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Article: Detection of chromosome 6 abnormalities in melanoma cell lines by chromosome arm painting probes

TitleDetection of chromosome 6 abnormalities in melanoma cell lines by chromosome arm painting probes
Authors
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1998, v. 107 n. 2, p. 89-92 How to Cite?
AbstractChromosome 6 abnormalities, particularly the deletion of 6q, are among the mast frequent chromosomal changes in human malignant melonama. In this study, chromosome 6 rearrangements in 21 melanoma cell lines were identified by fluorescence in situ hybridization (FISH) with the use of chromosome 6 arm specific painting probes (CAPs). Structural abnormalities of chromosome 6 were detectable in 18 of 21 (86%) cases, including the identification of structural abnormalities that were not detectable by routine G-banding analysis. The results of this study correlate the frequency of 6q alterations and demonstrate that FISH with CAPs can be of considerable use for rapid screening of specific chromosome abnormalities in melanoma.
Persistent Identifierhttp://hdl.handle.net/10722/150739
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, XYen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorYang, JMen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorTaetle, Ren_US
dc.contributor.authorMeltzer, PSen_US
dc.contributor.authorTrent, JMen_US
dc.date.accessioned2012-06-26T06:09:30Z-
dc.date.available2012-06-26T06:09:30Z-
dc.date.issued1998en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1998, v. 107 n. 2, p. 89-92en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/150739-
dc.description.abstractChromosome 6 abnormalities, particularly the deletion of 6q, are among the mast frequent chromosomal changes in human malignant melonama. In this study, chromosome 6 rearrangements in 21 melanoma cell lines were identified by fluorescence in situ hybridization (FISH) with the use of chromosome 6 arm specific painting probes (CAPs). Structural abnormalities of chromosome 6 were detectable in 18 of 21 (86%) cases, including the identification of structural abnormalities that were not detectable by routine G-banding analysis. The results of this study correlate the frequency of 6q alterations and demonstrate that FISH with CAPs can be of considerable use for rapid screening of specific chromosome abnormalities in melanoma.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshChromosome Aberrations - Diagnosisen_US
dc.subject.meshChromosome Disordersen_US
dc.subject.meshChromosome Painting - Methodsen_US
dc.subject.meshChromosomes, Human, Pair 6 - Geneticsen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHumansen_US
dc.subject.meshMelanoma - Geneticsen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleDetection of chromosome 6 abnormalities in melanoma cell lines by chromosome arm painting probesen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(98)00080-6en_US
dc.identifier.pmid9844599-
dc.identifier.scopuseid_2-s2.0-0032401956en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032401956&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume107en_US
dc.identifier.issue2en_US
dc.identifier.spage89en_US
dc.identifier.epage92en_US
dc.identifier.isiWOS:000077167200001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridZhang, H=7409194743en_US
dc.identifier.scopusauthoridYang, JM=12445064900en_US
dc.identifier.scopusauthoridWang, J=37036679800en_US
dc.identifier.scopusauthoridTaetle, R=7006711648en_US
dc.identifier.scopusauthoridMeltzer, PS=7102464641en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US

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