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Article: Identification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection

TitleIdentification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection
Authors
Issue Date1994
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 1994, v. 8 n. 2, p. 155-161 How to Cite?
AbstractWe have performed microdissection of 16 putative homogeneously staining regions (hsrs) from nine different breast cancer cell lines in order to determine their chromosomal origin and composition. As expected, the most commonly amplified chromosomal band-region was 17q12 (containing ERBB2). However, regions not containing known oncogenes were also identified, including 13q31 (5/9 cases) and 20q12-13.2 (4/9 cases). The chromosomal composition of the integrated amplified DNA within each hsr was determined and in 13/16 cases (81%), hsrs were shown to be composed of two or more chromosomal regions. These studies shed light on the mechanism of formation of hsrs, and identify chromosomal regions likely to harbour genes amplified in breast cancer.
Persistent Identifierhttp://hdl.handle.net/10722/150705
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGuan, XYen_US
dc.contributor.authorMeltzer, PSen_US
dc.contributor.authorDalton, WSen_US
dc.contributor.authorTrent, JMen_US
dc.date.accessioned2012-06-26T06:09:01Z-
dc.date.available2012-06-26T06:09:01Z-
dc.date.issued1994en_US
dc.identifier.citationNature Genetics, 1994, v. 8 n. 2, p. 155-161en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/150705-
dc.description.abstractWe have performed microdissection of 16 putative homogeneously staining regions (hsrs) from nine different breast cancer cell lines in order to determine their chromosomal origin and composition. As expected, the most commonly amplified chromosomal band-region was 17q12 (containing ERBB2). However, regions not containing known oncogenes were also identified, including 13q31 (5/9 cases) and 20q12-13.2 (4/9 cases). The chromosomal composition of the integrated amplified DNA within each hsr was determined and in 13/16 cases (81%), hsrs were shown to be composed of two or more chromosomal regions. These studies shed light on the mechanism of formation of hsrs, and identify chromosomal regions likely to harbour genes amplified in breast cancer.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_US
dc.relation.ispartofNature Geneticsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBreast Neoplasms - Geneticsen_US
dc.subject.meshChromosome Bandingen_US
dc.subject.meshChromosomes, Human - Ultrastructureen_US
dc.subject.meshChromosomes, Human, Pair 13 - Ultrastructureen_US
dc.subject.meshChromosomes, Human, Pair 17 - Ultrastructureen_US
dc.subject.meshChromosomes, Human, Pair 20 - Ultrastructureen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescence - Methodsen_US
dc.subject.meshMicromanipulationen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshOncogenesen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleIdentification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissectionen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ng1094-155en_US
dc.identifier.pmid7842014-
dc.identifier.scopuseid_2-s2.0-0028001095en_US
dc.identifier.volume8en_US
dc.identifier.issue2en_US
dc.identifier.spage155en_US
dc.identifier.epage161en_US
dc.identifier.isiWOS:A1994PL12300017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridMeltzer, PS=7102464641en_US
dc.identifier.scopusauthoridDalton, WS=35379799400en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US

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