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Article: Clonal chromosome abnormalities in 54 cases of ovarian carcinoma

TitleClonal chromosome abnormalities in 54 cases of ovarian carcinoma
Authors
Issue Date1994
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1994, v. 73 n. 1, p. 33-45 How to Cite?
AbstractAs a prelude to assessing the relationship of chromosome alterations to clinical outcome in ovarian carcinoma, we report on the cytogenetic analysis on short-term cultures from 54 patients. All patients had histopathologically confirmed malignancy, with the majority of cases demonstrating serous ovarian adenocarcinomas. Structural alterations were evident in 52 cases, whereas numeric changes were identified in 13 cases. The most notable numeric abnormalities were loss of the X-chromosome (9/13 total cases) and +7 (3/9 diploid cases). Structural alterations most frequently involved chromosomes 1, 3, 6, 7, 11, and 12. Chromosomal breakpoints were shown to cluster in several chromosomal banding regions, including 1p36, 1p11-q21, 3p23-p10, 7p (especially 7p22), 11p, 11q, 12p13-q12, and 12q24. The frequency of structural alterations involving the following chromosome arms was found to be significantly increased: 1p (p < 0.01), 7p (p < 0.01), 11p (p < 0.01), 11q (p < 0.05), and 12p (p < 0.05). An analysis of the net gain or loss of chromosome segments was also performed, with the most consistent tendency observed being over-representation of 1q and chromosome 7, deletion of 1p, and loss of the X chromosome.
Persistent Identifierhttp://hdl.handle.net/10722/150710
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorThompson, FHen_US
dc.contributor.authorEmerson, Jen_US
dc.contributor.authorAlberts, Den_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorBurgess, Aen_US
dc.contributor.authorFox, Sen_US
dc.contributor.authorTaetle, Ren_US
dc.contributor.authorWeinstein, Ren_US
dc.contributor.authorMakar, Ren_US
dc.contributor.authorPowell, Den_US
dc.contributor.authorTrent, Jen_US
dc.date.accessioned2012-06-26T06:09:05Z-
dc.date.available2012-06-26T06:09:05Z-
dc.date.issued1994en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1994, v. 73 n. 1, p. 33-45en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/150710-
dc.description.abstractAs a prelude to assessing the relationship of chromosome alterations to clinical outcome in ovarian carcinoma, we report on the cytogenetic analysis on short-term cultures from 54 patients. All patients had histopathologically confirmed malignancy, with the majority of cases demonstrating serous ovarian adenocarcinomas. Structural alterations were evident in 52 cases, whereas numeric changes were identified in 13 cases. The most notable numeric abnormalities were loss of the X-chromosome (9/13 total cases) and +7 (3/9 diploid cases). Structural alterations most frequently involved chromosomes 1, 3, 6, 7, 11, and 12. Chromosomal breakpoints were shown to cluster in several chromosomal banding regions, including 1p36, 1p11-q21, 3p23-p10, 7p (especially 7p22), 11p, 11q, 12p13-q12, and 12q24. The frequency of structural alterations involving the following chromosome arms was found to be significantly increased: 1p (p < 0.01), 7p (p < 0.01), 11p (p < 0.01), 11q (p < 0.05), and 12p (p < 0.05). An analysis of the net gain or loss of chromosome segments was also performed, with the most consistent tendency observed being over-representation of 1q and chromosome 7, deletion of 1p, and loss of the X chromosome.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosome Bandingen_US
dc.subject.meshCystadenocarcinoma, Serous - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOvarian Neoplasms - Geneticsen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleClonal chromosome abnormalities in 54 cases of ovarian carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0165-4608(94)90179-1en_US
dc.identifier.pmid8174072-
dc.identifier.scopuseid_2-s2.0-0028282920en_US
dc.identifier.volume73en_US
dc.identifier.issue1en_US
dc.identifier.spage33en_US
dc.identifier.epage45en_US
dc.identifier.isiWOS:A1994NQ88600006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridThompson, FH=7202217465en_US
dc.identifier.scopusauthoridEmerson, J=35919442400en_US
dc.identifier.scopusauthoridAlberts, D=35380854000en_US
dc.identifier.scopusauthoridLiu, Y=36071856600en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridBurgess, A=7201495330en_US
dc.identifier.scopusauthoridFox, S=7401924543en_US
dc.identifier.scopusauthoridTaetle, R=7006711648en_US
dc.identifier.scopusauthoridWeinstein, R=7202286020en_US
dc.identifier.scopusauthoridMakar, R=7004336157en_US
dc.identifier.scopusauthoridPowell, D=7402430467en_US
dc.identifier.scopusauthoridTrent, J=7201692482en_US

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