File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Comparative genomic hybridization analysis of nasopharygeal carcinoma:consistent patterns of genetic aberrations and clinicopathological correlations

TitleComparative genomic hybridization analysis of nasopharygeal carcinoma:consistent patterns of genetic aberrations and clinicopathological correlations
Authors
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2001, v. 126 n. 1, p. 63-67 How to Cite?
AbstractTo define the patterns of genetic imbalances in nasopharyngeal carcinoma (NPC), we studied 30 primary NPC tumors with comparative genomic hybridization (CGH). The common sites of chromosomal gains were found in descending order of frequency in 12p11.2-p12 (36%), 12q14-q21 (33%), 2q24-q31 (23%), 1q31-qter (20%), 3q13 (20%), 1q13.3 (20%), 5q21 (17%), 6q14-q22 (13%), 7q21 (13%), 8q11.2-q23 (13%) and 18q12-qter (13%). The common sites of chromosomal loss were at 3p14-p21 (20%), 11q23-qter (20%), 16q21-qter (17%) and 14q24-qter (13%). Correlation with clinicopathologic features showed that 3p loss was associated with a significantly higher risk of death related to recurrence as compared with patients without 3p loss (50% vs. 9%, P=.029). The presence of 16q loss was associated with more advanced stage tumors (stages I & II: 6% vs. stages III & IV: 33%, P=.046). We conclude that consistent patterns of genetic imbalances can be observed in NPC. Deletion of 3p and 16q were associated with higher risk of tumor recurrence and advanced stage cancer. Copyright © 2001 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/150759
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChien, Gen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorKwong, Den_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2012-06-26T06:09:58Z-
dc.date.available2012-06-26T06:09:58Z-
dc.date.issued2001en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2001, v. 126 n. 1, p. 63-67en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150759-
dc.description.abstractTo define the patterns of genetic imbalances in nasopharyngeal carcinoma (NPC), we studied 30 primary NPC tumors with comparative genomic hybridization (CGH). The common sites of chromosomal gains were found in descending order of frequency in 12p11.2-p12 (36%), 12q14-q21 (33%), 2q24-q31 (23%), 1q31-qter (20%), 3q13 (20%), 1q13.3 (20%), 5q21 (17%), 6q14-q22 (13%), 7q21 (13%), 8q11.2-q23 (13%) and 18q12-qter (13%). The common sites of chromosomal loss were at 3p14-p21 (20%), 11q23-qter (20%), 16q21-qter (17%) and 14q24-qter (13%). Correlation with clinicopathologic features showed that 3p loss was associated with a significantly higher risk of death related to recurrence as compared with patients without 3p loss (50% vs. 9%, P=.029). The presence of 16q loss was associated with more advanced stage tumors (stages I & II: 6% vs. stages III & IV: 33%, P=.046). We conclude that consistent patterns of genetic imbalances can be observed in NPC. Deletion of 3p and 16q were associated with higher risk of tumor recurrence and advanced stage cancer. Copyright © 2001 Elsevier Science Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshHumansen_US
dc.subject.meshNasopharyngeal Neoplasms - Genetics - Pathologyen_US
dc.subject.meshNucleic Acid Hybridization - Methodsen_US
dc.titleComparative genomic hybridization analysis of nasopharygeal carcinoma:consistent patterns of genetic aberrations and clinicopathological correlationsen_HK
dc.typeArticleen_HK
dc.identifier.emailKwong, D:dlwkwong@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(00)00392-7en_HK
dc.identifier.pmid11343782-
dc.identifier.scopuseid_2-s2.0-0035304396en_HK
dc.identifier.hkuros72127-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035304396&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume126en_HK
dc.identifier.issue1en_HK
dc.identifier.spage63en_HK
dc.identifier.epage67en_HK
dc.identifier.isiWOS:000168737000012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChien, G=36641226500en_HK
dc.identifier.scopusauthoridYuen, PW=7103124007en_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats