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Article: Selective induction of tumor necrosis factor receptor type II gene expression by tumor necrosis factor-α in C6 glioma cells

TitleSelective induction of tumor necrosis factor receptor type II gene expression by tumor necrosis factor-α in C6 glioma cells
Authors
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1998, v. 62 n. 10, p. 889-896 How to Cite?
AbstractUsing reverse transcription-polymerase chain reaction (RT-PCR) technique, the levels of tumor necrosis factor receptors gene expression in C6 glioma cells upon induction with tumor necrosis factor-alpha (TNF-α) were analysed. In control cells, the level of mRNA for tumor necrosis factor receptor type II (TNF-R2; 75/80 kDa) was much lower than that of tumor necrosis factor receptor type I (TNF-R1; 55/60 kDa). Upon exposure to TNF-α, the TNF-R2 mRNA level was greatly increased, while the TNF-R1 mRNA level remained unchanged even after 48 h. The induction of TNF-R2 gene expression by TNF-α was dose-dependent and seemed to be unique to TNF-α, as IL-6 had no effect. Since TNF-R2 was reported to mediate mitogenic effect in many other cell types, it is likely that the reported proliferative effect of TNF-α on astrocytes and C6 glioma cells was mediated by this TNF receptor subtype.
Persistent Identifierhttp://hdl.handle.net/10722/150742
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, Hen_US
dc.contributor.authorLung, HLen_US
dc.contributor.authorLeung, KNen_US
dc.contributor.authorTsang, Den_US
dc.date.accessioned2012-06-26T06:09:37Z-
dc.date.available2012-06-26T06:09:37Z-
dc.date.issued1998en_US
dc.identifier.citationLife Sciences, 1998, v. 62 n. 10, p. 889-896en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/150742-
dc.description.abstractUsing reverse transcription-polymerase chain reaction (RT-PCR) technique, the levels of tumor necrosis factor receptors gene expression in C6 glioma cells upon induction with tumor necrosis factor-alpha (TNF-α) were analysed. In control cells, the level of mRNA for tumor necrosis factor receptor type II (TNF-R2; 75/80 kDa) was much lower than that of tumor necrosis factor receptor type I (TNF-R1; 55/60 kDa). Upon exposure to TNF-α, the TNF-R2 mRNA level was greatly increased, while the TNF-R1 mRNA level remained unchanged even after 48 h. The induction of TNF-R2 gene expression by TNF-α was dose-dependent and seemed to be unique to TNF-α, as IL-6 had no effect. Since TNF-R2 was reported to mediate mitogenic effect in many other cell types, it is likely that the reported proliferative effect of TNF-α on astrocytes and C6 glioma cells was mediated by this TNF receptor subtype.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.subject.meshActins - Geneticsen_US
dc.subject.meshAntigens, Cd - Geneticsen_US
dc.subject.meshBrain Neoplasms - Genetics - Pathologyen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshGlioma - Genetics - Pathologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshRna, Messenger - Genetics - Metabolismen_US
dc.subject.meshReceptors, Tumor Necrosis Factor - Geneticsen_US
dc.subject.meshReceptors, Tumor Necrosis Factor, Type Ien_US
dc.subject.meshReceptors, Tumor Necrosis Factor, Type Iien_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshTumor Necrosis Factor-Alpha - Pharmacologyen_US
dc.titleSelective induction of tumor necrosis factor receptor type II gene expression by tumor necrosis factor-α in C6 glioma cellsen_US
dc.typeArticleen_US
dc.identifier.emailLung, HL:hllung2@hku.hken_US
dc.identifier.authorityLung, HL=rp00299en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0024-3205(98)00006-Xen_US
dc.identifier.pmid9496711-
dc.identifier.scopuseid_2-s2.0-0032579546en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032579546&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.issue10en_US
dc.identifier.spage889en_US
dc.identifier.epage896en_US
dc.identifier.isiWOS:000071947000005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHuang, H=23097669500en_US
dc.identifier.scopusauthoridLung, HL=6603819904en_US
dc.identifier.scopusauthoridLeung, KN=7401860476en_US
dc.identifier.scopusauthoridTsang, D=7005609135en_US

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