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Article: Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization
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TitleRecurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization
 
AuthorsGuan, XY2
Fang, Y3
Sham, JST
Kwong, DLW
Zhang, Y3
Liang, Q3
Li, H3
Zhou, H1
Trent, JM1
 
Issue Date2000
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
 
CitationGenes Chromosomes And Cancer, 2000, v. 29 n. 2, p. 110-116 [How to Cite?]
DOI: http://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V
 
AbstractHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and has a very poor prognosis. Fifty primary HCC cases have been analyzed in the present study to explore the association between genomic alteration in primary HCC and clinical features. Several recurrent chromosomal abnormalities were identified in this study. The most frequently detected chromosomal gains involved chromosome arms 1q (33/50 cases, 66%), 8q (24/50 cases, 48%), and 20q (10/50 cases, 20%). High-copy-number amplifications involving lq (4 cases), 8q (3 cases), and 20q (3 cases) were detected, and a minimum overlapping amplified region at 1q12-q22 was identified. The most frequently detected loss of chromosomal material involved 16q (35/50 cases, 70%), 17p (26/50 cases, 52%), 19p (21/50 cases, 42%), 4q (20/50 cases, 40%), 1p (18/50 cases, 36%), 8p (16/50 cases, 32%), and 22q (14/50 cases, 28%). The associations between genomic alterations detected in the present study and clinical features including clinical stage, tumor size, HBV infection, chronic Fiver disease, and liver cirrhosis were explored. Our CGH results suggest that the gain of 20q and deletion of 8p are late genetic alterations in HCC, because the incidence of these alterations was obviously increased in the advanced clinical stages. Another finding showed that loss of 8p and gain of 8q and 20q are associated with tumor size. The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression. (C) 2000 Wiley-Liss, Inc.
 
ISSN1045-2257
2013 Impact Factor: 3.836
 
DOIhttp://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V
 
ISI Accession Number IDWOS:000089120300004
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorGuan, XY
 
dc.contributor.authorFang, Y
 
dc.contributor.authorSham, JST
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorZhang, Y
 
dc.contributor.authorLiang, Q
 
dc.contributor.authorLi, H
 
dc.contributor.authorZhou, H
 
dc.contributor.authorTrent, JM
 
dc.date.accessioned2012-06-26T06:09:55Z
 
dc.date.available2012-06-26T06:09:55Z
 
dc.date.issued2000
 
dc.description.abstractHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and has a very poor prognosis. Fifty primary HCC cases have been analyzed in the present study to explore the association between genomic alteration in primary HCC and clinical features. Several recurrent chromosomal abnormalities were identified in this study. The most frequently detected chromosomal gains involved chromosome arms 1q (33/50 cases, 66%), 8q (24/50 cases, 48%), and 20q (10/50 cases, 20%). High-copy-number amplifications involving lq (4 cases), 8q (3 cases), and 20q (3 cases) were detected, and a minimum overlapping amplified region at 1q12-q22 was identified. The most frequently detected loss of chromosomal material involved 16q (35/50 cases, 70%), 17p (26/50 cases, 52%), 19p (21/50 cases, 42%), 4q (20/50 cases, 40%), 1p (18/50 cases, 36%), 8p (16/50 cases, 32%), and 22q (14/50 cases, 28%). The associations between genomic alterations detected in the present study and clinical features including clinical stage, tumor size, HBV infection, chronic Fiver disease, and liver cirrhosis were explored. Our CGH results suggest that the gain of 20q and deletion of 8p are late genetic alterations in HCC, because the incidence of these alterations was obviously increased in the advanced clinical stages. Another finding showed that loss of 8p and gain of 8q and 20q are associated with tumor size. The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression. (C) 2000 Wiley-Liss, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationGenes Chromosomes And Cancer, 2000, v. 29 n. 2, p. 110-116 [How to Cite?]
DOI: http://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V
 
dc.identifier.doihttp://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V
 
dc.identifier.epage116
 
dc.identifier.hkuros61908
 
dc.identifier.isiWOS:000089120300004
 
dc.identifier.issn1045-2257
2013 Impact Factor: 3.836
 
dc.identifier.issue2
 
dc.identifier.pmid10959090
 
dc.identifier.scopuseid_2-s2.0-0033843955
 
dc.identifier.spage110
 
dc.identifier.urihttp://hdl.handle.net/10722/150754
 
dc.identifier.volume29
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
 
dc.publisher.placeUnited States
 
dc.relation.ispartofGenes Chromosomes and Cancer
 
dc.relation.referencesReferences in Scopus
 
dc.rightsGenes, Chromosomes & Cancer. Copyright © John Wiley & Sons, Inc.
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshCarcinoma, Hepatocellular - Genetics
 
dc.subject.meshChromosome Aberrations - Genetics
 
dc.subject.meshChromosome Deletion
 
dc.subject.meshChromosome Disorders
 
dc.subject.meshFemale
 
dc.subject.meshGene Amplification
 
dc.subject.meshHepatitis, Chronic - Genetics
 
dc.subject.meshHumans
 
dc.subject.meshIn Situ Hybridization, Fluorescence
 
dc.subject.meshInterphase - Genetics
 
dc.subject.meshLiver Neoplasms - Genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNucleic Acid Hybridization
 
dc.titleRecurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization
 
dc.typeArticle
 
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Author Affiliations
  1. National Human Genome Research Institute
  2. The University of Hong Kong
  3. Sun Yat Sen University of Medical Sciences