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Article: Genotypic analysis of Epstein-Barr virus isolates associated with nasopharyngeal carcinoma in Chinese immigrants to the United States

TitleGenotypic analysis of Epstein-Barr virus isolates associated with nasopharyngeal carcinoma in Chinese immigrants to the United States
Authors
Issue Date1994
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1994, v. 59 n. 6, p. 743-746 How to Cite?
AbstractEBV genotypes of first- and second-generation Chinese diagnosed with nasopharyngeal carcinoma in the United States were analyzed by PCR techniques. Previous studies showed a geographical distribution of genotypically distinct sub-types of EBV. Viruses detected at a higher frequency among Chinese NPC patients (Cf) were distinguished from those found in the majority of Caucasian NPC patients (Up) in the United States by polymorphisms in the BamHI F and I regions. Exploiting this distinction, we analyzed the biopsies of Chinese immigrants in the United States far their C/D and F/f genotypes to evaluate the importance of retention of the Cf virus among Chinese NPC patients in a geographical area where the DF virus prevails. This study shows that approximately 45.5 to 50% of first- and second-generation Chinese NPC patients in California harbor the Cf virus, which is present in only 8% of Caucasian NPC patients in California. It is interesting that, while only 48% of the viral isolates from immigrant Chinese to California harbor the 'f' variant, 96% harbor the type-C viruses.
Persistent Identifierhttp://hdl.handle.net/10722/150712
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_US
dc.contributor.authorChang, GCen_US
dc.contributor.authorMiller, TRen_US
dc.contributor.authorWara, WMen_US
dc.contributor.authorPhillips, TLen_US
dc.date.accessioned2012-06-26T06:09:06Z-
dc.date.available2012-06-26T06:09:06Z-
dc.date.issued1994en_US
dc.identifier.citationInternational Journal Of Cancer, 1994, v. 59 n. 6, p. 743-746en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://hdl.handle.net/10722/150712-
dc.description.abstractEBV genotypes of first- and second-generation Chinese diagnosed with nasopharyngeal carcinoma in the United States were analyzed by PCR techniques. Previous studies showed a geographical distribution of genotypically distinct sub-types of EBV. Viruses detected at a higher frequency among Chinese NPC patients (Cf) were distinguished from those found in the majority of Caucasian NPC patients (Up) in the United States by polymorphisms in the BamHI F and I regions. Exploiting this distinction, we analyzed the biopsies of Chinese immigrants in the United States far their C/D and F/f genotypes to evaluate the importance of retention of the Cf virus among Chinese NPC patients in a geographical area where the DF virus prevails. This study shows that approximately 45.5 to 50% of first- and second-generation Chinese NPC patients in California harbor the Cf virus, which is present in only 8% of Caucasian NPC patients in California. It is interesting that, while only 48% of the viral isolates from immigrant Chinese to California harbor the 'f' variant, 96% harbor the type-C viruses.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_US
dc.relation.ispartofInternational Journal of Canceren_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCaliforniaen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshEmigration And Immigrationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHerpesvirus 4, Human - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNasopharyngeal Neoplasms - Ethnology - Virologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshSensitivity And Specificityen_US
dc.titleGenotypic analysis of Epstein-Barr virus isolates associated with nasopharyngeal carcinoma in Chinese immigrants to the United Statesen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ijc.2910590605en_US
dc.identifier.pmid7989111-
dc.identifier.scopuseid_2-s2.0-0028590131en_US
dc.identifier.volume59en_US
dc.identifier.issue6en_US
dc.identifier.spage743en_US
dc.identifier.epage746en_US
dc.identifier.isiWOS:A1994QF91600004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.scopusauthoridChang, GC=7402309089en_US
dc.identifier.scopusauthoridMiller, TR=16171679900en_US
dc.identifier.scopusauthoridWara, WM=24502142300en_US
dc.identifier.scopusauthoridPhillips, TL=7401766706en_US

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