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Article: Gene amplification elucidated by combined chromosomal microdissection and comparative genomic hybridization

TitleGene amplification elucidated by combined chromosomal microdissection and comparative genomic hybridization
Authors
Issue Date1995
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1995, v. 80 n. 1, p. 55-59 How to Cite?
AbstractGene amplification is an important manifestation of genetic instability in cancer. Recently, the study of gene amplification has been greatly facilitated by the development of the molecular cytogenetic techniques of comparative genomic hybridization and chromosome microdissection. We describe in this brief overview a combined approach using both techniques, which allows the identification of chromosomal regions of gone amplification and provides entry point clones for target gene identification. This molecular/cytogenetic approach consisting of chromosome microdissection and comparative genomic hybridization should be valuable in identifying novel amplified genes important in neoplastic development and progression.
Persistent Identifierhttp://hdl.handle.net/10722/150714
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiang, BCen_US
dc.contributor.authorMeltzer, PSen_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorTrent, JMen_US
dc.date.accessioned2012-06-26T06:09:07Z-
dc.date.available2012-06-26T06:09:07Z-
dc.date.issued1995en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1995, v. 80 n. 1, p. 55-59en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/150714-
dc.description.abstractGene amplification is an important manifestation of genetic instability in cancer. Recently, the study of gene amplification has been greatly facilitated by the development of the molecular cytogenetic techniques of comparative genomic hybridization and chromosome microdissection. We describe in this brief overview a combined approach using both techniques, which allows the identification of chromosomal regions of gone amplification and provides entry point clones for target gene identification. This molecular/cytogenetic approach consisting of chromosome microdissection and comparative genomic hybridization should be valuable in identifying novel amplified genes important in neoplastic development and progression.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshChromosomesen_US
dc.subject.meshDna, Neoplasmen_US
dc.subject.meshDissection - Methodsen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshIn Situ Hybridization, Fluorescence - Methodsen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.titleGene amplification elucidated by combined chromosomal microdissection and comparative genomic hybridizationen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0165-4608(94)00153-3en_US
dc.identifier.pmid7697633-
dc.identifier.scopuseid_2-s2.0-0028904998en_US
dc.identifier.volume80en_US
dc.identifier.issue1en_US
dc.identifier.spage55en_US
dc.identifier.epage59en_US
dc.identifier.isiWOS:A1995QQ23000011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiang, BC=7202071001en_US
dc.identifier.scopusauthoridMeltzer, PS=7102464641en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US

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