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Article: Characterization of a complex chromosome rearrangement involving 6q in a melanoma cell line by chromosome microdissection

TitleCharacterization of a complex chromosome rearrangement involving 6q in a melanoma cell line by chromosome microdissection
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2002, v. 134 n. 1, p. 65-70 How to Cite?
AbstractDeletion of 6q is one of the most frequent chromosomal alterations in human malignant melanoma. Recently, we used chromosome painting probes of 6p and 6q to study 21 melanoma cell lines. A reciprocal translocation between chromosomes 6q and 17p was detected in one cell line (UACC-930). Upon further characterization of the translocation marker using the micro fluorescence in situ hybridization (FISH) technique, a complex rearrangement including an inversion of 6q and a translocation between the inverted 6q and 17p, [der(6)inv(6)(q16q27)t(6;17)(q26;p13)], was detected. A yeast artificial chromosome (YAC) clone spanning the breakpoint at 6q16 was isolated by the FISH screen. Loss of one or more copies of the YAC clone was also detected in 10 of 12 melanoma cell lines. This result implies that the YAC clone may contain a putative tumor suppressor gene related to the pathogenesis of malignant melanoma. Further characterizations of the breakpoint at 6q16 and molecular cloning breakpoints at 6q27 and 17p13 are in progress. © 2002 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150766
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, XYen_US
dc.contributor.authorZhang, HEen_US
dc.contributor.authorZhou, Hen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorFung, JMWen_US
dc.contributor.authorTrent, JMen_US
dc.date.accessioned2012-06-26T06:10:03Z-
dc.date.available2012-06-26T06:10:03Z-
dc.date.issued2002en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2002, v. 134 n. 1, p. 65-70en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/150766-
dc.description.abstractDeletion of 6q is one of the most frequent chromosomal alterations in human malignant melanoma. Recently, we used chromosome painting probes of 6p and 6q to study 21 melanoma cell lines. A reciprocal translocation between chromosomes 6q and 17p was detected in one cell line (UACC-930). Upon further characterization of the translocation marker using the micro fluorescence in situ hybridization (FISH) technique, a complex rearrangement including an inversion of 6q and a translocation between the inverted 6q and 17p, [der(6)inv(6)(q16q27)t(6;17)(q26;p13)], was detected. A yeast artificial chromosome (YAC) clone spanning the breakpoint at 6q16 was isolated by the FISH screen. Loss of one or more copies of the YAC clone was also detected in 10 of 12 melanoma cell lines. This result implies that the YAC clone may contain a putative tumor suppressor gene related to the pathogenesis of malignant melanoma. Further characterizations of the breakpoint at 6q16 and molecular cloning breakpoints at 6q27 and 17p13 are in progress. © 2002 Elsevier Science Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshChromosome Breakage - Geneticsen_US
dc.subject.meshChromosomes, Artificial, Yeast - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 17 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 6 - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMelanoma - Genetics - Pathologyen_US
dc.subject.meshTranslocation, Geneticen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleCharacterization of a complex chromosome rearrangement involving 6q in a melanoma cell line by chromosome microdissectionen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(01)00608-2en_US
dc.identifier.pmid11996799-
dc.identifier.scopuseid_2-s2.0-0036539554en_US
dc.identifier.hkuros72343-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036539554&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume134en_US
dc.identifier.issue1en_US
dc.identifier.spage65en_US
dc.identifier.epage70en_US
dc.identifier.isiWOS:000175165700013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridZhang, HE=7409194743en_US
dc.identifier.scopusauthoridZhou, H=38062649800en_US
dc.identifier.scopusauthoridSham, JST=7101655565en_US
dc.identifier.scopusauthoridFung, JMW=23469161200en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US

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