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Article: Zoo-FISH with microdissected arm specific paints for HSA2, 5, 6, 16, and 19 refines known homology with pig and horse chromosomes

TitleZoo-FISH with microdissected arm specific paints for HSA2, 5, 6, 16, and 19 refines known homology with pig and horse chromosomes
Authors
Issue Date1998
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/
Citation
Mammalian Genome, 1998, v. 9 n. 1, p. 44-49 How to Cite?
AbstractMicrodissected arm specific paints (ASPs) for human (HSA) chromosomes (Chrs) 2, 5, 6, 16, and 19 were used as probes on pig (SSC) and horse (ECA) metaphase chromosomes. Regions homologous to individual human arms were delineated in the two species studied. Of the ten ASPs used, HSA6 and 16 ASPs showed complete synteny conservation of individual arms as single blocks/arms both in pig and home. A similar trend was, in general, also observed for HSA19 ASPs. However, contrary to these observations, synteny conservation of individual arms of HSA2 and HSA5 was not observed in pig and horse. The arm specific painting data, coupled with the available gene mapping data, showed that, although HSA2 corresponded to two arms/chromosomes each in pig and horse, the breakpoint of this synteny in humans was not located at the centromere, but at HSA2q13 band. Similarly, arm specific paints for HSA5 showed that of the two blocks/chromosomes painted in pig and horse, one corresponded to HSA5q13-pter, the other to HSA5q13-qter. The findings suggest that 5q13 band may also be an evolutionary break point, similar to the one detected on HSA2q13. The microdissected human arm specific painting probes used in the present work provide more accurate and refined comparative information on pig and horse chromosomes than that available through the use of human whole chromosome specific paints.
Persistent Identifierhttp://hdl.handle.net/10722/150738
ISSN
2015 Impact Factor: 2.078
2015 SCImago Journal Rankings: 2.082
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChaudhary, Ren_US
dc.contributor.authorRaudsepp, Ten_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorChowdhary, BPen_US
dc.date.accessioned2012-06-26T06:09:28Z-
dc.date.available2012-06-26T06:09:28Z-
dc.date.issued1998en_US
dc.identifier.citationMammalian Genome, 1998, v. 9 n. 1, p. 44-49en_US
dc.identifier.issn0938-8990en_US
dc.identifier.urihttp://hdl.handle.net/10722/150738-
dc.description.abstractMicrodissected arm specific paints (ASPs) for human (HSA) chromosomes (Chrs) 2, 5, 6, 16, and 19 were used as probes on pig (SSC) and horse (ECA) metaphase chromosomes. Regions homologous to individual human arms were delineated in the two species studied. Of the ten ASPs used, HSA6 and 16 ASPs showed complete synteny conservation of individual arms as single blocks/arms both in pig and home. A similar trend was, in general, also observed for HSA19 ASPs. However, contrary to these observations, synteny conservation of individual arms of HSA2 and HSA5 was not observed in pig and horse. The arm specific painting data, coupled with the available gene mapping data, showed that, although HSA2 corresponded to two arms/chromosomes each in pig and horse, the breakpoint of this synteny in humans was not located at the centromere, but at HSA2q13 band. Similarly, arm specific paints for HSA5 showed that of the two blocks/chromosomes painted in pig and horse, one corresponded to HSA5q13-pter, the other to HSA5q13-qter. The findings suggest that 5q13 band may also be an evolutionary break point, similar to the one detected on HSA2q13. The microdissected human arm specific painting probes used in the present work provide more accurate and refined comparative information on pig and horse chromosomes than that available through the use of human whole chromosome specific paints.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/en_US
dc.relation.ispartofMammalian Genomeen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChromosomes, Human, Pair 16en_US
dc.subject.meshChromosomes, Human, Pair 19en_US
dc.subject.meshChromosomes, Human, Pair 2en_US
dc.subject.meshChromosomes, Human, Pair 5en_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshHorses - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescence - Methodsen_US
dc.subject.meshSwine - Geneticsen_US
dc.titleZoo-FISH with microdissected arm specific paints for HSA2, 5, 6, 16, and 19 refines known homology with pig and horse chromosomesen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s003359900677en_US
dc.identifier.pmid9434944-
dc.identifier.scopuseid_2-s2.0-0031944658en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031944658&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume9en_US
dc.identifier.issue1en_US
dc.identifier.spage44en_US
dc.identifier.epage49en_US
dc.identifier.isiWOS:000071219500009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChaudhary, R=7102392882en_US
dc.identifier.scopusauthoridRaudsepp, T=6603846859en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridZhang, H=7409194743en_US
dc.identifier.scopusauthoridChowdhary, BP=7006769243en_US

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