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Article: Ki-ras codon 12 point mutational activation in Hong Kong colorectal carcinoma patients

TitleKi-ras codon 12 point mutational activation in Hong Kong colorectal carcinoma patients
Authors
Ko, JMYCheung, MHYWong, CMLau, KWTang, CMCKwan, MWLung, ML
KeywordsColorectal cancer
Ki-ras
Mutation
Issue Date1998
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 1998, v. 134 n. 2, p. 169-176 How to Cite?
DOI: http://dx.doi.org/10.1016/S0304-3835(98)00257-2
AbstractThis study investigated the frequency and importance of Ki-ras codon 12 mutations in 99 Hong Kong Chinese colorectal carcinoma specimens by allele-specific oligonucleotide hybridization. The frequency of mutations detected was 30% and the most common mutation observed resulted in aspartic acid substitutions. Previous studies showed that specific Ki-ras mutations have been significantly associated with prognosis. Ki-ras codon 12 point mutational activation in CRC was significantly associated with the differentiation status of tumors in this study. Ethnic differences in the patterns of Ki-ras codon 12 point mutations were observed. Copyright (C) 1998 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/150740
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
ISI Accession Number ID
WOS:000077949600007
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorKo, JMYen_US
dc.contributor.authorCheung, MHYen_US
dc.contributor.authorWong, CMen_US
dc.contributor.authorLau, KWen_US
dc.contributor.authorTang, CMCen_US
dc.contributor.authorKwan, MWen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:09:36Z-
dc.date.available2012-06-26T06:09:36Z-
dc.date.issued1998en_US
dc.identifier.citationCancer Letters, 1998, v. 134 n. 2, p. 169-176en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/150740-
dc.description.abstractThis study investigated the frequency and importance of Ki-ras codon 12 mutations in 99 Hong Kong Chinese colorectal carcinoma specimens by allele-specific oligonucleotide hybridization. The frequency of mutations detected was 30% and the most common mutation observed resulted in aspartic acid substitutions. Previous studies showed that specific Ki-ras mutations have been significantly associated with prognosis. Ki-ras codon 12 point mutational activation in CRC was significantly associated with the differentiation status of tumors in this study. Ethnic differences in the patterns of Ki-ras codon 12 point mutations were observed. Copyright (C) 1998 Elsevier Science Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subjectColorectal cancer-
dc.subjectKi-ras-
dc.subjectMutation-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCarcinoma - Genetics - Pathologyen_US
dc.subject.meshCodon - Geneticsen_US
dc.subject.meshColorectal Neoplasms - Genetics - Pathologyen_US
dc.subject.meshDna Primersen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshGenes, P53 - Geneticsen_US
dc.subject.meshGenes, Ras - Geneticsen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPoint Mutationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleKi-ras codon 12 point mutational activation in Hong Kong colorectal carcinoma patientsen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3835(98)00257-2en_US
dc.identifier.pmid10025877-
dc.identifier.scopuseid_2-s2.0-0032438455en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032438455&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume134en_US
dc.identifier.issue2en_US
dc.identifier.spage169en_US
dc.identifier.epage176en_US
dc.identifier.isiWOS:000077949600007-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridKo, JMY=35725559400en_US
dc.identifier.scopusauthoridCheung, MHY=37044558100en_US
dc.identifier.scopusauthoridWong, CM=36631357000en_US
dc.identifier.scopusauthoridLau, KW=35080643000en_US
dc.identifier.scopusauthoridTang, CMC=8274797200en_US
dc.identifier.scopusauthoridKwan, MW=36860235000en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.issnl0304-3835-

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