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Article: Tumor control probability of nasopharyngeal carcinoma: A comparison of different mathematical models

TitleTumor control probability of nasopharyngeal carcinoma: A comparison of different mathematical models
Authors
KeywordsNasopharyngeal carcinoma
Radiation dose
Tumor control probability
Tumor volume
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal of Radiation Oncology - Biology - Physics, 1997, v. 37 n. 4, p. 913-920 How to Cite?
AbstractPurpose: Radiation dose and tumor volume are factors known to affect the local control of a given type of tumor. Local tumor control is a major factor to consider when a treatment plan is evaluated. This article reports the correlation between tumor control probability, dose, and volume in a retrospective study of 142 patients with nasopharyngeal carcinoma (NPC). Methods and Materials: The tumor volume was outlined and calculated from a computed tomographic scan. Patients were categorized according to tumor volume and radiation dose received in treatment. Local control rate was calculated for each category by the Kaplan-Meier method. Mathematical models were fitted to correlate the local control rate, dose, and volume. Both empirical and mechanistic approaches were attempted; the former included logistic models with two and three parameters, and the latter, the formulation from Brenner and Bentzen with a radiobiological basis. Results: Brenner's model estimated α at 0.041Gy -1 with 95% confidence limits (- 0.032, 0.113) Gy -1. The volume dependent constant h was estimated at 0.160 cm -3 with 95% confidence limits (-0.729, 1.048) cm -3. The Pearson correlation coefficient was 0.64. The magnitude and sign of the fitted parameters were reasonable and consistent with reported clinical experience. The other models were fitted with slightly better goodness of fit (r = 0.65 - 0.68), but with less interpretable parameters. Conclusion: Brenner's model is considered appropriate for a description of the dose and volume effect on the local control of the NPC. It could be used in combination with normal tissue complication probability for treatment plan evaluation to optimize treatment results.
Persistent Identifierhttp://hdl.handle.net/10722/150733
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, PMen_HK
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorLeung, Len_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorLo, Men_HK
dc.contributor.authorYung, Aen_HK
dc.contributor.authorChoy, DTKen_HK
dc.date.accessioned2012-06-26T06:09:23Z-
dc.date.available2012-06-26T06:09:23Z-
dc.date.issued1997en_HK
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 1997, v. 37 n. 4, p. 913-920en_HK
dc.identifier.issn0360-3016en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150733-
dc.description.abstractPurpose: Radiation dose and tumor volume are factors known to affect the local control of a given type of tumor. Local tumor control is a major factor to consider when a treatment plan is evaluated. This article reports the correlation between tumor control probability, dose, and volume in a retrospective study of 142 patients with nasopharyngeal carcinoma (NPC). Methods and Materials: The tumor volume was outlined and calculated from a computed tomographic scan. Patients were categorized according to tumor volume and radiation dose received in treatment. Local control rate was calculated for each category by the Kaplan-Meier method. Mathematical models were fitted to correlate the local control rate, dose, and volume. Both empirical and mechanistic approaches were attempted; the former included logistic models with two and three parameters, and the latter, the formulation from Brenner and Bentzen with a radiobiological basis. Results: Brenner's model estimated α at 0.041Gy -1 with 95% confidence limits (- 0.032, 0.113) Gy -1. The volume dependent constant h was estimated at 0.160 cm -3 with 95% confidence limits (-0.729, 1.048) cm -3. The Pearson correlation coefficient was 0.64. The magnitude and sign of the fitted parameters were reasonable and consistent with reported clinical experience. The other models were fitted with slightly better goodness of fit (r = 0.65 - 0.68), but with less interpretable parameters. Conclusion: Brenner's model is considered appropriate for a description of the dose and volume effect on the local control of the NPC. It could be used in combination with normal tissue complication probability for treatment plan evaluation to optimize treatment results.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobpen_HK
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectRadiation doseen_HK
dc.subjectTumor control probabilityen_HK
dc.subjectTumor volumeen_HK
dc.subject.meshAdulten_US
dc.subject.meshCarcinoma - Pathology - Radiotherapyen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Theoreticalen_US
dc.subject.meshNasopharyngeal Neoplasms - Pathology - Radiotherapyen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshProbabilityen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleTumor control probability of nasopharyngeal carcinoma: A comparison of different mathematical modelsen_HK
dc.typeArticleen_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0360-3016(96)00588-3en_HK
dc.identifier.pmid9128969en_HK
dc.identifier.scopuseid_2-s2.0-0030978533en_HK
dc.identifier.hkuros27642-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030978533&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue4en_HK
dc.identifier.spage913en_HK
dc.identifier.epage920en_HK
dc.identifier.isiWOS:A1997WW11800024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, PM=8663653900en_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridLeung, L=7202048113en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridLo, M=7101897477en_HK
dc.identifier.scopusauthoridYung, A=17837027200en_HK
dc.identifier.scopusauthoridChoy, DTK=7102939127en_HK

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