File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer

TitleIsolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer
Authors
Issue Date2001
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2001, v. 61 n. 9, p. 3806-3809 How to Cite?
AbstractAmplification of 3q25-q26 was one of the most frequent chromosomal alterations in human ovarian carcinoma. A chromosome microdissection hybrid selection method was applied to isolate transcribed sequences from a primary ovarian cancer containing high-copy-number amplification of 3q26 using 3q26 band-specific DNAs generated by chromosome microdissection. Using this method, we have isolated a novel candidate oncogene eIF-5A2 (eukaryotic initiation factor 5A2). eIF-5A2 shares 82% identity of amino acid sequence with eIF-5A including the minimum domain needed for eIF-5A maturation by hypusine modification at lysine-50 residue. Amplification and overexpression of eIF-5A2 was frequently detected in primary ovarian cancers and ovarian cancer cell lines. The proliferation-related function of eIF-5A supports that eIF-5A2 is a candidate oncogene related to the development of ovarian cancer.
Persistent Identifierhttp://hdl.handle.net/10722/150760
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, XYen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorTang, TCMen_US
dc.contributor.authorFang, Yen_US
dc.contributor.authorHuo, KKen_US
dc.contributor.authorYang, JMen_US
dc.date.accessioned2012-06-26T06:09:59Z-
dc.date.available2012-06-26T06:09:59Z-
dc.date.issued2001en_US
dc.identifier.citationCancer Research, 2001, v. 61 n. 9, p. 3806-3809en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/150760-
dc.description.abstractAmplification of 3q25-q26 was one of the most frequent chromosomal alterations in human ovarian carcinoma. A chromosome microdissection hybrid selection method was applied to isolate transcribed sequences from a primary ovarian cancer containing high-copy-number amplification of 3q26 using 3q26 band-specific DNAs generated by chromosome microdissection. Using this method, we have isolated a novel candidate oncogene eIF-5A2 (eukaryotic initiation factor 5A2). eIF-5A2 shares 82% identity of amino acid sequence with eIF-5A including the minimum domain needed for eIF-5A maturation by hypusine modification at lysine-50 residue. Amplification and overexpression of eIF-5A2 was frequently detected in primary ovarian cancers and ovarian cancer cell lines. The proliferation-related function of eIF-5A supports that eIF-5A2 is a candidate oncogene related to the development of ovarian cancer.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChickensen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 3en_US
dc.subject.meshDna, Neoplasm - Genetics - Isolation & Purificationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshOvarian Neoplasms - Geneticsen_US
dc.subject.meshPeptide Initiation Factors - Geneticsen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.titleIsolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian canceren_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid11325856-
dc.identifier.scopuseid_2-s2.0-0035328882en_US
dc.identifier.hkuros61897-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035328882&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume61en_US
dc.identifier.issue9en_US
dc.identifier.spage3806en_US
dc.identifier.epage3809en_US
dc.identifier.isiWOS:000168485400044-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridSham, JST=24472255400en_US
dc.identifier.scopusauthoridTang, TCM=36867093400en_US
dc.identifier.scopusauthoridFang, Y=7403457405en_US
dc.identifier.scopusauthoridHuo, KK=7004127179en_US
dc.identifier.scopusauthoridYang, JM=12445064900en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats