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Article: Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines

TitleIdentification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines
Authors
Issue Date2002
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2002, v. 62 n. 24, p. 7157-7161 How to Cite?
AbstractHigh-level amplification of DNA sequence at 19q13.1 is one of the frequent genetic alterations in ovarian cancer. In an attempt to verify the minimal amplified region (MAR) at 19q13.1 and to identify the target oncogenes, 49 probes within a region from D19S425 to D19S907 (∼19.5 cM) were used to survey the amplification status in four ovarian cancer cell lines that have been confirmed as containing amplification at 19q13.1. Two separated overlapping MARs, MAR1 (∼b) and MAR2 (∼1.1 Mb), were identified at 19q13.1. Two candidate oncogenes, AKT2 and SEI-1, were identified in MAR2. Amplification and overexpression of these two genes in four ovarian cancer cell lines were confirmed by Southern and Northern blot analyses. The proliferation-related function of AKT2 and SEI-1 suggests that both genes are likely to be biological targets of an amplification event at 19q13.1 in ovarian cancer and to play important roles in ovarian tumorigenesis.
Persistent Identifierhttp://hdl.handle.net/10722/150771
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, TCMen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorXie, Den_US
dc.contributor.authorFang, Yen_US
dc.contributor.authorHuo, KKen_US
dc.contributor.authorWu, QLen_US
dc.contributor.authorGuan, XYen_US
dc.date.accessioned2012-06-26T06:10:07Z-
dc.date.available2012-06-26T06:10:07Z-
dc.date.issued2002en_US
dc.identifier.citationCancer Research, 2002, v. 62 n. 24, p. 7157-7161en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/150771-
dc.description.abstractHigh-level amplification of DNA sequence at 19q13.1 is one of the frequent genetic alterations in ovarian cancer. In an attempt to verify the minimal amplified region (MAR) at 19q13.1 and to identify the target oncogenes, 49 probes within a region from D19S425 to D19S907 (∼19.5 cM) were used to survey the amplification status in four ovarian cancer cell lines that have been confirmed as containing amplification at 19q13.1. Two separated overlapping MARs, MAR1 (∼b) and MAR2 (∼1.1 Mb), were identified at 19q13.1. Two candidate oncogenes, AKT2 and SEI-1, were identified in MAR2. Amplification and overexpression of these two genes in four ovarian cancer cell lines were confirmed by Southern and Northern blot analyses. The proliferation-related function of AKT2 and SEI-1 suggests that both genes are likely to be biological targets of an amplification event at 19q13.1 in ovarian cancer and to play important roles in ovarian tumorigenesis.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshChromosomes, Human, Pair 19 - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshNuclear Proteinsen_US
dc.subject.meshOncogenes - Geneticsen_US
dc.subject.meshOvarian Neoplasms - Geneticsen_US
dc.subject.meshPhysical Chromosome Mapping - Methodsen_US
dc.subject.meshProtein-Serine-Threonine Kinasesen_US
dc.subject.meshProto-Oncogene Proteins - Geneticsen_US
dc.subject.meshProto-Oncogene Proteins C-Akten_US
dc.subject.meshTrans-Activators - Geneticsen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleIdentification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell linesen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12499249-
dc.identifier.scopuseid_2-s2.0-0037115418en_US
dc.identifier.hkuros80995-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037115418&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.issue24en_US
dc.identifier.spage7157en_US
dc.identifier.epage7161en_US
dc.identifier.isiWOS:000179929500006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTang, TCM=36867093400en_US
dc.identifier.scopusauthoridSham, JST=24472255400en_US
dc.identifier.scopusauthoridXie, D=35070710200en_US
dc.identifier.scopusauthoridFang, Y=7403457405en_US
dc.identifier.scopusauthoridHuo, KK=7004127179en_US
dc.identifier.scopusauthoridWu, QL=7404602639en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US

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