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Article: Evidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinoma
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TitleEvidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinoma
 
AuthorsGuan, XY1
Sham, JST1
Tai, LS1
Fang, Y2
Li, H1
Liang, Q2
 
Issue Date2003
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
 
CitationCancer Genetics And Cytogenetics, 2003, v. 140 n. 1, p. 45-48 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0165-4608(02)00654-4
 
AbstractLoss of 17p is one of the most frequent chromosomal alterations in primary hepatocellular carcinoma (HCC). In the present study, the association between loss of 17p and TP53 mutation was analyzed in 94 primary HCC of Chinese patients. Loss of one allele at 17p13.3 distal to the TP53 gene was observed in 48 of 94 HCC (51%), whereas loss of heterozygosity (LOH) at 17p13.1 near the TP53 gene was detected in 30 of 94 HCC (32%) and TP53 mutation was detected in only 22 of 94 HCC (23%). High frequency of LOH at 17p13.3 and relatively low frequency of TP53 mutation in the present study indicate that loss of function of a putative tumor suppressor gene at 17p13.3 may play a more important role than TP53 in HCC development. © 2003 Elsevier Science Inc. All rights reserved.
 
ISSN0165-4608
 
DOIhttp://dx.doi.org/10.1016/S0165-4608(02)00654-4
 
ISI Accession Number IDWOS:000180401900007
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorGuan, XY
 
dc.contributor.authorSham, JST
 
dc.contributor.authorTai, LS
 
dc.contributor.authorFang, Y
 
dc.contributor.authorLi, H
 
dc.contributor.authorLiang, Q
 
dc.date.accessioned2012-06-26T06:10:09Z
 
dc.date.available2012-06-26T06:10:09Z
 
dc.date.issued2003
 
dc.description.abstractLoss of 17p is one of the most frequent chromosomal alterations in primary hepatocellular carcinoma (HCC). In the present study, the association between loss of 17p and TP53 mutation was analyzed in 94 primary HCC of Chinese patients. Loss of one allele at 17p13.3 distal to the TP53 gene was observed in 48 of 94 HCC (51%), whereas loss of heterozygosity (LOH) at 17p13.1 near the TP53 gene was detected in 30 of 94 HCC (32%) and TP53 mutation was detected in only 22 of 94 HCC (23%). High frequency of LOH at 17p13.3 and relatively low frequency of TP53 mutation in the present study indicate that loss of function of a putative tumor suppressor gene at 17p13.3 may play a more important role than TP53 in HCC development. © 2003 Elsevier Science Inc. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCancer Genetics And Cytogenetics, 2003, v. 140 n. 1, p. 45-48 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0165-4608(02)00654-4
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0165-4608(02)00654-4
 
dc.identifier.epage48
 
dc.identifier.isiWOS:000180401900007
 
dc.identifier.issn0165-4608
 
dc.identifier.issue1
 
dc.identifier.pmid12550757
 
dc.identifier.scopuseid_2-s2.0-0037243435
 
dc.identifier.spage45
 
dc.identifier.urihttp://hdl.handle.net/10722/150772
 
dc.identifier.volume140
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer Genetics and Cytogenetics
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAlleles
 
dc.subject.meshCarcinoma, Hepatocellular - Genetics
 
dc.subject.meshCell Transformation, Neoplastic - Genetics
 
dc.subject.meshChina
 
dc.subject.meshChromosome Mapping
 
dc.subject.meshChromosomes, Human, Pair 17 - Genetics - Ultrastructure
 
dc.subject.meshGenes, Tumor Suppressor
 
dc.subject.meshGenes, P53
 
dc.subject.meshHumans
 
dc.subject.meshLiver Neoplasms - Genetics
 
dc.subject.meshLoss Of Heterozygosity
 
dc.subject.meshPolymerase Chain Reaction
 
dc.subject.meshPolymorphism, Single-Stranded Conformational
 
dc.titleEvidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinoma
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat Sen University of Medical Sciences