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Article: Tissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinoma
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TitleTissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinoma
 
AuthorsSong, X1
Zhao, XR1
Wang, Y1
Zhou, JH1
Guan, XY1
Cao, Y1
 
KeywordsCell Cycle
Multistage
Nasopharyngeal Neoplasm
Tissue Microarray Technique
 
Issue Date2002
 
CitationProgress In Biochemistry And Biophysics, 2002, v. 29 n. 3, p. 385-389 [How to Cite?]
 
AbstractIn order to investigate the relation between Cyclin D1 protein expression in multistage tissue of pathological changes during the nasopharyngeal carcinogenesis and nasopharyngeal carcinoma (NPC), the simple hyperplasia/metaplasia, atypical hyperplasia/metaplasia in the nasopharyngeal paracarcinoma mucous epithelium and NPC were studied for Cyclin D1 expression with immunohistochemical streptavidin-peroxidase (SP) method by tissue array techenique. The positive rates were 30.0% (3/10), 90.0% (18/20) and 62.9% (39/62) respectively, among which hightening "instantaneously" in the atypical hyperplasia/metaplasia appeared. It is shown high Cyclin D1 expression may be an early incident in the course of nasopharyngeal carcinogenesis, and that atypical hyperplasia/metaplasia probably be an important "toll-gate".
 
ISSN1000-3282
2012 SCImago Journal Rankings: 0.252
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSong, X
 
dc.contributor.authorZhao, XR
 
dc.contributor.authorWang, Y
 
dc.contributor.authorZhou, JH
 
dc.contributor.authorGuan, XY
 
dc.contributor.authorCao, Y
 
dc.date.accessioned2012-06-26T06:10:04Z
 
dc.date.available2012-06-26T06:10:04Z
 
dc.date.issued2002
 
dc.description.abstractIn order to investigate the relation between Cyclin D1 protein expression in multistage tissue of pathological changes during the nasopharyngeal carcinogenesis and nasopharyngeal carcinoma (NPC), the simple hyperplasia/metaplasia, atypical hyperplasia/metaplasia in the nasopharyngeal paracarcinoma mucous epithelium and NPC were studied for Cyclin D1 expression with immunohistochemical streptavidin-peroxidase (SP) method by tissue array techenique. The positive rates were 30.0% (3/10), 90.0% (18/20) and 62.9% (39/62) respectively, among which hightening "instantaneously" in the atypical hyperplasia/metaplasia appeared. It is shown high Cyclin D1 expression may be an early incident in the course of nasopharyngeal carcinogenesis, and that atypical hyperplasia/metaplasia probably be an important "toll-gate".
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationProgress In Biochemistry And Biophysics, 2002, v. 29 n. 3, p. 385-389 [How to Cite?]
 
dc.identifier.epage389
 
dc.identifier.issn1000-3282
2012 SCImago Journal Rankings: 0.252
 
dc.identifier.issue3
 
dc.identifier.scopuseid_2-s2.0-0036591334
 
dc.identifier.spage385
 
dc.identifier.urihttp://hdl.handle.net/10722/150767
 
dc.identifier.volume29
 
dc.languageeng
 
dc.publisher.placeChina
 
dc.relation.ispartofProgress in Biochemistry and Biophysics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCell Cycle
 
dc.subjectMultistage
 
dc.subjectNasopharyngeal Neoplasm
 
dc.subjectTissue Microarray Technique
 
dc.titleTissue microarray analysis of cyclin D1 gene overexpression in the multistage carcinogenesis of nasopharyngeal carcinoma
 
dc.typeArticle
 
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<contributor.author>Zhao, XR</contributor.author>
<contributor.author>Wang, Y</contributor.author>
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<contributor.author>Guan, XY</contributor.author>
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Author Affiliations
  1. Central South University China