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Article: Comparative53 mutational spectra in aerodigestive tract tumors in Hong Kong Chinese patients

TitleComparative53 mutational spectra in aerodigestive tract tumors in Hong Kong Chinese patients
Authors
KeywordsAerodigestive tract cancers
Chinese
Mutations
p53
Issue Date1998
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 1998, v. 6 n. 1, p. 167-172 How to Cite?
AbstractThe p53 mutations in colorectal, esophageal and lung carcinomas from Hong Kong were studied previously. The availability of mutation data for these cancers in one geographical region prompted investigations into special features of these p53 alterations. Mutations in codons 175, 176, 248 and 273 accounted for 35% of all mutations detected. A hot spot at codon 176 observed in esophageal carcinomas was not detected in any of the other aerodigestive tract tumors studied and appeared to be uniquely restricted to Chinese esophageal cancers. Other unique mutation sites, and a notably higher frequency of insertions and deletions in each of these cancers. were also detected in Chinese patients as compared to Caucasians.
Persistent Identifierhttp://hdl.handle.net/10722/150743
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, WCen_HK
dc.contributor.authorLeung, CSen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2012-06-26T06:09:38Z-
dc.date.available2012-06-26T06:09:38Z-
dc.date.issued1998en_HK
dc.identifier.citationOncology Reports, 1998, v. 6 n. 1, p. 167-172en_HK
dc.identifier.issn1021-335Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/150743-
dc.description.abstractThe p53 mutations in colorectal, esophageal and lung carcinomas from Hong Kong were studied previously. The availability of mutation data for these cancers in one geographical region prompted investigations into special features of these p53 alterations. Mutations in codons 175, 176, 248 and 273 accounted for 35% of all mutations detected. A hot spot at codon 176 observed in esophageal carcinomas was not detected in any of the other aerodigestive tract tumors studied and appeared to be uniquely restricted to Chinese esophageal cancers. Other unique mutation sites, and a notably higher frequency of insertions and deletions in each of these cancers. were also detected in Chinese patients as compared to Caucasians.en_HK
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_HK
dc.relation.ispartofOncology Reportsen_HK
dc.subjectAerodigestive tract cancersen_HK
dc.subjectChineseen_HK
dc.subjectMutationsen_HK
dc.subjectp53en_HK
dc.titleComparative53 mutational spectra in aerodigestive tract tumors in Hong Kong Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailLung, ML: mlilung@hku.hken_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9864422-
dc.identifier.scopuseid_2-s2.0-0032615592en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032615592&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue1en_HK
dc.identifier.spage167en_HK
dc.identifier.epage172en_HK
dc.identifier.isiWOS:000077665900030-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridChan, WC=55471368200en_HK
dc.identifier.scopusauthoridLeung, CS=7402612613en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK

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