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Article: p53 mutations detected in colorectal carcinoma patients in Hong Kong

Titlep53 mutations detected in colorectal carcinoma patients in Hong Kong
Authors
Issue Date1997
Citation
Cancer Epidemiology Biomarkers And Prevention, 1997, v. 6 n. 11, p. 925-930 How to Cite?
AbstractA mutational spectrum for exons 5-8 of the p53 tumor suppressor gene in colorectal carcinomas in Hong Kong Chinese was established. Ninety-nine colorectal carcinomas from Hong Kong patients were analyzed for mutations in p53 gene by PCR-single-strand conformation polymorphism analysis and direct DNA sequencing. Thirty-five of the 99 tumors (35.4%) contained mutations. Point mutations accounted for 80% of all genetic changes and were predominantly base transitions at CpG dinucleotide sites, mutations that were also predominant in Caucasian carcinomas. The major hot spots at codons 175 and 248 of p53 in Caucasians are also hot spots in the Chinese gene. Identical mutations in codons 152 and 306 were detected in two independent tumors in the Chinese, which were reported only rarely in Caucasians. Moreover, a significantly higher frequency (20%) of deletion and insertion mutations was observed in Hong Kong colorectal cancer patients. Distinct genetic and/or environmental factors may contribute to these findings.
Persistent Identifierhttp://hdl.handle.net/10722/150727
ISSN
2015 Impact Factor: 3.622
2015 SCImago Journal Rankings: 2.579
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, CSen_US
dc.contributor.authorCheung, MHYen_US
dc.contributor.authorWong, CMen_US
dc.contributor.authorLau, KWen_US
dc.contributor.authorTang, CMCen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:09:18Z-
dc.date.available2012-06-26T06:09:18Z-
dc.date.issued1997en_US
dc.identifier.citationCancer Epidemiology Biomarkers And Prevention, 1997, v. 6 n. 11, p. 925-930en_US
dc.identifier.issn1055-9965en_US
dc.identifier.urihttp://hdl.handle.net/10722/150727-
dc.description.abstractA mutational spectrum for exons 5-8 of the p53 tumor suppressor gene in colorectal carcinomas in Hong Kong Chinese was established. Ninety-nine colorectal carcinomas from Hong Kong patients were analyzed for mutations in p53 gene by PCR-single-strand conformation polymorphism analysis and direct DNA sequencing. Thirty-five of the 99 tumors (35.4%) contained mutations. Point mutations accounted for 80% of all genetic changes and were predominantly base transitions at CpG dinucleotide sites, mutations that were also predominant in Caucasian carcinomas. The major hot spots at codons 175 and 248 of p53 in Caucasians are also hot spots in the Chinese gene. Identical mutations in codons 152 and 306 were detected in two independent tumors in the Chinese, which were reported only rarely in Caucasians. Moreover, a significantly higher frequency (20%) of deletion and insertion mutations was observed in Hong Kong colorectal cancer patients. Distinct genetic and/or environmental factors may contribute to these findings.en_US
dc.languageengen_US
dc.relation.ispartofCancer Epidemiology Biomarkers and Preventionen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshColorectal Neoplasms - Epidemiology - Geneticsen_US
dc.subject.meshCpg Islandsen_US
dc.subject.meshDna, Neoplasm - Isolation & Purificationen_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshExonsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, P53 - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.titlep53 mutations detected in colorectal carcinoma patients in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9367066-
dc.identifier.scopuseid_2-s2.0-0030775965en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030775965&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue11en_US
dc.identifier.spage925en_US
dc.identifier.epage930en_US
dc.identifier.isiWOS:000071918400009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, CS=7402612613en_US
dc.identifier.scopusauthoridCheung, MHY=37044558100en_US
dc.identifier.scopusauthoridWong, CM=36631385400en_US
dc.identifier.scopusauthoridLau, KW=35080643000en_US
dc.identifier.scopusauthoridTang, CMC=8274797200en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US

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