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Article: L-myc genotypes in Hong Kong Chinese colorectal carcinoma patients.

TitleL-myc genotypes in Hong Kong Chinese colorectal carcinoma patients.
Authors
Issue Date1999
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 1999, v. 6 n. 2, p. 441-444 How to Cite?
AbstractL-myc genotypes have been correlated with prognosis in different human tumors. Its role in colorectal carcinoma (CRC) is still unclear. This study aimed to assess the L-myc genotypes in 99 Hong Kong Chinese CRC patients by PCR-RFLP techniques. The results obtained were correlated with clinical, histological and pathological parameters and genetic alterations. The observed frequency of L-myc genotypes (LL:LS:SS) was 27:46:26. The ratio of S to L alleles was 0.51:0.49. Distribution of L-myc genotypes and alleles in Hong Kong Chinese CRC was similar to that of healthy Chinese and CRC patients of other ethnic origins. The homozygous SS genotype was significantly associated with Dukes' stages C versus B. Other parameters including sex, differentiation status and survival, and genetic alterations such as p53 and Ki-ras mutations and Dcc LOH had no significant association with L-myc SS genotype.
Persistent Identifierhttp://hdl.handle.net/10722/150749
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKo, JMYen_US
dc.contributor.authorCheung, MHen_US
dc.contributor.authorWong, Cen_US
dc.contributor.authorLau, Ken_US
dc.contributor.authorTang, CMen_US
dc.contributor.authorKwan, MWen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:09:50Z-
dc.date.available2012-06-26T06:09:50Z-
dc.date.issued1999en_US
dc.identifier.citationOncology Reports, 1999, v. 6 n. 2, p. 441-444en_US
dc.identifier.issn1021-335Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/150749-
dc.description.abstractL-myc genotypes have been correlated with prognosis in different human tumors. Its role in colorectal carcinoma (CRC) is still unclear. This study aimed to assess the L-myc genotypes in 99 Hong Kong Chinese CRC patients by PCR-RFLP techniques. The results obtained were correlated with clinical, histological and pathological parameters and genetic alterations. The observed frequency of L-myc genotypes (LL:LS:SS) was 27:46:26. The ratio of S to L alleles was 0.51:0.49. Distribution of L-myc genotypes and alleles in Hong Kong Chinese CRC was similar to that of healthy Chinese and CRC patients of other ethnic origins. The homozygous SS genotype was significantly associated with Dukes' stages C versus B. Other parameters including sex, differentiation status and survival, and genetic alterations such as p53 and Ki-ras mutations and Dcc LOH had no significant association with L-myc SS genotype.en_US
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_US
dc.relation.ispartofOncology reportsen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshColonic Neoplasms - Genetics - Mortality - Pathologyen_US
dc.subject.meshColorectal Neoplasms - Genetics - Mortality - Pathologyen_US
dc.subject.meshDna, Neoplasm - Geneticsen_US
dc.subject.meshEthnic Groups - Geneticsen_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Mycen_US
dc.subject.meshGenes, Rasen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshJapan - Ethnologyen_US
dc.subject.meshLoss Of Heterozygosityen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshProto-Oncogene Proteins C-Myc - Geneticsen_US
dc.subject.meshRectal Neoplasms - Genetics - Mortality - Pathologyen_US
dc.subject.meshSigmoid Neoplasms - Genetics - Mortality - Pathologyen_US
dc.subject.meshSurvival Analysisen_US
dc.titleL-myc genotypes in Hong Kong Chinese colorectal carcinoma patients.en_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10023018-
dc.identifier.scopuseid_2-s2.0-0033088925en_US
dc.identifier.volume6en_US
dc.identifier.issue2en_US
dc.identifier.spage441en_US
dc.identifier.epage444en_US
dc.identifier.isiWOS:000078715900034-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridKo, JM=35725559400en_US
dc.identifier.scopusauthoridCheung, MH=37044558100en_US
dc.identifier.scopusauthoridWong, C=15745721700en_US
dc.identifier.scopusauthoridLau, K=35080643000en_US
dc.identifier.scopusauthoridTang, CM=8274797200en_US
dc.identifier.scopusauthoridKwan, MW=36860235000en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US

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