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Article: Serial HRCT lung changes after 3-field radiation treatment of breast cancer

TitleSerial HRCT lung changes after 3-field radiation treatment of breast cancer
Authors
Issue Date2000
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/crad
Citation
Clinical Radiology, 2000, v. 55 n. 11, p. 817-824 How to Cite?
AbstractAims: To document serial high resolution computed tomography (HRCT) features of lung injury after 3-field radiotherapy for breast cancer. Materials and methods: Thirty women who received opposing tangential chest wall and supraclavicular field (SCF) irradiation after breast surgery were recruited. Thoracic HRCT was performed before and at 1,3,6 and 12 months after radiotherapy (RT). Lung injury at 3 months was quantified by applying a scoring system to each HRCT section. Findings were correlated with spirometric lung function tests. Results: There was HRCT evidence of lung injury in 27 (90%) women at 1 month and in all 30 patients at 3 months. Spirometric lung function declined post-RT (P < 0.05), correlating with an increased SCF acute lung injury score at 3 months [r = -0.54 and -0.46, P = 0.01 and 0.03 for forced expiratory volume in 1st (FEV1) and forced vital capacity (FVC), respectively]. Lung injury on HRCT progressed from ground glass opacification at 1 month to nodular consolidation (3 months), increasing linear densities (6 months), and finally to residual subpleural linear and dense opacities (12 months). Conclusion: There is a high incidence of lung injury associated with 3-field radiotherapy for breast cancer, with concurrent SCF irradiation increasing the risk of lung damage and functional impairment. A characteristic sequence of HRCT changes is seen in most patients receiving this type of radiotherapy. © 2000 The Royal College of Radiologists.
Persistent Identifierhttp://hdl.handle.net/10722/150757
ISSN
2015 Impact Factor: 2.151
2015 SCImago Journal Rankings: 0.864
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, GCen_US
dc.contributor.authorKwong, DLWen_US
dc.contributor.authorChan, KNen_US
dc.contributor.authorNgan, Hen_US
dc.contributor.authorLock, DTWen_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorChan, FLen_US
dc.contributor.authorAu, Gen_US
dc.contributor.authorTsang, KWTen_US
dc.date.accessioned2012-06-26T06:09:57Z-
dc.date.available2012-06-26T06:09:57Z-
dc.date.issued2000en_US
dc.identifier.citationClinical Radiology, 2000, v. 55 n. 11, p. 817-824en_US
dc.identifier.issn0009-9260en_US
dc.identifier.urihttp://hdl.handle.net/10722/150757-
dc.description.abstractAims: To document serial high resolution computed tomography (HRCT) features of lung injury after 3-field radiotherapy for breast cancer. Materials and methods: Thirty women who received opposing tangential chest wall and supraclavicular field (SCF) irradiation after breast surgery were recruited. Thoracic HRCT was performed before and at 1,3,6 and 12 months after radiotherapy (RT). Lung injury at 3 months was quantified by applying a scoring system to each HRCT section. Findings were correlated with spirometric lung function tests. Results: There was HRCT evidence of lung injury in 27 (90%) women at 1 month and in all 30 patients at 3 months. Spirometric lung function declined post-RT (P < 0.05), correlating with an increased SCF acute lung injury score at 3 months [r = -0.54 and -0.46, P = 0.01 and 0.03 for forced expiratory volume in 1st (FEV1) and forced vital capacity (FVC), respectively]. Lung injury on HRCT progressed from ground glass opacification at 1 month to nodular consolidation (3 months), increasing linear densities (6 months), and finally to residual subpleural linear and dense opacities (12 months). Conclusion: There is a high incidence of lung injury associated with 3-field radiotherapy for breast cancer, with concurrent SCF irradiation increasing the risk of lung damage and functional impairment. A characteristic sequence of HRCT changes is seen in most patients receiving this type of radiotherapy. © 2000 The Royal College of Radiologists.en_US
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/craden_US
dc.relation.ispartofClinical Radiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBreast Neoplasms - Radiotherapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volume - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLung - Radiation Effects - Radiographyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRadiation Injuries - Radiographyen_US
dc.subject.meshRadiotherapy - Adverse Effects - Methodsen_US
dc.subject.meshRespiratory Distress Syndrome, Adult - Radiographyen_US
dc.subject.meshTomography, X-Ray Computed - Methodsen_US
dc.subject.meshVital Capacity - Physiologyen_US
dc.titleSerial HRCT lung changes after 3-field radiation treatment of breast canceren_US
dc.typeArticleen_US
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1053/crad.2000.0542en_US
dc.identifier.pmid11069735-
dc.identifier.scopuseid_2-s2.0-0034527239en_US
dc.identifier.hkuros61692-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034527239&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume55en_US
dc.identifier.issue11en_US
dc.identifier.spage817en_US
dc.identifier.epage824en_US
dc.identifier.isiWOS:000165353000002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridOoi, GC=7006176119en_US
dc.identifier.scopusauthoridKwong, DLW=15744231600en_US
dc.identifier.scopusauthoridChan, KN=15737866400en_US
dc.identifier.scopusauthoridNgan, H=7102173824en_US
dc.identifier.scopusauthoridLock, DTW=7003694952en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridChan, FL=7202586444en_US
dc.identifier.scopusauthoridAu, G=7003748615en_US
dc.identifier.scopusauthoridTsang, KWT=7201555024en_US

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