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Article: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
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TitleAIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
 
AuthorsAnzick, SL1
Kononen, J1
Walker, RL1
Azorsa, DO1
Tanner, MM3
Guan, XY1
Sauter, G2
Kallioniemi, OP1
Trent, JM1
Meltzer, PS1
 
Issue Date1997
 
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
 
CitationScience, 1997, v. 277 n. 5328, p. 965-968 [How to Cite?]
DOI: http://dx.doi.org/10.1126/science.277.5328.965
 
AbstractMembers of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand- dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen- dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.
 
ISSN0036-8075
2012 Impact Factor: 31.027
2012 SCImago Journal Rankings: 10.618
 
DOIhttp://dx.doi.org/10.1126/science.277.5328.965
 
ISI Accession Number IDWOS:A1997XQ98500044
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorAnzick, SL
 
dc.contributor.authorKononen, J
 
dc.contributor.authorWalker, RL
 
dc.contributor.authorAzorsa, DO
 
dc.contributor.authorTanner, MM
 
dc.contributor.authorGuan, XY
 
dc.contributor.authorSauter, G
 
dc.contributor.authorKallioniemi, OP
 
dc.contributor.authorTrent, JM
 
dc.contributor.authorMeltzer, PS
 
dc.date.accessioned2012-06-26T06:09:18Z
 
dc.date.available2012-06-26T06:09:18Z
 
dc.date.issued1997
 
dc.description.abstractMembers of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand- dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen- dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationScience, 1997, v. 277 n. 5328, p. 965-968 [How to Cite?]
DOI: http://dx.doi.org/10.1126/science.277.5328.965
 
dc.identifier.doihttp://dx.doi.org/10.1126/science.277.5328.965
 
dc.identifier.epage968
 
dc.identifier.isiWOS:A1997XQ98500044
 
dc.identifier.issn0036-8075
2012 Impact Factor: 31.027
2012 SCImago Journal Rankings: 10.618
 
dc.identifier.issue5328
 
dc.identifier.pmid9252329
 
dc.identifier.scopuseid_2-s2.0-0030797902
 
dc.identifier.spage965
 
dc.identifier.urihttp://hdl.handle.net/10722/150728
 
dc.identifier.volume277
 
dc.languageeng
 
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofScience
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAmino Acid Sequence
 
dc.subject.meshBreast - Metabolism
 
dc.subject.meshBreast Neoplasms - Genetics - Metabolism
 
dc.subject.meshChromosomes, Human, Pair 20
 
dc.subject.meshCloning, Molecular
 
dc.subject.meshEstradiol - Metabolism - Pharmacology
 
dc.subject.meshFemale
 
dc.subject.meshGene Amplification
 
dc.subject.meshGene Dosage
 
dc.subject.meshGene Expression Regulation, Neoplastic
 
dc.subject.meshHistone Acetyltransferases
 
dc.subject.meshHumans
 
dc.subject.meshIn Situ Hybridization, Fluorescence
 
dc.subject.meshLigands
 
dc.subject.meshMolecular Sequence Data
 
dc.subject.meshNeoplasms, Hormone-Dependent - Genetics - Metabolism
 
dc.subject.meshNuclear Receptor Coactivator 1
 
dc.subject.meshNuclear Receptor Coactivator 2
 
dc.subject.meshOvarian Neoplasms - Genetics - Metabolism
 
dc.subject.meshReceptors, Estrogen - Genetics - Metabolism
 
dc.subject.meshTranscription Factors - Genetics
 
dc.subject.meshTranscriptional Activation
 
dc.subject.meshTransfection
 
dc.subject.meshTumor Cells, Cultured
 
dc.titleAIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
 
dc.typeArticle
 
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<contributor.author>Sauter, G</contributor.author>
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Author Affiliations
  1. National Human Genome Research Institute
  2. Universitätsspital Basel Institute of Pathology
  3. University Hospital of Tampere