Article: Tissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinoma
| Title | Tissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinoma |
|---|---|
| Authors | Song, X1 Zhao, XR1 Wang, Y1 Zhou, JH1 Guan, XY1 Cao, Y1 |
| Keywords | Cell Cycle Multistage Nasopharyngeal Neoplasm Tissue Microarray Technique |
| Issue Date | 2002 |
| Citation | Progress In Biochemistry And Biophysics, 2002, v. 29 n. 3, p. 385-389 [How to Cite?] |
| Abstract | In order to investigate the relation between Cyclin D1 protein expression in multistage tissue of pathological changes during the nasopharyngeal carcinogenesis and nasopharyngeal carcinoma (NPC), the simple hyperplasia/metaplasia, atypical hyperplasia/metaplasia in the nasopharyngeal paracarcinoma mucous epithelium and NPC were studied for Cyclin D1 expression with immunohistochemical streptavidin-peroxidase (SP) method by tissue array techenique. The positive rates were 30.0% (3/10), 90.0% (18/20) and 62.9% (39/62) respectively, among which hightening "instantaneously" in the atypical hyperplasia/metaplasia appeared. It is shown high Cyclin D1 expression may be an early incident in the course of nasopharyngeal carcinogenesis, and that atypical hyperplasia/metaplasia probably be an important "toll-gate". |
| ISSN | 1000-3282 2011 Impact Factor: 0.554 2011 SCImago Journal Rankings: 0.034 |
| References | References in Scopus |
| dc.contributor.author | Song, X |
|---|---|
| dc.contributor.author | Zhao, XR |
| dc.contributor.author | Wang, Y |
| dc.contributor.author | Zhou, JH |
| dc.contributor.author | Guan, XY |
| dc.contributor.author | Cao, Y |
| dc.date.accessioned | 2012-06-26T06:10:04Z |
| dc.date.available | 2012-06-26T06:10:04Z |
| dc.date.issued | 2002 |
| dc.description.abstract | In order to investigate the relation between Cyclin D1 protein expression in multistage tissue of pathological changes during the nasopharyngeal carcinogenesis and nasopharyngeal carcinoma (NPC), the simple hyperplasia/metaplasia, atypical hyperplasia/metaplasia in the nasopharyngeal paracarcinoma mucous epithelium and NPC were studied for Cyclin D1 expression with immunohistochemical streptavidin-peroxidase (SP) method by tissue array techenique. The positive rates were 30.0% (3/10), 90.0% (18/20) and 62.9% (39/62) respectively, among which hightening "instantaneously" in the atypical hyperplasia/metaplasia appeared. It is shown high Cyclin D1 expression may be an early incident in the course of nasopharyngeal carcinogenesis, and that atypical hyperplasia/metaplasia probably be an important "toll-gate". |
| dc.description.nature | Link_to_subscribed_fulltext |
| dc.identifier.citation | Progress In Biochemistry And Biophysics, 2002, v. 29 n. 3, p. 385-389 [How to Cite?] |
| dc.identifier.epage | 389 |
| dc.identifier.issn | 1000-3282 2011 Impact Factor: 0.554 2011 SCImago Journal Rankings: 0.034 |
| dc.identifier.issue | 3 |
| dc.identifier.scopus | eid_2-s2.0-0036591334 |
| dc.identifier.spage | 385 |
| dc.identifier.uri | http://hdl.handle.net/10722/150767 |
| dc.identifier.volume | 29 |
| dc.language | eng |
| dc.publisher.place | China |
| dc.relation.ispartof | Progress in Biochemistry and Biophysics |
| dc.relation.references | References in Scopus |
| dc.subject | Cell Cycle |
| dc.subject | Multistage |
| dc.subject | Nasopharyngeal Neoplasm |
| dc.subject | Tissue Microarray Technique |
| dc.title | Tissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinoma |
| dc.type | Article |
Author Affiliations
- Central South University China