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- Publisher Website: 10.1002/ijc.2910590605
- Scopus: eid_2-s2.0-0028590131
- PMID: 7989111
- WOS: WOS:A1994QF91600004
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Article: Genotypic analysis of Epstein-Barr virus isolates associated with nasopharyngeal carcinoma in Chinese immigrants to the United States
Title | Genotypic analysis of Epstein-Barr virus isolates associated with nasopharyngeal carcinoma in Chinese immigrants to the United States |
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Authors | |
Issue Date | 1994 |
Publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home |
Citation | International Journal Of Cancer, 1994, v. 59 n. 6, p. 743-746 How to Cite? |
Abstract | EBV genotypes of first- and second-generation Chinese diagnosed with nasopharyngeal carcinoma in the United States were analyzed by PCR techniques. Previous studies showed a geographical distribution of genotypically distinct sub-types of EBV. Viruses detected at a higher frequency among Chinese NPC patients (Cf) were distinguished from those found in the majority of Caucasian NPC patients (Up) in the United States by polymorphisms in the BamHI F and I regions. Exploiting this distinction, we analyzed the biopsies of Chinese immigrants in the United States far their C/D and F/f genotypes to evaluate the importance of retention of the Cf virus among Chinese NPC patients in a geographical area where the DF virus prevails. This study shows that approximately 45.5 to 50% of first- and second-generation Chinese NPC patients in California harbor the Cf virus, which is present in only 8% of Caucasian NPC patients in California. It is interesting that, while only 48% of the viral isolates from immigrant Chinese to California harbor the 'f' variant, 96% harbor the type-C viruses. |
Persistent Identifier | http://hdl.handle.net/10722/150712 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 2.131 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lung, ML | en_US |
dc.contributor.author | Chang, GC | en_US |
dc.contributor.author | Miller, TR | en_US |
dc.contributor.author | Wara, WM | en_US |
dc.contributor.author | Phillips, TL | en_US |
dc.date.accessioned | 2012-06-26T06:09:06Z | - |
dc.date.available | 2012-06-26T06:09:06Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | International Journal Of Cancer, 1994, v. 59 n. 6, p. 743-746 | en_US |
dc.identifier.issn | 0020-7136 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/150712 | - |
dc.description.abstract | EBV genotypes of first- and second-generation Chinese diagnosed with nasopharyngeal carcinoma in the United States were analyzed by PCR techniques. Previous studies showed a geographical distribution of genotypically distinct sub-types of EBV. Viruses detected at a higher frequency among Chinese NPC patients (Cf) were distinguished from those found in the majority of Caucasian NPC patients (Up) in the United States by polymorphisms in the BamHI F and I regions. Exploiting this distinction, we analyzed the biopsies of Chinese immigrants in the United States far their C/D and F/f genotypes to evaluate the importance of retention of the Cf virus among Chinese NPC patients in a geographical area where the DF virus prevails. This study shows that approximately 45.5 to 50% of first- and second-generation Chinese NPC patients in California harbor the Cf virus, which is present in only 8% of Caucasian NPC patients in California. It is interesting that, while only 48% of the viral isolates from immigrant Chinese to California harbor the 'f' variant, 96% harbor the type-C viruses. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home | en_US |
dc.relation.ispartof | International Journal of Cancer | en_US |
dc.subject.mesh | Base Sequence | en_US |
dc.subject.mesh | California | en_US |
dc.subject.mesh | China - Ethnology | en_US |
dc.subject.mesh | Emigration And Immigration | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Herpesvirus 4, Human - Genetics | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Nasopharyngeal Neoplasms - Ethnology - Virology | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Sensitivity And Specificity | en_US |
dc.title | Genotypic analysis of Epstein-Barr virus isolates associated with nasopharyngeal carcinoma in Chinese immigrants to the United States | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lung, ML:mlilung@hku.hk | en_US |
dc.identifier.authority | Lung, ML=rp00300 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/ijc.2910590605 | en_US |
dc.identifier.pmid | 7989111 | - |
dc.identifier.scopus | eid_2-s2.0-0028590131 | en_US |
dc.identifier.volume | 59 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 743 | en_US |
dc.identifier.epage | 746 | en_US |
dc.identifier.isi | WOS:A1994QF91600004 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lung, ML=7006411788 | en_US |
dc.identifier.scopusauthorid | Chang, GC=7402309089 | en_US |
dc.identifier.scopusauthorid | Miller, TR=16171679900 | en_US |
dc.identifier.scopusauthorid | Wara, WM=24502142300 | en_US |
dc.identifier.scopusauthorid | Phillips, TL=7401766706 | en_US |
dc.identifier.issnl | 0020-7136 | - |