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Article: The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma

TitleThe association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma
Authors
Issue Date1999
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1999, v. 59 n. 22, p. 5662-5665 How to Cite?
AbstractTo understand the genetic mechanisms underlying the progression of hepatocellular carcinoma (HCC) metastasis, differences of genomic alterations between 10 pairs of primary HCC tumors and their matched metastatic lesions were analyzed by comparative genomic hybridization. Several chromosomal alterations including loss of 8p, 4q, 17p, and 19p, gain of 5p and high-level amplification of 1q12-q22 were detected in two or more cases. The most significant finding is the loss of 8p which was detected in 8 metastatic tumors but only in 3 corresponding primary tumors (P = 0.03). This result suggests that the deletion of chromosome 8p might contribute to the development of HCC metastasis. Another interesting result is the detection of a minimum high-level amplification region at 1q12-q22 in HCC. This result provides a candidate amplification region in HCC for further study to identify amplified oncogenes related to the development or progression of HCC. Finally, this study provides a practicable model to detect specific genetic alterations related to the tumor metastasis through comparing the primary tumor and its corresponding metastatic lesion using comparative genomic hybridization technique.
Persistent Identifierhttp://hdl.handle.net/10722/150751
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQin, LXen_US
dc.contributor.authorTang, ZYen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorMa, ZCen_US
dc.contributor.authorYe, SLen_US
dc.contributor.authorZhou, XDen_US
dc.contributor.authorWu, ZQen_US
dc.contributor.authorTrent, JMen_US
dc.contributor.authorGuan, XYen_US
dc.date.accessioned2012-06-26T06:09:53Z-
dc.date.available2012-06-26T06:09:53Z-
dc.date.issued1999en_US
dc.identifier.citationCancer Research, 1999, v. 59 n. 22, p. 5662-5665en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/150751-
dc.description.abstractTo understand the genetic mechanisms underlying the progression of hepatocellular carcinoma (HCC) metastasis, differences of genomic alterations between 10 pairs of primary HCC tumors and their matched metastatic lesions were analyzed by comparative genomic hybridization. Several chromosomal alterations including loss of 8p, 4q, 17p, and 19p, gain of 5p and high-level amplification of 1q12-q22 were detected in two or more cases. The most significant finding is the loss of 8p which was detected in 8 metastatic tumors but only in 3 corresponding primary tumors (P = 0.03). This result suggests that the deletion of chromosome 8p might contribute to the development of HCC metastasis. Another interesting result is the detection of a minimum high-level amplification region at 1q12-q22 in HCC. This result provides a candidate amplification region in HCC for further study to identify amplified oncogenes related to the development or progression of HCC. Finally, this study provides a practicable model to detect specific genetic alterations related to the tumor metastasis through comparing the primary tumor and its corresponding metastatic lesion using comparative genomic hybridization technique.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Hepatocellular - Genetics - Secondaryen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human, Pair 1 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 8 - Geneticsen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleThe association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10582679-
dc.identifier.scopuseid_2-s2.0-0033571783en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033571783&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume59en_US
dc.identifier.issue22en_US
dc.identifier.spage5662en_US
dc.identifier.epage5665en_US
dc.identifier.isiWOS:000083853300005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridQin, LX=16747601200en_US
dc.identifier.scopusauthoridTang, ZY=7403306295en_US
dc.identifier.scopusauthoridSham, JST=7101655565en_US
dc.identifier.scopusauthoridMa, ZC=7403600424en_US
dc.identifier.scopusauthoridYe, SL=7202088340en_US
dc.identifier.scopusauthoridZhou, XD=7410093101en_US
dc.identifier.scopusauthoridWu, ZQ=7501414180en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US

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