Article: Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization

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TitleRecurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization
AuthorsGuan, XY2
Fang, Y3
Sham, JST
Kwong, DLW
Zhang, Y3
Liang, Q3
Li, H3
Zhou, H1
Trent, JM1
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
CitationGenes Chromosomes And Cancer, 2000, v. 29 n. 2, p. 110-116 [How to Cite?]
DOI: http://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V
AbstractHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and has a very poor prognosis. Fifty primary HCC cases have been analyzed in the present study to explore the association between genomic alteration in primary HCC and clinical features. Several recurrent chromosomal abnormalities were identified in this study. The most frequently detected chromosomal gains involved chromosome arms 1q (33/50 cases, 66%), 8q (24/50 cases, 48%), and 20q (10/50 cases, 20%). High-copy-number amplifications involving lq (4 cases), 8q (3 cases), and 20q (3 cases) were detected, and a minimum overlapping amplified region at 1q12-q22 was identified. The most frequently detected loss of chromosomal material involved 16q (35/50 cases, 70%), 17p (26/50 cases, 52%), 19p (21/50 cases, 42%), 4q (20/50 cases, 40%), 1p (18/50 cases, 36%), 8p (16/50 cases, 32%), and 22q (14/50 cases, 28%). The associations between genomic alterations detected in the present study and clinical features including clinical stage, tumor size, HBV infection, chronic Fiver disease, and liver cirrhosis were explored. Our CGH results suggest that the gain of 20q and deletion of 8p are late genetic alterations in HCC, because the incidence of these alterations was obviously increased in the advanced clinical stages. Another finding showed that loss of 8p and gain of 8q and 20q are associated with tumor size. The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression. (C) 2000 Wiley-Liss, Inc.
ISSN1045-2257
2011 Impact Factor: 3.306
2011 SCImago Journal Rankings: 0.633
DOIhttp://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V
ISI Accession Number IDWOS:000089120300004
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorGuan, XY
dc.contributor.authorFang, Y
dc.contributor.authorSham, JST
dc.contributor.authorKwong, DLW
dc.contributor.authorZhang, Y
dc.contributor.authorLiang, Q
dc.contributor.authorLi, H
dc.contributor.authorZhou, H
dc.contributor.authorTrent, JM
dc.date.accessioned2012-06-26T06:09:55Z
dc.date.available2012-06-26T06:09:55Z
dc.date.issued2000
dc.description.abstractHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and has a very poor prognosis. Fifty primary HCC cases have been analyzed in the present study to explore the association between genomic alteration in primary HCC and clinical features. Several recurrent chromosomal abnormalities were identified in this study. The most frequently detected chromosomal gains involved chromosome arms 1q (33/50 cases, 66%), 8q (24/50 cases, 48%), and 20q (10/50 cases, 20%). High-copy-number amplifications involving lq (4 cases), 8q (3 cases), and 20q (3 cases) were detected, and a minimum overlapping amplified region at 1q12-q22 was identified. The most frequently detected loss of chromosomal material involved 16q (35/50 cases, 70%), 17p (26/50 cases, 52%), 19p (21/50 cases, 42%), 4q (20/50 cases, 40%), 1p (18/50 cases, 36%), 8p (16/50 cases, 32%), and 22q (14/50 cases, 28%). The associations between genomic alterations detected in the present study and clinical features including clinical stage, tumor size, HBV infection, chronic Fiver disease, and liver cirrhosis were explored. Our CGH results suggest that the gain of 20q and deletion of 8p are late genetic alterations in HCC, because the incidence of these alterations was obviously increased in the advanced clinical stages. Another finding showed that loss of 8p and gain of 8q and 20q are associated with tumor size. The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression. (C) 2000 Wiley-Liss, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationGenes Chromosomes And Cancer, 2000, v. 29 n. 2, p. 110-116 [How to Cite?]
DOI: http://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V
dc.identifier.doihttp://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V
dc.identifier.epage116
dc.identifier.hkuros61908
dc.identifier.isiWOS:000089120300004
dc.identifier.issn1045-2257
2011 Impact Factor: 3.306
2011 SCImago Journal Rankings: 0.633
dc.identifier.issue2
dc.identifier.pmid10959090
dc.identifier.scopuseid_2-s2.0-0033843955
dc.identifier.spage110
dc.identifier.urihttp://hdl.handle.net/10722/150754
dc.identifier.volume29
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
dc.publisher.placeUnited States
dc.relation.ispartofGenes Chromosomes and Cancer
dc.relation.referencesReferences in Scopus
dc.rightsGenes, Chromosomes & Cancer. Copyright © John Wiley & Sons, Inc.
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCarcinoma, Hepatocellular - Genetics
dc.subject.meshChromosome Aberrations - Genetics
dc.subject.meshChromosome Deletion
dc.subject.meshChromosome Disorders
dc.subject.meshFemale
dc.subject.meshGene Amplification
dc.subject.meshHepatitis, Chronic - Genetics
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshInterphase - Genetics
dc.subject.meshLiver Neoplasms - Genetics
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNucleic Acid Hybridization
dc.titleRecurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization
dc.typeArticle
Author Affiliations
  1. National Human Genome Research Institute
  2. The University of Hong Kong
  3. Sun Yat Sen University of Medical Sciences