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Article: Chromosome microdissection identifies cryptic sites of DNA sequence amplification in human ovarian carcinoma

TitleChromosome microdissection identifies cryptic sites of DNA sequence amplification in human ovarian carcinoma
Authors
Issue Date1995
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1995, v. 55 n. 15, p. 3380-3385 How to Cite?
AbstractDNA sequence amplification contributes to the multistep process of carcinogenesis, and overexpression of amplified genes has been shown to contribute tn the malignant phenotype. Cytogenetic analyses of human tumor cells, including ovarian malignancies, frequently show cytological evidence of DNA amplification in the form of double minutes and homogeneously staining regions. In this report, we have combined the techniques of chromosome microdissection and fluorescence in situ hybridization (P. S. Meltzer et al., Nat. Genet., 1: 24-28, 1992) to identify the composition and chromosomal origin of seven homogeneously staining regions from seven eases of ovarian cancer. Twelve specific chromosome band regions were identified as amplified including 11q, 12p, 16p, 19p, and 19q. These results provide important insights into the organization of amplified sequences within ovarian malignancies and add further to our recognition of regions likely to harbor genes important to the development or progression of ovarian cancer.
Persistent Identifierhttp://hdl.handle.net/10722/150717
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGuan, XYen_US
dc.contributor.authorCargile, CBen_US
dc.contributor.authorAnzick, SLen_US
dc.contributor.authorThompson, FHen_US
dc.contributor.authorMeltzer, PSen_US
dc.contributor.authorBittner, MLen_US
dc.contributor.authorTaetle, Ren_US
dc.contributor.authorMcgill, JRen_US
dc.contributor.authorTrent, JMen_US
dc.date.accessioned2012-06-26T06:09:09Z-
dc.date.available2012-06-26T06:09:09Z-
dc.date.issued1995en_US
dc.identifier.citationCancer Research, 1995, v. 55 n. 15, p. 3380-3385en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/150717-
dc.description.abstractDNA sequence amplification contributes to the multistep process of carcinogenesis, and overexpression of amplified genes has been shown to contribute tn the malignant phenotype. Cytogenetic analyses of human tumor cells, including ovarian malignancies, frequently show cytological evidence of DNA amplification in the form of double minutes and homogeneously staining regions. In this report, we have combined the techniques of chromosome microdissection and fluorescence in situ hybridization (P. S. Meltzer et al., Nat. Genet., 1: 24-28, 1992) to identify the composition and chromosomal origin of seven homogeneously staining regions from seven eases of ovarian cancer. Twelve specific chromosome band regions were identified as amplified including 11q, 12p, 16p, 19p, and 19q. These results provide important insights into the organization of amplified sequences within ovarian malignancies and add further to our recognition of regions likely to harbor genes important to the development or progression of ovarian cancer.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshAgeden_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNucleic Acid Amplification Techniquesen_US
dc.subject.meshOvarian Neoplasms - Geneticsen_US
dc.titleChromosome microdissection identifies cryptic sites of DNA sequence amplification in human ovarian carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7614475-
dc.identifier.scopuseid_2-s2.0-0029154507en_US
dc.identifier.volume55en_US
dc.identifier.issue15en_US
dc.identifier.spage3380en_US
dc.identifier.epage3385en_US
dc.identifier.isiWOS:A1995RL49300027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridCargile, CB=6603210591en_US
dc.identifier.scopusauthoridAnzick, SL=6603376140en_US
dc.identifier.scopusauthoridThompson, FH=7202217465en_US
dc.identifier.scopusauthoridMeltzer, PS=7102464641en_US
dc.identifier.scopusauthoridBittner, ML=35371357800en_US
dc.identifier.scopusauthoridTaetle, R=7006711648en_US
dc.identifier.scopusauthoridMcGill, JR=7101993026en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US

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