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Article: Nuclear architecture and the induction of chromosomal aberrations

TitleNuclear architecture and the induction of chromosomal aberrations
Authors
Issue Date1996
Citation
Mutation Research - Reviews In Genetic Toxicology, 1996, v. 366 n. 2, p. 97-116 How to Cite?
AbstractProgress in fluorescence in situ hybridization, three dimensional microscopy and image analysis has provided the means to study the three-dimensional structure and distribution of chromosome territories within the cell nucleus. In this contribution, we summarize the present state of knowledge of the territorial organization of interphase chromosomes and their topological relationships with other macromolecular domains in the human cell nucleus, and present data from computer simulations of chromosome territory distributions. On this basis, we discuss models of chromosome territory and nuclear architecture and topological consequences for the formation of chromosome exchanges. 'The idea of the nucleus as a bag of broken chromosome ends flapping around seeking new partners...seems no longer to be tenable from our picture of the interphase nucleus' (J.R.K. Savage, 1990).
Persistent Identifierhttp://hdl.handle.net/10722/150725
ISSN
1999 SCImago Journal Rankings: 1.619
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCremer, Cen_US
dc.contributor.authorMünkel, Chen_US
dc.contributor.authorGranzow, Men_US
dc.contributor.authorJauch, Aen_US
dc.contributor.authorDietzel, Sen_US
dc.contributor.authorEils, Ren_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorMeltzer, PSen_US
dc.contributor.authorTrent, JMen_US
dc.contributor.authorLangowski, Jen_US
dc.contributor.authorCremer, Ten_US
dc.date.accessioned2012-06-26T06:09:15Z-
dc.date.available2012-06-26T06:09:15Z-
dc.date.issued1996en_US
dc.identifier.citationMutation Research - Reviews In Genetic Toxicology, 1996, v. 366 n. 2, p. 97-116en_US
dc.identifier.issn0165-1110en_US
dc.identifier.urihttp://hdl.handle.net/10722/150725-
dc.description.abstractProgress in fluorescence in situ hybridization, three dimensional microscopy and image analysis has provided the means to study the three-dimensional structure and distribution of chromosome territories within the cell nucleus. In this contribution, we summarize the present state of knowledge of the territorial organization of interphase chromosomes and their topological relationships with other macromolecular domains in the human cell nucleus, and present data from computer simulations of chromosome territory distributions. On this basis, we discuss models of chromosome territory and nuclear architecture and topological consequences for the formation of chromosome exchanges. 'The idea of the nucleus as a bag of broken chromosome ends flapping around seeking new partners...seems no longer to be tenable from our picture of the interphase nucleus' (J.R.K. Savage, 1990).en_US
dc.languageengen_US
dc.relation.ispartofMutation Research - Reviews in Genetic Toxicologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Nucleus - Genetics - Radiation Effects - Ultrastructureen_US
dc.subject.meshChromosome Aberrations - Geneticsen_US
dc.subject.meshChromosomes - Genetics - Radiation Effects - Ultrastructureen_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Anatomicen_US
dc.subject.meshModels, Geneticen_US
dc.titleNuclear architecture and the induction of chromosomal aberrationsen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-1110(96)90031-7en_US
dc.identifier.pmid9001577-
dc.identifier.scopuseid_2-s2.0-0030292824en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030292824&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume366en_US
dc.identifier.issue2en_US
dc.identifier.spage97en_US
dc.identifier.epage116en_US
dc.identifier.isiWOS:A1996VZ22400004-
dc.identifier.scopusauthoridCremer, C=7006932808en_US
dc.identifier.scopusauthoridMünkel, Ch=22963240800en_US
dc.identifier.scopusauthoridGranzow, M=6603113998en_US
dc.identifier.scopusauthoridJauch, A=7004786567en_US
dc.identifier.scopusauthoridDietzel, S=6602169020en_US
dc.identifier.scopusauthoridEils, R=7003976942en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridMeltzer, PS=7102464641en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US
dc.identifier.scopusauthoridLangowski, J=7005737357en_US
dc.identifier.scopusauthoridCremer, T=7005758215en_US

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