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Article: P53 inactivating mutations in Chinese breast carcinomas

TitleP53 inactivating mutations in Chinese breast carcinomas
Authors
Issue Date2000
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 2000, v. 7 n. 2, p. 381-385 How to Cite?
AbstractWhile previous reports on breast cancers indicate that Caucasian women have a low frequency of p53 mutations, higher frequencies of mutations are reported in some Japanese populations. There are few reports regarding p53 mutations in Chinese breast carcinomas. Using a previously established sensitive p53 yeast functional assay, we screened 23 Chinese breast carcinomas for mutations. The p53 was mutated in 5/23 (21.7%) specimens. Two of these mutations were detected in exon 5 and one was detected in each of exons 6, 7 and 8. All of these mutations have previously been shown to be mutated in Caucasian and Japanese breast cancers, but two have not previously been observed in Chinese breast cancers and one has also not been observed in Japanese. p53, mutation, Chinese breast cancer.
Persistent Identifierhttp://hdl.handle.net/10722/150756
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
References

 

DC FieldValueLanguage
dc.contributor.authorLung, MLIen_US
dc.date.accessioned2012-06-26T06:09:56Z-
dc.date.available2012-06-26T06:09:56Z-
dc.date.issued2000en_US
dc.identifier.citationOncology Reports, 2000, v. 7 n. 2, p. 381-385en_US
dc.identifier.issn1021-335Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/150756-
dc.description.abstractWhile previous reports on breast cancers indicate that Caucasian women have a low frequency of p53 mutations, higher frequencies of mutations are reported in some Japanese populations. There are few reports regarding p53 mutations in Chinese breast carcinomas. Using a previously established sensitive p53 yeast functional assay, we screened 23 Chinese breast carcinomas for mutations. The p53 was mutated in 5/23 (21.7%) specimens. Two of these mutations were detected in exon 5 and one was detected in each of exons 6, 7 and 8. All of these mutations have previously been shown to be mutated in Caucasian and Japanese breast cancers, but two have not previously been observed in Chinese breast cancers and one has also not been observed in Japanese. p53, mutation, Chinese breast cancer.en_US
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_US
dc.relation.ispartofOncology Reportsen_US
dc.titleP53 inactivating mutations in Chinese breast carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailLung, MLI:mlilung@hku.hken_US
dc.identifier.authorityLung, MLI=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0034146578en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034146578&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue2en_US
dc.identifier.spage381en_US
dc.identifier.epage385en_US
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridLung, MLI=7006411788en_US

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