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Article: p16 tumor suppressor gene mutations in Chinese esophageal carcinomas in Hong Kong

Titlep16 tumor suppressor gene mutations in Chinese esophageal carcinomas in Hong Kong
Authors
KeywordsEsophageal cancer
Mutation
p16 gene
Issue Date1997
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 1997, v. 115 n. 2, p. 201-206 How to Cite?
AbstractThe frequency and nature of genetic alterations in the p16 tumor suppressor gene in 25 esophageal squamous cell carcinoma specimens from Chinese patients were investigated by PCR-SSCP and DNA sequencing techniques. No gross deletions occurred in either exon 1 and 2 of the gene by PCR amplification. However, genetic changes were observed in three cases. These included a point mutation in codon 12 of exon 1 with a resulting Ala → Thr amino acid substitution, a point mutation at base 91 in the non-coding region of exon 1, and a 1 base pair insertion in codon 116 of exon 2. The low mutation frequency of 12% is consistent with that of three previous studies involving Japanese and Caucasian patients (8, 16 and 21% frequency). p16 gene mutations do not appear to play a major role in esophageal carcinogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/150730
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, WCen_HK
dc.contributor.authorTang, CMCen_HK
dc.contributor.authorLau, KWen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2012-06-26T06:09:20Z-
dc.date.available2012-06-26T06:09:20Z-
dc.date.issued1997en_HK
dc.identifier.citationCancer Letters, 1997, v. 115 n. 2, p. 201-206en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150730-
dc.description.abstractThe frequency and nature of genetic alterations in the p16 tumor suppressor gene in 25 esophageal squamous cell carcinoma specimens from Chinese patients were investigated by PCR-SSCP and DNA sequencing techniques. No gross deletions occurred in either exon 1 and 2 of the gene by PCR amplification. However, genetic changes were observed in three cases. These included a point mutation in codon 12 of exon 1 with a resulting Ala → Thr amino acid substitution, a point mutation at base 91 in the non-coding region of exon 1, and a 1 base pair insertion in codon 116 of exon 2. The low mutation frequency of 12% is consistent with that of three previous studies involving Japanese and Caucasian patients (8, 16 and 21% frequency). p16 gene mutations do not appear to play a major role in esophageal carcinogenesis.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.subjectEsophageal canceren_HK
dc.subjectMutationen_HK
dc.subjectp16 geneen_HK
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshCarrier Proteins - Geneticsen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshCyclin-Dependent Kinase Inhibitor P16en_US
dc.subject.meshDna, Neoplasm - Analysis - Geneticsen_US
dc.subject.meshEsophageal Neoplasms - Geneticsen_US
dc.subject.meshExonsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPoint Mutationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_US
dc.titlep16 tumor suppressor gene mutations in Chinese esophageal carcinomas in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailLung, ML: mlilung@hku.hken_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3835(97)04748-4en_HK
dc.identifier.pmid9149125-
dc.identifier.scopuseid_2-s2.0-0030897676en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030897676&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume115en_HK
dc.identifier.issue2en_HK
dc.identifier.spage201en_HK
dc.identifier.epage206en_HK
dc.identifier.isiWOS:A1997WW33200011-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridChan, WC=55471368200en_HK
dc.identifier.scopusauthoridTang, CMC=8274797200en_HK
dc.identifier.scopusauthoridLau, KW=35080643000en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK

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