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Article: Tissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinoma

TitleTissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinoma
Authors
KeywordsCell Cycle
Multistage
Nasopharyngeal Neoplasm
Tissue Microarray Technique
Issue Date2002
Citation
Progress In Biochemistry And Biophysics, 2002, v. 29 n. 3, p. 385-389 How to Cite?
Abstract
In order to investigate the relation between Cyclin D1 protein expression in multistage tissue of pathological changes during the nasopharyngeal carcinogenesis and nasopharyngeal carcinoma (NPC), the simple hyperplasia/metaplasia, atypical hyperplasia/metaplasia in the nasopharyngeal paracarcinoma mucous epithelium and NPC were studied for Cyclin D1 expression with immunohistochemical streptavidin-peroxidase (SP) method by tissue array techenique. The positive rates were 30.0% (3/10), 90.0% (18/20) and 62.9% (39/62) respectively, among which hightening "instantaneously" in the atypical hyperplasia/metaplasia appeared. It is shown high Cyclin D1 expression may be an early incident in the course of nasopharyngeal carcinogenesis, and that atypical hyperplasia/metaplasia probably be an important "toll-gate".
Persistent Identifierhttp://hdl.handle.net/10722/150767
ISSN
2013 Impact Factor: 0.290
2013 SCImago Journal Rankings: 0.132
References

 

Author Affiliations
  1. Central South University China
DC FieldValueLanguage
dc.contributor.authorSong, Xen_US
dc.contributor.authorZhao, XRen_US
dc.contributor.authorWang, Yen_US
dc.contributor.authorZhou, JHen_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorCao, Yen_US
dc.date.accessioned2012-06-26T06:10:04Z-
dc.date.available2012-06-26T06:10:04Z-
dc.date.issued2002en_US
dc.identifier.citationProgress In Biochemistry And Biophysics, 2002, v. 29 n. 3, p. 385-389en_US
dc.identifier.issn1000-3282en_US
dc.identifier.urihttp://hdl.handle.net/10722/150767-
dc.description.abstractIn order to investigate the relation between Cyclin D1 protein expression in multistage tissue of pathological changes during the nasopharyngeal carcinogenesis and nasopharyngeal carcinoma (NPC), the simple hyperplasia/metaplasia, atypical hyperplasia/metaplasia in the nasopharyngeal paracarcinoma mucous epithelium and NPC were studied for Cyclin D1 expression with immunohistochemical streptavidin-peroxidase (SP) method by tissue array techenique. The positive rates were 30.0% (3/10), 90.0% (18/20) and 62.9% (39/62) respectively, among which hightening "instantaneously" in the atypical hyperplasia/metaplasia appeared. It is shown high Cyclin D1 expression may be an early incident in the course of nasopharyngeal carcinogenesis, and that atypical hyperplasia/metaplasia probably be an important "toll-gate".en_US
dc.languageengen_US
dc.relation.ispartofProgress in Biochemistry and Biophysicsen_US
dc.subjectCell Cycleen_US
dc.subjectMultistageen_US
dc.subjectNasopharyngeal Neoplasmen_US
dc.subjectTissue Microarray Techniqueen_US
dc.titleTissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0036591334en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036591334&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issue3en_US
dc.identifier.spage385en_US
dc.identifier.epage389en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridSong, X=13002663000en_US
dc.identifier.scopusauthoridZhao, XR=9271473900en_US
dc.identifier.scopusauthoridWang, Y=10641308400en_US
dc.identifier.scopusauthoridZhou, JH=13409477800en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridCao, Y=7404524499en_US

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