Article: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

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TitleAIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
AuthorsAnzick, SL1
Kononen, J1
Walker, RL1
Azorsa, DO1
Tanner, MM3
Guan, XY1
Sauter, G2
Kallioniemi, OP1
Trent, JM1
Meltzer, PS1
Issue Date1997
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
CitationScience, 1997, v. 277 n. 5328, p. 965-968 [How to Cite?]
DOI: http://dx.doi.org/10.1126/science.277.5328.965
AbstractMembers of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand- dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen- dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.
ISSN0036-8075
2011 Impact Factor: 31.201
2011 SCImago Journal Rankings: 5.425
DOIhttp://dx.doi.org/10.1126/science.277.5328.965
ISI Accession Number IDWOS:A1997XQ98500044
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorAnzick, SL
dc.contributor.authorKononen, J
dc.contributor.authorWalker, RL
dc.contributor.authorAzorsa, DO
dc.contributor.authorTanner, MM
dc.contributor.authorGuan, XY
dc.contributor.authorSauter, G
dc.contributor.authorKallioniemi, OP
dc.contributor.authorTrent, JM
dc.contributor.authorMeltzer, PS
dc.date.accessioned2012-06-26T06:09:18Z
dc.date.available2012-06-26T06:09:18Z
dc.date.issued1997
dc.description.abstractMembers of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand- dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen- dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationScience, 1997, v. 277 n. 5328, p. 965-968 [How to Cite?]
DOI: http://dx.doi.org/10.1126/science.277.5328.965
dc.identifier.doihttp://dx.doi.org/10.1126/science.277.5328.965
dc.identifier.epage968
dc.identifier.isiWOS:A1997XQ98500044
dc.identifier.issn0036-8075
2011 Impact Factor: 31.201
2011 SCImago Journal Rankings: 5.425
dc.identifier.issue5328
dc.identifier.pmid9252329
dc.identifier.scopuseid_2-s2.0-0030797902
dc.identifier.spage965
dc.identifier.urihttp://hdl.handle.net/10722/150728
dc.identifier.volume277
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
dc.publisher.placeUnited States
dc.relation.ispartofScience
dc.relation.referencesReferences in Scopus
dc.subject.meshAmino Acid Sequence
dc.subject.meshBreast - Metabolism
dc.subject.meshBreast Neoplasms - Genetics - Metabolism
dc.subject.meshChromosomes, Human, Pair 20
dc.subject.meshCloning, Molecular
dc.subject.meshEstradiol - Metabolism - Pharmacology
dc.subject.meshFemale
dc.subject.meshGene Amplification
dc.subject.meshGene Dosage
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshHistone Acetyltransferases
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshLigands
dc.subject.meshMolecular Sequence Data
dc.subject.meshNeoplasms, Hormone-Dependent - Genetics - Metabolism
dc.subject.meshNuclear Receptor Coactivator 1
dc.subject.meshNuclear Receptor Coactivator 2
dc.subject.meshOvarian Neoplasms - Genetics - Metabolism
dc.subject.meshReceptors, Estrogen - Genetics - Metabolism
dc.subject.meshTranscription Factors - Genetics
dc.subject.meshTranscriptional Activation
dc.subject.meshTransfection
dc.subject.meshTumor Cells, Cultured
dc.titleAIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
dc.typeArticle
Author Affiliations
  1. National Human Genome Research Institute
  2. Universitätsspital Basel Institute of Pathology
  3. University Hospital of Tampere