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Article: Change in olfaction after radiotherapy for nasopharyngeal cancer - A prospective study

TitleChange in olfaction after radiotherapy for nasopharyngeal cancer - A prospective study
Authors
Issue Date2002
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/amjoto
Citation
American Journal Of Otolaryngology - Head And Neck Medicine And Surgery, 2002, v. 23 n. 4, p. 209-214 How to Cite?
AbstractPurpose: To evaluate the changes in olfactory function in patients with nasopharyngeal carcinoma who have received radiation to the head and neck. Materials and Methods: Olfactory function of consecutive patients with nasopharyngeal carcinoma was assessed prospectively before irradiation and serially up to 1 year after radiotherapy by the Sniffin' Sticks (Erlangen, Germany) olfactory function test and by a patient symptom visual analogue scale. Results: Fifty-eight patients were recruited before radiotherapy was commenced. Three patients could not give a reliable response to the Sniffin' Sticks test even in this first assessment, and 7 patients did not return for evaluation after irradiation. Forty-eight patients were available for follow-up assessment. Mean olfactory threshold scores by the Sniffin' Sticks test were found to deteriorate significantly at 12 months when compared with the scores before irradiation (8.3 at 12 months vs 11.5 before irradiation; P = .001). Scores for olfactory discrimination and for identification did not exhibit any significant changes when assessed at 12 months (P gt; .05 for both). Subjective patient assessment of olfactory function with the visual analogue scale at 12 months did not demonstrate any significant differences when compared with patients' assessment before irradiation (P = .90). An increase in discharge was the only nasal symptom that demonstrated a significant change at 12 months when compared with the assessment before irradiation (P lt; 001). Conclusions: Deterioration in olfactory threshold scores was found at 12 months after irradiation and was not noticed by the patients. Copyright 2002, Elsevier Science (USA). All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150764
ISSN
2015 Impact Factor: 0.933
2015 SCImago Journal Rankings: 0.590
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, WKen_US
dc.contributor.authorKwong, DLWen_US
dc.contributor.authorWei, WIen_US
dc.contributor.authorSham, JSTen_US
dc.date.accessioned2012-06-26T06:10:02Z-
dc.date.available2012-06-26T06:10:02Z-
dc.date.issued2002en_US
dc.identifier.citationAmerican Journal Of Otolaryngology - Head And Neck Medicine And Surgery, 2002, v. 23 n. 4, p. 209-214en_US
dc.identifier.issn0196-0709en_US
dc.identifier.urihttp://hdl.handle.net/10722/150764-
dc.description.abstractPurpose: To evaluate the changes in olfactory function in patients with nasopharyngeal carcinoma who have received radiation to the head and neck. Materials and Methods: Olfactory function of consecutive patients with nasopharyngeal carcinoma was assessed prospectively before irradiation and serially up to 1 year after radiotherapy by the Sniffin' Sticks (Erlangen, Germany) olfactory function test and by a patient symptom visual analogue scale. Results: Fifty-eight patients were recruited before radiotherapy was commenced. Three patients could not give a reliable response to the Sniffin' Sticks test even in this first assessment, and 7 patients did not return for evaluation after irradiation. Forty-eight patients were available for follow-up assessment. Mean olfactory threshold scores by the Sniffin' Sticks test were found to deteriorate significantly at 12 months when compared with the scores before irradiation (8.3 at 12 months vs 11.5 before irradiation; P = .001). Scores for olfactory discrimination and for identification did not exhibit any significant changes when assessed at 12 months (P gt; .05 for both). Subjective patient assessment of olfactory function with the visual analogue scale at 12 months did not demonstrate any significant differences when compared with patients' assessment before irradiation (P = .90). An increase in discharge was the only nasal symptom that demonstrated a significant change at 12 months when compared with the assessment before irradiation (P lt; 001). Conclusions: Deterioration in olfactory threshold scores was found at 12 months after irradiation and was not noticed by the patients. Copyright 2002, Elsevier Science (USA). All rights reserved.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/amjotoen_US
dc.relation.ispartofAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgeryen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Physiopathology - Radiotherapyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSelf-Assessmenten_US
dc.subject.meshSmell - Physiologyen_US
dc.titleChange in olfaction after radiotherapy for nasopharyngeal cancer - A prospective studyen_US
dc.typeArticleen_US
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_US
dc.identifier.emailWei, WI:hrmswwi@hku.hken_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1053/ajot.2002.123436en_US
dc.identifier.pmid12105785-
dc.identifier.scopuseid_2-s2.0-0036303542en_US
dc.identifier.hkuros70220-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036303542&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue4en_US
dc.identifier.spage209en_US
dc.identifier.epage214en_US
dc.identifier.isiWOS:000176673200004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, WK=7402968844en_US
dc.identifier.scopusauthoridKwong, DLW=15744231600en_US
dc.identifier.scopusauthoridWei, WI=7403321552en_US
dc.identifier.scopusauthoridSham, JST=24472255400en_US

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