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Article: Retropharyngeal lymphadenopathy in patients with nasopharyngeal carcinoma: A computed tomography-based study

TitleRetropharyngeal lymphadenopathy in patients with nasopharyngeal carcinoma: A computed tomography-based study
Authors
Keywordscervical metastases
computed tomography
nasopharyngeal carcinoma
retropharyngeal lymph node
Issue Date1997
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1997, v. 79 n. 5, p. 869-877 How to Cite?
AbstractBACKGROUND. The purpose of this study was to investigate the incidence and prognostic value of retropharyngeal lymphadenopathy in nasopharyngeal carcinoma patients using contrast enhanced computed tomography (CT). METHODS. From January 1989 to December 1991, 364 patients with newly diagnosed nasopharyngeal carcinoma without distant metastasis had a baseline CT performed. All patients had radiotherapy as their primary treatment. Eighty- seven patients also received neoadjuvant chemotherapy for locally advanced disease. All patients with clinical N0 disease had prophylactic lymph node irradiation. The contrast enhanced CT given prior to all treatment was evaluated for the presence of retropharyngeal lymphadenopathy. Criteria for involved lymph nodes included a lymph node size of 10 mm or more, the presence of central necrosis within the lymph node, or the presence of a contrast enhancing rim. RESULTS. The incidence of retropharyngeal lymphadenopathy was 29.1%. A higher incidence of retropharyngeal lymph node involvement was observed in Ho's T2/T3 disease compared with T1 disease, and a higher incidence was also found in patients with cervical lymph node disease compared with those with clinical N0 disease. No significant differences in relapse free survival rates, local control rates, lymph node control rates, or distant failure rates were observed between patients with or without retropharyngeal lymphadenopathy after adjusting for T and N classifications. In 134 patients with clinical N0 disease, retropharyngeal lymphadenopathy was found in 21 patients, whereas 113 had no evidence of retropharyngeal lymphadenopathy. However, no significant difference in treatment outcome was observed between the two groups. CONCLUSIONS. Using CT imaging, the presence of retropharyngeal lymphadenopathy in patients with nasopharyngeal carcinoma does not appear to affect the prognosis. In patients with clinical N0 disease, the identification of retropharyngeal lymphadenopathy based only on CT imaging is not sufficient evidence for an N1 classification.
Persistent Identifierhttp://hdl.handle.net/10722/150735
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorAu, GKHen_HK
dc.contributor.authorChoy, DTKen_HK
dc.date.accessioned2012-06-26T06:09:24Z-
dc.date.available2012-06-26T06:09:24Z-
dc.date.issued1997en_HK
dc.identifier.citationCancer, 1997, v. 79 n. 5, p. 869-877en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/150735-
dc.description.abstractBACKGROUND. The purpose of this study was to investigate the incidence and prognostic value of retropharyngeal lymphadenopathy in nasopharyngeal carcinoma patients using contrast enhanced computed tomography (CT). METHODS. From January 1989 to December 1991, 364 patients with newly diagnosed nasopharyngeal carcinoma without distant metastasis had a baseline CT performed. All patients had radiotherapy as their primary treatment. Eighty- seven patients also received neoadjuvant chemotherapy for locally advanced disease. All patients with clinical N0 disease had prophylactic lymph node irradiation. The contrast enhanced CT given prior to all treatment was evaluated for the presence of retropharyngeal lymphadenopathy. Criteria for involved lymph nodes included a lymph node size of 10 mm or more, the presence of central necrosis within the lymph node, or the presence of a contrast enhancing rim. RESULTS. The incidence of retropharyngeal lymphadenopathy was 29.1%. A higher incidence of retropharyngeal lymph node involvement was observed in Ho's T2/T3 disease compared with T1 disease, and a higher incidence was also found in patients with cervical lymph node disease compared with those with clinical N0 disease. No significant differences in relapse free survival rates, local control rates, lymph node control rates, or distant failure rates were observed between patients with or without retropharyngeal lymphadenopathy after adjusting for T and N classifications. In 134 patients with clinical N0 disease, retropharyngeal lymphadenopathy was found in 21 patients, whereas 113 had no evidence of retropharyngeal lymphadenopathy. However, no significant difference in treatment outcome was observed between the two groups. CONCLUSIONS. Using CT imaging, the presence of retropharyngeal lymphadenopathy in patients with nasopharyngeal carcinoma does not appear to affect the prognosis. In patients with clinical N0 disease, the identification of retropharyngeal lymphadenopathy based only on CT imaging is not sufficient evidence for an N1 classification.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.subjectcervical metastasesen_HK
dc.subjectcomputed tomographyen_HK
dc.subjectnasopharyngeal carcinomaen_HK
dc.subjectretropharyngeal lymph nodeen_HK
dc.subject.meshCarcinoma - Pathology - Radiography - Therapyen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoblastic Lymphadenopathy - Epidemiology - Pathology - Radiography - Therapyen_US
dc.subject.meshLymph Nodes - Pathology - Radiographyen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshNasopharyngeal Neoplasms - Pathology - Radiography - Therapyen_US
dc.subject.meshPharynxen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleRetropharyngeal lymphadenopathy in patients with nasopharyngeal carcinoma: A computed tomography-based studyen_HK
dc.typeArticleen_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0142(19970301)79:5<869::AID-CNCR1>3.0.CO;2-7en_HK
dc.identifier.pmid9041147-
dc.identifier.scopuseid_2-s2.0-0031053974en_HK
dc.identifier.hkuros27656-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031053974&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume79en_HK
dc.identifier.issue5en_HK
dc.identifier.spage869en_HK
dc.identifier.epage877en_HK
dc.identifier.isiWOS:A1997WJ66700001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridAu, GKH=7003748615en_HK
dc.identifier.scopusauthoridChoy, DTK=7102939127en_HK

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