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Article: Analysis of Epstein-Barr virus in localized nasopharyngeal carcinoma tumors

TitleAnalysis of Epstein-Barr virus in localized nasopharyngeal carcinoma tumors
Authors
Issue Date1993
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1993, v. 71 n. 4, p. 1190-1192 How to Cite?
AbstractBackground. An f variant of Epstein-Barr virus (EBV) appears associated with nasopharyngeal carcinoma (NPC) in Southern Chinese. Early diagnosis of the tumor allows the detection of some localized tumors. Methods. A polymerase chain reaction (PCR) assay for genotyping EBV was used to evaluate the presence of the virus in NPC biopsies of local tumors of eight Chinese patients. Results. The f variant was detected in the nasopharynx of seven of eight patients. The f variant was present in equal frequency in the 'normal' and tumor regions. Conclusions. Examination of localized NPC tumors by the PCR genotyping assay revealed EBV was present on the tumor side of the nasopharynx in greater quantities than the 'normal' side in seven of eight patients studied. Concurrent infection with both the prototype F and f variant was observed in two of the eight patients investigated.
Persistent Identifierhttp://hdl.handle.net/10722/150703
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorWai Pang Lamen_US
dc.contributor.authorChoy, DTKen_US
dc.date.accessioned2012-06-26T06:09:00Z-
dc.date.available2012-06-26T06:09:00Z-
dc.date.issued1993en_US
dc.identifier.citationCancer, 1993, v. 71 n. 4, p. 1190-1192en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/150703-
dc.description.abstractBackground. An f variant of Epstein-Barr virus (EBV) appears associated with nasopharyngeal carcinoma (NPC) in Southern Chinese. Early diagnosis of the tumor allows the detection of some localized tumors. Methods. A polymerase chain reaction (PCR) assay for genotyping EBV was used to evaluate the presence of the virus in NPC biopsies of local tumors of eight Chinese patients. Results. The f variant was detected in the nasopharynx of seven of eight patients. The f variant was present in equal frequency in the 'normal' and tumor regions. Conclusions. Examination of localized NPC tumors by the PCR genotyping assay revealed EBV was present on the tumor side of the nasopharynx in greater quantities than the 'normal' side in seven of eight patients studied. Concurrent infection with both the prototype F and f variant was observed in two of the eight patients investigated.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.subject.meshCarcinoma - Microbiologyen_US
dc.subject.meshDna, Viral - Geneticsen_US
dc.subject.meshDna-Cytosine Methylasesen_US
dc.subject.meshGene Amplificationen_US
dc.subject.meshGenes, Ras - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHerpesvirus 4, Human - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshNasopharyngeal Neoplasms - Microbiologyen_US
dc.subject.meshNasopharynx - Microbiologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshTumor Virus Infectionsen_US
dc.titleAnalysis of Epstein-Barr virus in localized nasopharyngeal carcinoma tumorsen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0142(19930215)71:4<1190::AID-CNCR2820710403>3.0.CO;2-Ben_US
dc.identifier.pmid8382103-
dc.identifier.scopuseid_2-s2.0-0027525871en_US
dc.identifier.volume71en_US
dc.identifier.issue4en_US
dc.identifier.spage1190en_US
dc.identifier.epage1192en_US
dc.identifier.isiWOS:A1993KN06400002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.scopusauthoridSham, JST=8967933200en_US
dc.identifier.scopusauthoridWai Pang Lam=16141397200en_US
dc.identifier.scopusauthoridChoy, DTK=7102939127en_US

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