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Article: Evidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinoma

TitleEvidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinoma
Authors
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2003, v. 140 n. 1, p. 45-48 How to Cite?
AbstractLoss of 17p is one of the most frequent chromosomal alterations in primary hepatocellular carcinoma (HCC). In the present study, the association between loss of 17p and TP53 mutation was analyzed in 94 primary HCC of Chinese patients. Loss of one allele at 17p13.3 distal to the TP53 gene was observed in 48 of 94 HCC (51%), whereas loss of heterozygosity (LOH) at 17p13.1 near the TP53 gene was detected in 30 of 94 HCC (32%) and TP53 mutation was detected in only 22 of 94 HCC (23%). High frequency of LOH at 17p13.3 and relatively low frequency of TP53 mutation in the present study indicate that loss of function of a putative tumor suppressor gene at 17p13.3 may play a more important role than TP53 in HCC development. © 2003 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150772
ISSN
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, XYen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorTai, LSen_US
dc.contributor.authorFang, Yen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorLiang, Qen_US
dc.date.accessioned2012-06-26T06:10:09Z-
dc.date.available2012-06-26T06:10:09Z-
dc.date.issued2003en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2003, v. 140 n. 1, p. 45-48en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/150772-
dc.description.abstractLoss of 17p is one of the most frequent chromosomal alterations in primary hepatocellular carcinoma (HCC). In the present study, the association between loss of 17p and TP53 mutation was analyzed in 94 primary HCC of Chinese patients. Loss of one allele at 17p13.3 distal to the TP53 gene was observed in 48 of 94 HCC (51%), whereas loss of heterozygosity (LOH) at 17p13.1 near the TP53 gene was detected in 30 of 94 HCC (32%) and TP53 mutation was detected in only 22 of 94 HCC (23%). High frequency of LOH at 17p13.3 and relatively low frequency of TP53 mutation in the present study indicate that loss of function of a putative tumor suppressor gene at 17p13.3 may play a more important role than TP53 in HCC development. © 2003 Elsevier Science Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshCarcinoma, Hepatocellular - Geneticsen_US
dc.subject.meshCell Transformation, Neoplastic - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 17 - Genetics - Ultrastructureen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshGenes, P53en_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Geneticsen_US
dc.subject.meshLoss Of Heterozygosityen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_US
dc.titleEvidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(02)00654-4en_US
dc.identifier.pmid12550757en_US
dc.identifier.scopuseid_2-s2.0-0037243435en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037243435&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume140en_US
dc.identifier.issue1en_US
dc.identifier.spage45en_US
dc.identifier.epage48en_US
dc.identifier.isiWOS:000180401900007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridSham, JST=7101655565en_US
dc.identifier.scopusauthoridTai, LS=7004457333en_US
dc.identifier.scopusauthoridFang, Y=7403457405en_US
dc.identifier.scopusauthoridLi, H=26643419400en_US
dc.identifier.scopusauthoridLiang, Q=7102360486en_US

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