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Article: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

TitleAIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
Authors
Issue Date1997
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 1997, v. 277 n. 5328, p. 965-968 How to Cite?
Abstract
Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand- dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen- dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.
Persistent Identifierhttp://hdl.handle.net/10722/150728
ISSN
2013 Impact Factor: 31.477
2013 SCImago Journal Rankings: 12.465
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnzick, SLen_US
dc.contributor.authorKononen, Jen_US
dc.contributor.authorWalker, RLen_US
dc.contributor.authorAzorsa, DOen_US
dc.contributor.authorTanner, MMen_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorSauter, Gen_US
dc.contributor.authorKallioniemi, OPen_US
dc.contributor.authorTrent, JMen_US
dc.contributor.authorMeltzer, PSen_US
dc.date.accessioned2012-06-26T06:09:18Z-
dc.date.available2012-06-26T06:09:18Z-
dc.date.issued1997en_US
dc.identifier.citationScience, 1997, v. 277 n. 5328, p. 965-968en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/150728-
dc.description.abstractMembers of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand- dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen- dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBreast - Metabolismen_US
dc.subject.meshBreast Neoplasms - Genetics - Metabolismen_US
dc.subject.meshChromosomes, Human, Pair 20en_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshEstradiol - Metabolism - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshGene Dosageen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshHistone Acetyltransferasesen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshLigandsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNeoplasms, Hormone-Dependent - Genetics - Metabolismen_US
dc.subject.meshNuclear Receptor Coactivator 1en_US
dc.subject.meshNuclear Receptor Coactivator 2en_US
dc.subject.meshOvarian Neoplasms - Genetics - Metabolismen_US
dc.subject.meshReceptors, Estrogen - Genetics - Metabolismen_US
dc.subject.meshTranscription Factors - Geneticsen_US
dc.subject.meshTranscriptional Activationen_US
dc.subject.meshTransfectionen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleAIB1, a steroid receptor coactivator amplified in breast and ovarian canceren_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.277.5328.965en_US
dc.identifier.pmid9252329en_US
dc.identifier.scopuseid_2-s2.0-0030797902en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030797902&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume277en_US
dc.identifier.issue5328en_US
dc.identifier.spage965en_US
dc.identifier.epage968en_US
dc.identifier.isiWOS:A1997XQ98500044-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAnzick, SL=6603376140en_US
dc.identifier.scopusauthoridKononen, J=7003792216en_US
dc.identifier.scopusauthoridWalker, RL=7404928692en_US
dc.identifier.scopusauthoridAzorsa, DO=6601989499en_US
dc.identifier.scopusauthoridTanner, MM=7202127762en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridSauter, G=22945651300en_US
dc.identifier.scopusauthoridKallioniemi, OP=7005031465en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US
dc.identifier.scopusauthoridMeltzer, PS=7102464641en_US

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