, v. 192 n. 2, p. 189-198en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/150775-
dc.description.abstractGenetic alterations in 28 non-small cell lung carcinoma patients were detected on chromosomes 13q and 14q with microsatellite markers by polymerase chain reaction techniques. Loss of heterozygosity of up to 50% was detected with chromosome 13 markers and of up to 37% for chromosome 14. Microsatellite instability was as high as 30% on chromosome 13 and up to 19% on chromosome 14. Accumulated mutation frequencies of up to 94 and 93% were observed for chromosomes 13 and 14, respectively. Of eight tumors displaying high mutation frequencies, 1 also carried a K-ras mutation and 4 had p53 mutations. A significant association was observed between p53 mutations and genetic instability. © 2002 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Genetics - Pathologyen_US
dc.subject.meshChinaen_US
dc.subject.meshChromosomes, Human, Pair 13 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 14 - Geneticsen_US
dc.subject.meshDna Mutational Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, P53 - Geneticsen_US
dc.subject.meshGenes, Ras - Geneticsen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshLoss Of Heterozygosity - Geneticsen_US
dc.subject.meshLung Neoplasms - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosatellite Repeats - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutation - Geneticsen_US
dc.subject.meshNeoplasm Stagingen_US
dc.titleGenetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3835(02)00698-5en_US
dc.identifier.pmid12668283en_US
dc.identifier.scopuseid_2-s2.0-0037474747en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037474747&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume192en_US
dc.identifier.issue2en_US
dc.identifier.spage189en_US
dc.identifier.epage198en_US
dc.identifier.isiWOS:000182219700008-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridKwong, FM=8158557800en_US
dc.identifier.scopusauthoridWong, PS=7403979959en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US

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